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61.
Sayer JA Otto EA O'Toole JF Nurnberg G Kennedy MA Becker C Hennies HC Helou J Attanasio M Fausett BV Utsch B Khanna H Liu Y Drummond I Kawakami I Kusakabe T Tsuda M Ma L Lee H Larson RG Allen SJ Wilkinson CJ Nigg EA Shou C Lillo C Williams DS Hoppe B Kemper MJ Neuhaus T Parisi MA Glass IA Petry M Kispert A Gloy J Ganner A Walz G Zhu X Goldman D Nurnberg P Swaroop A Leroux MR Hildebrandt F 《Nature genetics》2006,38(6):674-681
62.
介绍了实行本科生导师制的必要性,分析了学分制下本科生导师制面临的问题,提出了实施和完善本科生导师制的措施。 相似文献
63.
The present study mainly probed the relationships between ERP components and the degrees of difficulty in visual search. Three experimental and one controlled conditions were randomly selected. Results showed that the P1, N1, and P2 amplitudes and latencies had no significant differences among the three experimental and one controlled conditions, and the ERP waveforms of low perceptual load of visual search were different from that of high perceptual load. These results might indicate that the latencies and amplitudes of initial P1, N1 and P2 in high and low perceptual load conditions were almost the same. The ERP waveforms of parallel search were very different from that of serial search, and the ERP waveforms of serial search were very similar. The P3 amplitudes increased as the degrees of the difficulty in visual search decreased. 相似文献
64.
通过网络、书籍、学术期刊及实地考察等渠道,共搜集了55家海洋主题公园的详细资料进行分析,从中获得了国内海洋主题公园发展的总体概况;对国内海洋主题公园的发展历程进行回顾,归纳并阐述了其不同发展阶段所表现出的主要特征,总结了海洋主题公园发展的生命周期规律及经验教训,以期为已经运营或拟建的海洋主题公园提供借鉴. 相似文献
65.
66.
目前许多高校师生与校领导之间在信息沟通方面存在响应速度慢、办事效率低,甚至师生对学校的许多合理化建议由于缺乏良好的沟通工具而无法及时反映给校领导,给教学管理工作带来了诸多问题,高等学校政务热线系统能有效地帮助领导制定教不管理政策。 相似文献
67.
通过归纳总结作为发达地区的华东部分省市技术创新体系建设的特点和经验 ,为其他省市尤其是欠发达地区的技术创新体系建设工作提供参考借鉴。 相似文献
68.
The conception of flexible constraint is proposed in the paper. The solution of flexible constraint is in special range, and maybe different in different instances of same design scheme. The paper emphasis on how to evaluate and optimize a design scheme with flexible constraints based on the satisfaction degree function defined on flexible constraints. The conception of flexible constraint is used to solve constraint conflict and design optimization in complicated constraint-based assembly design by the PFM parametrization assembly design system. An instance of gear-box design is used for verifying optimization method. 相似文献
69.
Msx2 deficiency in mice causes pleiotropic defects in bone growth and ectodermal organ formation 总被引:20,自引:0,他引:20
Satokata I Ma L Ohshima H Bei M Woo I Nishizawa K Maeda T Takano Y Uchiyama M Heaney S Peters H Tang Z Maxson R Maas R 《Nature genetics》2000,24(4):391-395
The composite structure of the mammalian skull, which forms predominantly via intramembranous ossification, requires precise pre- and post-natal growth regulation of individual calvarial elements. Disturbances of this process frequently cause severe clinical manifestations in humans. Enhanced DNA binding by a mutant MSX2 homeodomain results in a gain of function and produces craniosynostosis in humans. Here we show that Msx2-deficient mice have defects of skull ossification and persistent calvarial foramen. This phenotype results from defective proliferation of osteoprogenitors at the osteogenic front during calvarial morphogenesis, and closely resembles that associated with human MSX2 haploinsufficiency in parietal foramina (PFM). Msx2-/- mice also have defects in endochondral bone formation. In the axial and appendicular skeleton, post-natal deficits in Pth/Pthrp receptor (Pthr) signalling and in expression of marker genes for bone differentiation indicate that Msx2 is required for both chondrogenesis and osteogenesis. Consistent with phenotypes associated with PFM, Msx2-mutant mice also display defective tooth, hair follicle and mammary gland development, and seizures, the latter accompanied by abnormal development of the cerebellum. Most Msx2-mutant phenotypes, including calvarial defects, are enhanced by genetic combination with Msx1 loss of function, indicating that Msx gene dosage can modify expression of the PFM phenotype. Our results provide a developmental basis for PFM and demonstrate that Msx2 is essential at multiple sites during organogenesis. 相似文献
70.