Comparative and statistical analysis of nAChR sequences: An <Emphasis Type="Italic">ab initio</Emphasis> approach to the origin of molecular discrimination

Compared with traditional structure-based approaches for the identification of species-specific ligands, the ab initio approach, based on large-scale protein sequences from different species, has been used to locate specific sites that may be important to the molecular selectivity of species. Statistically significant differences in the distribution of residues in different species and differences in the physicochemical properties of residue-specific sites may largely account for species selectivity. The nicotinic acetylcholine receptor (nAChR), an important neuro-receptor with significantly different ligand selectivity in different species, was used to test our method. Because of the lack of nAChR structural information, the mechanism of ligand discrimination is unclear which hinders attempts at novel molecular design. In this study, the specific site residues 186 and 189 in the principal subunits and residues 34, 55, 56, 57, 106 and 112 in complementary subunits of nAChR were identified by applying our method with stringent statistical cutoffs. These sites were predicted to contribute to ligand selectivity and this result coincides well with the known experimental data.     

一种非线性调频波形优化设计算法

将遗传算法与动态优选法相结合，构成了一种新的算法，该算法能够有效抑制非线性调频信号通过匹配滤波器后产生的旁瓣，最后与数值法和动态优选法进行了比较。     

压力容器带防腐层表面磁粉探伤的研究

采用人工裂纹试样的方法，模拟压力容器涂刷油漆防腐层的状况进行磁粉探伤，得出了油漆防腐层厚度与裂纹检出灵敏度的定量关系；结合ＣＶＤＡ《压力容器缺陷评定》规范，探讨了实验方法对一般在役压力容器不除去油漆的情况下进行磁粉探伤检验的可行性。     

巩河水库正常溢洪道裂缝成因研究

结合巩河水库加固工程正常溢洪道发生裂缝的工程实际，应用弹塑性有限元法研究了大坝在渗流及加固施工过程共同影响下的工作状态，探讨了其正常溢洪道裂缝成因．     

内掺氧化钡对贝利特型水泥性能的影响

本文应用化学分析、XRD、SEM、EDAX、IR等测试手段,研究了在多种组分存在的条件下,内掺BaO对C_2S-C_4A_3-C_4AF-C系统矿物组成及性能的影响。     

γ射线BGO探头研制

为钢厂连铸液位监测研制了一种 BGO探头 ,它由一个 D2 5× 2 5 BGO晶体、一支 CR1 1 0光电倍增管和在探头内的电子线路构成。其工作点电压选约 90 0 V,输出脉冲幅度 1 0 V,脉冲宽度 5μs,本底计数 :5 0± 7s- 1 。用 1 .6μs V/h伽马射线照射 ,计数 :45 0± 2 1 s- 1 ,长期工作稳定 ,计数无漂移 ,具有防震、抗磁、耐高温等特点     

Modeling of Busbars in High Power Neutral Point Clamped Three-Level Inverters

The busbars in high power neutral point clamped three-level inverters are modeled using the Maxwell Q3D Extractor software, which is based on the partial element equivalent circuits method. The equivalent circuits of the busbars and devices model are simulated in the electric simulator PSlM to analyze the effects of the parasitic inductance on the switching characteristics of the integrated gate commutated thyristor （IGCT） in different topology positions. The simulation results agree well with the measured impedance analyzer results and the IGCT test results, which proves the effectiveness of the modeling method for the large, complex busbars.     

等值线图数据采集与处理软件的研制

本文从曲面造型设计工作需要出发,提出一种曲面的平面等高线图拟合及展开曲面的算法,并开发了等高线图数据采集与处理的软件。