Signal transduction pathways mediated by colony stimulating factor-1 receptor

Colony-stimulating factor-1 (CSF-1), which is necessary for cell proliferation and differentiation, regulates both immediate and delayed early responses throughout G1 phase. The binding of CSF-1 to its receptor (CSF-1R) triggers phosphorylation of the receptor and its intrinsic tyrosine kinase. The activated receptor binds directly to cytoplasmic effector proteins, which induce multiple-signal transduction pathways. CSF-1 can induce the c-myc gene expression via Ras and Ets-related proteins. The expression of c-fos/jun family genes is also targeted following the activation of Ras. CSF-1R activates STAT1 and STAT3 to participate in signaling, but JAKs do not appear to contribute to signaling by CSF-1R. CSF-1R activates PI3-kinase, and PI3-ki can interact with downstream proteins by the MAPKK-related pathway independent of Ras/Raf. PC-PLC can enforce signaling in response to CSF-1. Furthermore, the turnover and dephosphorylation by the phosphatase SHPTP1 of CSF-1R are the major mechanism in the negative regulation of signaling by CSF-1R     

Diamond synthesis from a system of chromium-carbide and Ni70Mn25Co5 alloy

In order to ascertain the mechanism of interaction between carbide and metallic catalyst and formation of diamond under high pressure and high temperature, and find a new method to synthesize diamond with special properties, it is necessary to investigate the reaction behavior of different carbides and metallic solvent_catalysts under high pressure and high temperature. A system of Cr-3C-2 powder and Ni 70Mn 25Co 5 alloy in weight ratio of 1∶6 was treated under 6 0 GPa and 1 500℃ for 20, 30 or 60 min respectively. X_ray diffraction of the samples indicated the Cr 3C 2 decomposed partially after high pressure and temperature treatment, and Cr 7C 3, Cr and diamond formed respectively. There was not any trace of graphite in the samples. The result suggested that the separated carbon atoms could form diamond directly without conversion process of graphite into diamond. The observation of SEI, WDX and EDX also showed that diamond crystals were synthesized in the system, which have perfect surfaces and shapes, with the average grain size of about 40 μm. The properties of the crystals are being investigated.     

Relationship between giant magnetoresistance of NiFe/Cu multilayers and their microstructures

The (111)-orientated NiFe/Cu multilayers were prepared by magnetron sputtering method. At room temperature, saturation magnetoresistances of NiFe/CU multilayers oscillate as a function of Cu spacer layer thickness. Two peak GMR values of 19.4%, 11.6% and 11.2%, 1% appear, respectively, at Cu sublayer thickness of t_Cu,= 1.0, 2.2 nm while the deposition pressures are 0.25 and 0.45 Pa. X-ray small-angle reflections and diffuse scattering at Cu K-edge (8.979 keV) by synchrotron radiation source were used to characterize the interfacial roughness. Diffraction anomalous fine-structure scattering (DAFS) was performed to investigate the local structure of NiFe and Cu sublayers. Results show that the deposition pressure has effect on interfacial roughness of the samples obviously, and the interfacial roughness also affects the GMR values of the samples strongly.     

Preliminary study on climatic signals of stable isotopes from Holocene speleothems under monsoon condition

Within the East Asian monsoon zone the change in oxygen isotope of Holocene stalagmite is mainly related to monsoon rain rather than to temperature. And carbon isotope can be taken as a comprehensive signal which contains the natural information and the information of anthropogenic activity. Isotopic analysis is also compared with the annual layer records.     

正蕴涵BCK-代数的伴随半群

本文讨论了正蕴涵BCK－代数的剩余刻划;证明了具有条件（S）的正蕴涵BCK－代数的伴随半群是一个下半格。     

Search for new antiphytovirucides

The lead compound of substituted 2-(4′-hydroxyphenyl)benzimidazoles were modified by phosphorylation sulfonation and carboxymethylation. The benzimidazoloamidophosphate (6) (7) have better activity against tobacco mosaic virus (TMV). The benzimidazolophenoxyacetic acid, phenoxysulfonic acid containing trifluoromethyl, and nitro group have 77%≈85% efficiency for wheat rust disease. Supported by the National Natural Science Foundation of China and National Laboratory of Elemento Organic Chemistry Nankai University Qu Fanqi: born in 1952, Associate professor     

炸药破碎岩石能量利用率的研究

以爆炸动力学理论和岩石断裂理论为基础,分析了岩石破中的能量平衡问题,并给出了炸药破碎岩石能量利用率的计算方法。理论分析表明,平均爆破块度随岩石的单位表面能的增加而增加;计算结果表明,炸药破碎岩石能量利用率仅占炸药总能量的百分之十左右。     

强受限半导体量子点的形状对受限激子的影响

在有效质量近似下,采用无限深势阱模型研究了强受限范围内球形、圆柱形、立方形半导体量子点的形状对受限激子的影响。结果表明对于采用体激子的等效Ｒｙｄｂｅｒｇ能量Ｒ＾＊比较大的材料制备的量子点,其形状带来的影响是显著的。     

连续驱动摩擦焊负载等效电气特性的研究

通过对连续驱动摩擦焊能量参数的计算机实时、同步检测,经过计算发现：摩擦焊负载的电气特性并不是纯电阻特性（耗能特性）,而是表现出阻容双重特性（耗能和储能特性）．经理论分析认为,负载的电容特性（储能特性）是由于工件在摩擦扭矩的作用下,产生弹性扭转变形并储存了主电机供给的机械能所造成．研究结果有利于方便实现连续驱动摩擦焊过程的数值模拟,为深入研究连续驱动摩擦焊过程的本质打下了坚实的基础．     

硒水平对食管癌发病率影响的初步研究

对比研究显示食管癌高发区磁县土壤,粮食,水和正常人发硒的质量分数「分别为０．４２＊１０＾－９,０．０８＊１０＾－９,１．２４＊１０＾－９,１．１６＊１０＾－６」最高,中发区临漳县次之「分别为０．１７４＊１０＾－９,０．０４９＊１０＾－９,０．６８＊１０＾－９,０．９７＊１０＾－６」,低发区魏县最低「分别为０．１４８＊１０＾－９,０．０２６＊１０＾－９,０．２４＊１０＾－９,０．９１＊１０＾－６」,