甘肃省科技创新体系建设及成就

改革开放以来,甘肃省持续增加科技投入,不断加强科技创新体系建设,提升自主创新能力,全省科技实力显著增强。对甘肃省在科技创新成果、创新能力、创新人才、专利保护等方面取得的辉煌成绩进行了简要概述。     

带有临界位势的超线性椭圆方程Dirichlet问题的无穷多解

在比（AR）条件更弱的一类超线性条件之下,利用变分方法讨论了一类带有临界位势的超线性椭圆方程Dirichlet问题的无穷多解的存在性。     

Developing anti-neoplastic biotherapeutics against eIF4F

Biotherapeutics have revolutionized modern medicine by providing medicines that would not have been possible with small molecules. With respect to cancer therapies, this represents the current sector of the pharmaceutical industry having the largest therapeutic impact, as exemplified by the development of recombinant antibodies and cell-based therapies. In cancer, one of the most common regulatory alterations is the perturbation of translational control. Among these, changes in eukaryotic initiation factor 4F (eIF4F) are associated with tumor initiation, progression, and drug resistance in a number of settings. This, coupled with the fact that systemic suppression of eIF4F appears well tolerated, indicates that therapeutic agents targeting eIF4F hold much therapeutic potential. Here, we discuss opportunities offered by biologicals for this purpose.     

Euler’s beta integral in Pietro Mengoli’s works

Beta integrals for several non-integer values of the exponents were calculated by Leonhard Euler in 1730, when he was trying to find the general term for the factorial function by means of an algebraic expression. Nevertheless, 70 years before, Pietro Mengoli (1626–1686) had computed such integrals for natural and half-integer exponents in his Geometriae Speciosae Elementa (1659) and Circolo(1672) and displayed the results in triangular tables. In particular, his new arithmetic–algebraic method allowed him to compute the quadrature of the circle. The aim of this article is to show how Mengoli calculated the values of these integrals as well as how he analysed the relation between these values and the exponents inside the integrals. This analysis provides new insights into Mengoli’s view of his algorithmic computation of quadratures.     

不同冲击间隔分布下经典δ冲击模型的参数估计1

通过极大似然估计方法,对冲击时间间隔服从[0, b]上均匀分布、参数为λ的指数分布以及一般更新过程的经典δ冲击模型的参数δ、λ和b进行估计,得到了其相应的估计量。     

Deep cleaning of a metallurgical zinc leaching residue and recovery of valuable metals

Huge quantities of zinc leaching residues (ZLRs) generated from zinc production are dumped continuously around the world and pose a potential environmental threat because of their considerable amounts of entrained heavy metals (mainly lead). Most ZLRs have not been properly treated and the valuable metals in them have not yet been effectively recovered. Herein, the deep cleaning of a ZLR and recovery of valuable metals via a hydrometallurgical route were investigated. The cleaning process consists of two essential stages:acid leaching followed by calcium chloride leaching. The optimum conditions for extracting zinc, copper, and indium by acid leaching were a sulfuric acid concentration of 200 g·L-1, a liquid/solid ratio of 4:1 (mL/g), a leaching time of 2 h, and a temperature of 90℃. For lead and silver extractions, the optimum conditions were a calcium chloride concentration of 400 g·L-1, a pH value of 1.0, a leaching time of 1 h, and a temperature of 30℃. After calcium chloride leaching, silver and lead were extracted out and the lead was finally recovered as electrolytic lead by electrowinning. The anglesite phase, which poses the greatest potential environmental hazard, was removed from the ZLR after deep cleaning, thus reducing the cost of environmental management of ZLRs. The treatment of chlorine and spent electrolyte generated in the process was discussed.     

基于机械式变速器脱挡故障分析与预防

脱挡是汽车变速器的常见故障之一,笔者从机械式变速器脱挡故障现象入手,从整车和变速器两方面对脱挡故障展开分析,并提出了预防解决措施,提升机械式变速器可靠性能。     

概念精准与逻辑严密视角下对"密度"概念教学思路的再认识

"密度"作为初中物理引入最早、抽象程度最高的概念,历来都是教学的重点和难点,针对"密度"在日常教学中存在的症结,联系学生朴素认识,导入密度物理意义;直接比较物体质量,成功引发认知冲突;找出谬误产生根源,合理修正先前假设;结合具体实验数据,尝试诠释比值内涵;巧妙安排问题顺序,完成密度学习进阶4个环节,并对教学效果进行了相关的实证分析,教学效果很好.