Investigation of hrDNA targeting vector-mediated tumor-specific suicide gene therapy for hepatocellular carcinoma

Vectors pose most pivotal problem of gene therapy[1]. Because of the high transfection efficiency both in vitro and in vivo, the viral vector has been employed in 70% clinical trials of gene therapy (http://www.wiley.co.uk/ genmed/clinical). However, thei…     

Criterions and Measures of Route Selection of Shallowly Embedded Long.Distance Oil and Gas Pipeline in Mountain Areas

According to the engineering investigation of long-distance oil and gas pipelines, the criterions and measures of route selection are drawn as follows： the flat landform is the first choice in route alignment. The foot of mountain is the first choice when the route passes by the valley. The route should pass by but the shady and deposited slope and not in sunny and erosive slope as possible as it can. The pipeline should be vertical to contour climbing and descending the mountain except steep slope. Tunnel can be used in crossing foothill. Perpendicularly traversing the river is better than beveling; the worst choice is to put the pipeline along the river. Bypass is the best choice in karsts area. The order of route selection should be pre-choosing, investigation, optimization and adjustment.     

蓝色圆珠笔油墨的HPLC鉴别

本文采用高效液相色谱法对国内外生产的各种蓝色圆珠笔油墨的种类进行了鉴别。采用ZORBAXBonus-RP柱,流动相为乙腈-水,检测波长为580nm,柱温25℃,本法简便,准确,灵敏度高,重复性好,可用于蓝色圆珠笔油墨种类的鉴定。     

Anti-interference method for HF radars by transmitting phase-modulated chirps

Radio frequency interference （RFI） is a major problem in high-frequency （HF） radars. Conventional filtering-involved RFI suppression methods may introduce distortions to the target signals of interest and often demand extra hardware costs. In this paper, a novel method for RFI suppression by using linearly or randomly phase-modulated （PM） chirps is proposed, which enables independent analyses of the target signal and the RFI. Furthermore, the directions of arrival （DOA） of the interference are used as constraints to ensure a better DOA estimation of the target. The effectiveness of the method is demonstrated by numerical simulation results. The method can greatly improve the anti-interference capabilities of HF radars and is extremely applicable in the portable and low-cost radar systems.     

Load-Balance Policy in Two Level-Cluster File System

In this paper, we explored a load-balancing algorithm in a cluster file system contains two levels of metadata-server, primary-level server quickly distributestasks to second-level servers depending on the closest load-balancing information. At the same time, we explored a method which accurately reflect I/O traffic and storage of storage-node： computing the heat-value of file, according to which we realized a more logical storage allocation. According to the experiment result, we conclude that this new algorithm shortens the executing time of tasks and improves the system performance compared with other load algorithm.     

环保型可降解油墨色料的研究

通过对金属离子、显色母体进行筛选，并对显色母体进行化学修饰，可以制得多种色泽、并在温和条件下褪色的环保型可降解油墨色料。     

素环上的交换映射

设R是一个环,F:R→R是一个映射.如果对所有的x∈R,有[F(x),x]=0成立,则称F是R上的交换映射.文章的主要结论为:设R是特征不为2的素环.如果存在一个非零广义导子:δR→R,使得映射x→[δ(x),x]在R上是可变换的且δ(I)∈Z(R),则δ在R上是可交换的.     

不同剂量戊巴比妥钠对豚鼠听性脑干诱发电位的影响

目的比较不同剂量戊巴比妥钠麻醉对豚鼠听性脑干反应(ABR)测试的影响,探讨进行ABR测试最佳的戊巴比妥钠剂量。方法:16只(32耳)豚鼠按3%戊巴比妥钠(40mg/Kg)、3%戊巴比妥钠(30mg/Kg)、1%戊巴比妥钠(40mg/Kg)、1%戊巴比妥钠(30mg/Kg)麻醉剂量随机分为4组;采取腹腔注射麻醉,于每次麻醉后进行ABR测试;观察有关麻醉诱导时间、维持时间、呼吸频率、死亡例数及ABR反应阈、各波潜伏期及波间期。结果各组麻醉诱导时间及维持时间有显著性差异,其中3%戊巴比妥钠(40mg/Kg)组诱导时间最短、维持时间最长,1%戊巴比妥钠(30mg/Kg)组麻醉诱导时间稍长,而维持时间最短,但均超过2.5h。各组除Ⅱ波潜伏期、Ⅰ-Ⅱ、Ⅱ-Ⅲ波间期有显著性差异外,其余各波潜伏期和波间期、反应阈均无显著性差异。1%戊巴比妥钠(30mg/Kg)组在重复麻醉后各指标均无显著性差异,且无一例死亡,其余各组均有1-2只豚鼠死亡。结论对豚鼠腹腔注射1%戊巴比妥钠(30mg/Kg)即可达到较理想的麻醉效果,而且重复麻醉后不影响ABR测试结果。     

生物医学钛合金微弧氧化涂层的表面特征

通过在含有钙盐、磷盐的的电解液中对Ti-6Al-4V合金进行微弧氧化处理,在钛合金表面制备了含钙、磷元素的陶瓷层.采用扫描电镜(SEM)、X射线衍射仪(XRD)和能谱仪分析了涂层的形貌、相及元素组成.结果表明,Ti-6Al-4V合金表面的微弧氧化涂层是一种含钙磷元素、多孔、与基体结合牢固、具有陶瓷特性的混合物,其主要组成相为二氧化钛.经过六偏磷酸钠-乙酸钙工艺处理后的试样涂层中含有α-Ca(PO3)2、CaTiO3相.从物相的组成考虑,经过六偏磷酸钠-乙酸钙工艺处理后的涂层的生物活性更好.     

TSP203在某隧道DK1887＋238～DK1887＋126区段地质超前预报中的应用

本文采用TSP203对某隧道的地质条件进行探测,查明了掌子面前方围岩的地质情况、不良地质体的位置、工程性状、水文地质状况等信息,预报了隧道围岩级别,从而为施工阶段修正设计、施工支护材料的提早准备、防止可能的工程险情、采取合理的施工措施提供了有力保障。