Sequence similarity analysis of non-self CTL epitopes and mouse proteins using sequence alignment

This research analyzed amino acid sequence similarity between non-self T cell epitopes recognized by mouse antibodies and mouse proteins. Using sequence alignment,we found that only 8 of 1 108 epitopes are highly similar to mouse protein sequences. The result shows that non-self T cell epitopes are not similar or have little similarity to mouse protein sequences. Furthermore,reviewing the related literature,we also found that the eight epitopes would trigger immune responses in some particular environment,which are ignored by T cells in normal condition. The result suggests that no or low-similarity peptide vaccines can reduce the chance of collateral cross-reactions and enhance the antigen-specific immune response to vaccine.     

低空数码摄影测量的应用探讨

介绍了利用低空数码航测法生产3D产品的技术流程,以河南省新密市测区为例,从低空航测必备条件、技术参数等方面探讨了低空数码摄影测量生产3D产品的组织实施,并指出了目前航测法存在的不足之处。     

师生谈心高效之浅见

在平时的教学工作中,师生交流与沟通只要能重视方式方法,就能增进师生间相互理解、支持与配合,建立浓厚的师生感情,产生凝聚力、向心力,有利于良好学风的形成,促进学生身心健康发展.那么,教师应如何与学生谈心才能更高效呢.笔者对此进行了论述.     

Plasmonic biosensors and nanoprobes based on gold nanoshells

Gold nanoshells (GNSs), consisting of a dielectric core coated with gold, have gained extensive attention as they show readily tunable optical properties and good biocompatibility. As highly sensitive and label-free optical biosensors with wide applications, GNSs have been investigated in many fields including drug delivery, immunoassay, cancer treatment, biological sensing and imaging. Taking advantage of the adjustability of the local surface plasmon resonance (LSPR) and the sensitivity of the surfaceenhanced Raman scattering (SERS) signal of GNSs, we have developed diverse applications including plasmonic biosensors and nanoprobes based on GNSs. In this review we introduce plasmonic and electromagnetic properties and fabrication methods of GNSs. We describe research progress in recent years, and highlight several applications of GNSs developed by our group. Finally we provide a brief assessment of future development of GNSs as plasmonic materials that can be integrated with complementary analytical techniques.     

单-6-叠氮-β-环糊精与苯乙炔的点击化反应

利用CuI/NBS这种新型催化体系来促进单-6-叠氮-β-环糊精与苯乙炔之间的偶联反应,通过这个多组分反应可以高效地以炔和叠氮为原料一锅法制备5-碘代-1,4-取代-1,2,3-三氮唑类化合物.     

中小企业自主创新障碍及对策

创新是一个国家和一个地区经济发展的不竭动力，文章从中小企业在自主创新过程中的障碍入手，为中小企业如何提高自主创新能力提供建议。     

Inferring requirement goals from model implemented in UML

UML is used widely in many software development processes. However, it does not make explicit requirement goals. Here is a method tending to establish the semantic relationship between requirements goals and UML models. Before the method is introduced, some relevant concepts are described.     

论物权法平等保护原则的内涵

物权法作为民法典的一部分，其基本要求便是对权利人的权利进行平等保护。物权法首次将平等保护原则写入其中，是对《民法通则》第七十五条的深刻反思。必须改变传统民法对国家财产实行特殊保护的观念。公民合法取得的财产应当受到与对国家财产和集体财产同等的法律保护．使人民群众积累的财产能够受到切实的保障．这也是物权法引进这一原则的重要意义所在。鉴于此，有必要对这一原则的基本内容和科学内涵及应注意的问题作一些概括的分析。     

论《东皇太一》的神性及其艺术风格

<东皇太一>庄严肃穆、雍容富丽、热烈虔敬的艺术风格,极具感染力.这种独特的艺术风格形成的主要原因在于"东皇太一"至尊的神性.首先从祭祀仪式的特点来观照"东皇太一"的神性,然后从"太一"的称呼上来分析其至尊的神性,最后从"东皇"这个称呼以及它与"太一"相结合的角度再进一步来论述这个问题.     

浅谈企业人力资源管理的有效激励

人力资源是企业的第一资源和最重要的生产要素,文章从有效激励机制在企业人力资源管理中的作用,企业中影响有效激励的因素和实现激励的方法,以及激励问题对企业产生的负面影响,这四方面进行了阐述.