全文获取类型
收费全文 | 28865篇 |
免费 | 80篇 |
国内免费 | 158篇 |
专业分类
系统科学 | 139篇 |
丛书文集 | 499篇 |
教育与普及 | 42篇 |
理论与方法论 | 100篇 |
现状及发展 | 13451篇 |
研究方法 | 1278篇 |
综合类 | 13198篇 |
自然研究 | 396篇 |
出版年
2013年 | 269篇 |
2012年 | 411篇 |
2011年 | 809篇 |
2010年 | 168篇 |
2008年 | 523篇 |
2007年 | 576篇 |
2006年 | 576篇 |
2005年 | 535篇 |
2004年 | 538篇 |
2003年 | 498篇 |
2002年 | 499篇 |
2001年 | 936篇 |
2000年 | 865篇 |
1999年 | 615篇 |
1992年 | 595篇 |
1991年 | 414篇 |
1990年 | 486篇 |
1989年 | 494篇 |
1988年 | 460篇 |
1987年 | 546篇 |
1986年 | 474篇 |
1985年 | 596篇 |
1984年 | 484篇 |
1983年 | 364篇 |
1982年 | 340篇 |
1981年 | 367篇 |
1980年 | 462篇 |
1979年 | 889篇 |
1978年 | 757篇 |
1977年 | 740篇 |
1976年 | 611篇 |
1975年 | 632篇 |
1974年 | 845篇 |
1973年 | 756篇 |
1972年 | 779篇 |
1971年 | 840篇 |
1970年 | 1073篇 |
1969年 | 813篇 |
1968年 | 820篇 |
1967年 | 795篇 |
1966年 | 681篇 |
1965年 | 472篇 |
1964年 | 156篇 |
1959年 | 249篇 |
1958年 | 440篇 |
1957年 | 292篇 |
1956年 | 259篇 |
1955年 | 246篇 |
1954年 | 239篇 |
1948年 | 162篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
341.
Human β-defensins 总被引:1,自引:0,他引:1
Pazgier M Hoover DM Yang D Lu W Lubkowski J 《Cellular and molecular life sciences : CMLS》2006,63(11):1294-1313
342.
Nodal signals pattern vertebrate embryos 总被引:4,自引:0,他引:4
Vertebrate embryonic patterning requires several conserved inductive signals–including Nodal, Bmp, Wnt and Fgf signals. Nodal,
which is a member of the transforming growth factor β (TGFβ) superfamily, activates a signal transduction pathway that is
similar to that of other TGFβ members. Nodal genes, which have been identified in numerous vertebrate species, are expressed
in specific cell types and tissues during embryonic development. Nodal signal transduction has been shown to play a pivotal
role in inducing and patterning mesoderm and endoderm, and in regulating neurogenesis and left-right axis asymmetry. Antagonists,
which act at different steps in the Nodal signal transduction pathway, have been shown to tightly modulate the inductive activity
of Nodal.
Received 20 October 2005; received after revision 15 November 2005; accepted 25 November 2005 相似文献
343.
Bosch-Comas A Lindsten K Gonzàlez-Duarte R Masucci MG Marfany G 《Cellular and molecular life sciences : CMLS》2006,63(6):723-734
The biological functions of the more than one hundred genes coding for deubiquitinating enzymes in the human genome remain
mostly unknown. The USP25 gene, located at 21q11.2, encodes three protein isoforms produced by alternative splicing. While
two of the isoforms are expressed nearly ubiquituously, the expression of the longer USP25 isoform (USP25m) is restricted
to muscular tissues and is upregulated during myogenesis. USP25m interacts with three sarcomeric proteins: actin alpha-1 (ACTA1),
filamin C (FLNC), and myosin binding protein C1 (MyBPC1), which are critically involved in muscle differentiation and maintenance,
and have been implicated in the pathogenesis of severe myopathies. Biochemical analyses demonstrated that MyBPC1 is a short-lived
proteasomal substrate, and its degradation is prevented by over-expression of USP25m but not by other USP25 isoforms. In contrast,
ACTA1 and FLNC appear to be stable proteins, indicating that their interaction with USP25m is not related to their turnover
rate.
Received 7 November 2005; received after revision 7 January 2006; accepted 13 January 2006 相似文献
344.
345.
Relation between total and exchangeable sodium in the body 总被引:1,自引:0,他引:1
346.
基于EXCEL和MATLAB的矩形薄片热传导计算与仿真研究 总被引:1,自引:0,他引:1
对二维导热问题进行了离散化研究,推导出了节点差分方程,以矩形薄片为例,用MS.Excel对节点温度进行了计算,用MATLAB对计算结果进行了仿真,得到了薄片的温度分布仿真图. 相似文献
347.
Conclusion The optimum wavelength of Nd3+-doped double-clad fiber laser or amplifier made in China is near 830 nm. The efficiency of Nd3+-doped double-clad fiber devices pumped by 820-nm laser is low due to ESA. In order to increase the photochemical stability
of the outer cladding, the material of the outer cladding must be advanced. 相似文献
348.
Expression of lysine-rich protein gene and analysis of lysine content in transgenic wheat 总被引:2,自引:0,他引:2
MENGChaomin CHENXuqing LIANGRongqi YANGFengping ZHANGLiquan ZHANGXiaodong CHENTianyou S.S.M.Sun 《科学通报(英文版)》2004,49(19):2053-2057
Expression vector pBPC102, which carries winged bean lysine-rich protein (wblrp) gene and dihydropicolinate synthase (DHDPS) gene, was transferred into hexaploid winter wheat cv. Jinghua No.l, Jing411, You899 and Yangnongl5 explants of immature inflorescence and immature embryos by particle bombardment. More than 100 transgenic plants were obtained under the selection of s-(2-aminoethyl)-L-cysteine (AEC). Confirmed transgenic plants of To and TI generation by PCR and PCR-Southern blotting analyses showed successful integration of wblrp gene into wheat genome. Analysis of transgenic plant lines of T2 by Northern dot-blotting showed good expression of wblrp gene in offspring seed. The content of free lysine in leaves, contents of bound lysine and total proteins in seeds of T2 transgenie wheat lines were determined and analyzed. Among 34 tested transgenic lines, levels of free lysine content in leaves of 9 transgenic lines are 2~3times higher than un-trans-formed wild-type cultivars. Among 17 analyzed transgenic lines, bound lysine content of 4 transgenic lines is more than 10% higher than that of wild-type cultivars. Our research suggests that introducing wblrp gene into wheat is an effective way to improve its nutrition quality. 相似文献
349.
Yan M Zhaoxin Du Xiaoming Cui Jun Cheng Guolong Liu Tianhao Gong Huimin Liu Xiaopeng Wang Yuyong Chen 《自然科学进展(英文版)》2018,28(6):711-717
The microstructure and mechanical properties of Ti-3.5Al-5Mo-6V-3Cr-2Sn-0.5Fe high strength titanium alloy sheets prepared by unidirectional cold rolling and two-step cross cold rolling were investigated. Results showed that the β phase grains were refined significantly by cold rolling followed by solution treatment for a short time.Compared to unidirectional cold rolling, the short time solution treatment after two-step cross rolling could significantly reduce the non-uniformity of the microstructure of the alloy sheets. After aging treatment at 550 ℃,the anisotropy of the mechanical properties still existed in the unidirectional rolled sheets, and the tensile strength was highest along the rolling direction. After solution and aging treatment, the anisotropy of the mechanical properties of the two-step cross rolling process sheet was not obvious than unidirectional cold rolling,and alloy had good strength and plasticity matching. 相似文献
350.
YunHui Hu XiaoHua Deng Meng Zhou RongXin Tang Hui Zhao Song Fu ZhiWen Su JingFang Wang ZhiGang Yuan R. Nakamura W. Baumjohann H. R. Eme C. M. Carr 《科学通报(英文版)》2008,53(12):1880-1886
Magnetic reconnection is a very important and fundamental plasma process in transferring energy from magnetic field into plasma. Previous theory, numerical simulations and observations mostly concentrate on 2-dimensional (2D) model; however, magnetic reconnection is a 3-dimensional (3D) nonlinear process in nature. The properties of reconnection in 3D and its associated singular structure have not been resolved completely. Here we investigate the structures and charactedstics of null points inside the reconnection diffusion region by introducing the discretized Poincar6 index through Gauss integral and using magnetic field data with high resolution from the four satellites of Cluster mission. We estimate the velocity and trajectory of null points by calculating its position in different times, and compare and discuss the observations with different reconnection models with null points based on characteristics of electric current around null points. 相似文献