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991.
992.
以交易量、股价波动率和收益率的自相关性作为流动性、波动性和价格有效性等微观行为指标,实证分析了中国A股和B股市场在微观行为上的差异.结果发现,三个指标在两个市场之间存在显著差异.在B股向境内居民开放前,A股的三个指标都要显著大于B股.而B股开放之后,B股的这些指标都大于开放之前.最后运用行为金融理论中投资者结构对微观行为的影响进行了分析和解释. 相似文献
993.
994.
Microbial starch-binding domains (SBD) and granule-bound starch synthase I (GBSSI) are proteins which are accumulated in potato starch granules. The efficiency of SBD and GBSSI for targeting active luciferase reporter proteins to granules during starch biosynthesis was compared. GBSSI or SBD sequences were fused to the N- or C-terminus of the luciferase (LUC) gene, via an artificial Pro-Thr encoding linker sequence. The genes were introduced into an amylose-free (amf) potato mutant. It appeared that SBD was superior to GBSSI as a targeting sequence, mainly because the luciferase retained higher activity in the SBD-containing fusion proteins than in the GBSSI-containing ones. 相似文献
995.
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. 总被引:11,自引:0,他引:11
Michael G Anderson Richard S Smith Norman L Hawes Adriana Zabaleta Bo Chang Janey L Wiggs Simon W M John 《Nature genetics》2002,30(1):81-85
Pigmentary glaucoma is a significant cause of human blindness. Abnormally liberated iris pigment and cell debris enter the ocular drainage structures, leading to increased intraocular pressure (IOP) and glaucoma. DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment dispersion (IPD) and iris stromal atrophy (ISA). Using high-resolution mapping techniques, sequencing and functional genetic tests, we show that IPD and ISA result from mutations in related genes encoding melanosomal proteins. IPD is caused by a premature stop codon mutation in the Gpnmb (GpnmbR150X) gene, as proved by the occurrence of IPD only in D2 mice that are homozygous with respect to GpnmbR150X; otherwise, similar D2 mice that are not homozygous for GpnmbR150X do not develop IPD. ISA is caused by the recessive Tyrp1b mutant allele and rescued by the transgenic introduction of wildtype Tyrp1. We hypothesize that IPD and ISA alter melanosomes, allowing toxic intermediates of pigment production to leak from melanosomes, causing iris disease and subsequent pigmentary glaucoma. This is supported by the rescue of IPD and ISA in D2 eyes with substantially decreased pigment production. These data indicate that pigment production and mutant melanosomal protein genes may contribute to human pigmentary glaucoma. The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma. 相似文献
996.
以对苯半醌负离子自由基为模型 ,利用ESR技术研究黄酮类化合物清除自由基的作用 ,初步获得一些构效关系。 相似文献
997.
目的是将用于测量片状试样的热扩散率的激光闪光法推广至测量薄膜试样。应用 1 5纳秒脉冲 Nd:YAG激光及响应时间 0 .9微秒的 (Hg,Cd) Te红外探测器等建立了闪光法热扩散率测量系统 ,并应用此系统对微米量级厚度的不锈钢薄膜进行了测量。同时针对将激光闪光法应用于薄膜时所出现的问题 ,如激光的有限脉冲时间及有限吸收厚度效应 ,测量系统的滞后效应 ,以及增强红外吸收及辐射用表面黑化膜的影响进行了分析并提出了解决方法 相似文献
998.
为获得眼镜王蛇(Ophiophagus hannah,简称Oh)蛇毒α-神经毒素(α-NT)的基因序列,依据眼镜蛇科不同毒蛇种类来源的α-NT基因有较高的同源性,设计1对上下游引物,为克服引物带来模糊扩增,在蛋白编码部分再设计1对上下游特异引物,用Nacleospin RNA Kit法从3条活眼镜王蛇毒腺中提取mRNA,以3′端引物合成的cDNA作为模板进行PCR扩增反应,测定产物的核苷酸序列,得到全长474bp的眼镜王蛇cDNA基因核苷酸序列。该核苷酸序列的信号肽与眼镜蛇树属Pseudonnaja textilis(Pt)、海蛇Laticauda semifasciata(Ls)100%同源,与眼镜蛇南洋亚种Naja sputatrix (Ns)、银环蛇(Bungarus multicinctus)(Bm)96.8%同源;蛋白密码部分有83.3%与Ns、79.2%与Pt、76.4%与Ls、74.1%与Bm同源。信号肽后紧接着的72个氨基酸有90.3%与已发现的眼镜王蛇毒长链α-NT Toxin a同源,大约有73.6%与Toxin b、69.7%与Oh-4、66.7%与Oh-5、56.9%与Oh-6A和6B同源,并与α-银环蛇毒素54.2%同源。说明新发现的眼镜王蛇cDNA是一条长链α-NT基因。 相似文献
999.
B.Wünnemann 《科学通报(英文版)》2002,47(23):1946-1956
Comprehensive field investigations and laboratory analyses show that palaeolakes, including fresh- mesohaline water Megalake Tengger and other semi-con- nected, isolated water bodies, during late Pleistocene covered an area of more than 20000 km2, which is more than half of the Tengger Desert in NW China. Stratigraphic correlation and chronological evidence indicate that before ca. 42000 aBP the area was more arid. The palaeolakes started to develop around 40000 uncal. 14C aBP but until 37000 14C aBP their scope was limited. High water levels established from 35000 14C aBP lasted until 22000 14CaBP. Lake levels regressed between 22000 and 20000 14C aBP but transgressed from 20000 to 18600 14C aBP. Subsequently, water level declined further and the Megalake Tengger finally desiccated at around 18000 14C aBP. Megalake Tengger possessed a fresh-mesohaline water property, implying that the regional precipitation increased significantly. During the period of Megalake Tengger, the climate was warmer-humid than present. The annual rainfall was 250 to 350 mm more than that of today and the temperature was 1.5 to 3.0℃ higher. 相似文献
1000.
Zircon (U-Th)/He thermochronological constraints on Cretaceous thermal extension of Dabieshan orogen 总被引:1,自引:0,他引:1
:(U-Th)/He ages of 13 samples from Yuexi-Luotian core and its flanks in Dabieshan orogen fall in the range of 155~85 Ma. He ages for samples from the core range between 85~107 Ma, while those from the flanks range between 114~155 Ma. The result shows that the Yuexi-Luotian core was a thermal dome in Cretaceous with core temperature being much higher than those of the flanks. The thermal extension which resulted in the formation of Dabie core complex lasted until ca. 85 Ma. The magnitude of exhumation in the core is approximately 1528.8 m more than that in the flanks. 相似文献