基于距离函数的3种夹具定位分析方法的比较

建立了点—面、面—面有向距离函数的一阶、二阶微分表达式的统一理论模型.在此理论模型的基础上提出了线性方法(基于点面距离函数一阶微分性质)、单边二次方法(基于点—面距离函数一、二阶微分性质)和双边二次方法(面—面距离函数一、二阶微分性质)的3种夹具定位分析方法,进而分析了定位元和工件的局部曲率对夹具定位精度的影响.仿真试验表明:当定位元的曲率半径相对于工件的曲率半径较小时,3种分析方法的精度相当;但当定位元的曲率半径相对于工件的曲率半径较大时,线性方法、单边二次方法不能跟踪理论值的变化,而双边二次方法却能很好地跟踪理论值的变化,表明了双边二次模型的高精度特性.     

积分复位控制三相功率因数校正

介绍了一种工作于连续导电模式的三相功率因数校正电路，对其控制方程进行详细的推导，并用积分复位控制电路进行实现。积分复位控制电路由-可复位积分器，-RS触发器和-比较器组成控制电路的核心器件，结构十分简单。积分复位控制三相功率因数校正具有下述特点：常频控制，这有利于滤波器的设计；控制电路简单，不需要乘法器；控制思路清晰，控制效果好。仿真结果证明了理论分析的正确性。     

《史记·律书》律数匡正：—兼论先秦管律

《史记·律书》有“黄钟长八寸七分一，宫”的一组律数，至迟从唐代起，人们就把它看作一组弦律数据，并以为原数据甚误而不可解，从而校正勘误。本文经过严格推算后指出：１．该组律数不是弦律。而是管律；２．该组律数的原数据基本上没有错，尤其是“黄钟长八寸七分一”是完全正确的黄钟管长，由于历代校勘家不辨弦律与管律之别，书“七”字改为“十”字，从而认为《律书》中这段文字“误七句、衍二字”，历代的校改本质上是错误的；３．在历代传抄翻刻《史记》的过程中，律数原数据中有三律的律位与数值被窜乱。在更正被窜乱了的这三律之后，作者对原数据小作校正，并补正了原数据中遗漏和误植的二律数值，恢复了《史记》所载的先秦管律的本来面目。     

Convergent dental adaptations in pseudo-tribosphenic and tribosphenic mammals

Tribosphenic molars of basal marsupials and placentals are a major adaptation, with the protocone (pestle) of the upper molar crushing and grinding in the talonid basin (mortar) on the lower molar. The extinct pseudo-tribosphenic mammals have a reversed tribosphenic molar in which a pseudo-talonid is anterior to the trigonid, to receive the pseudo-protocone of the upper molar. The pseudo-protocone is analogous to the protocone, but the anteriorly placed pseudo-talonid is opposite to the posterior talonid basin of true tribosphenic mammals. Here we describe a mammal of the Middle Jurassic period with highly derived pseudo-tribosphenic molars but predominantly primitive mandibular and skeletal features, and place it in a basal position in mammal phylogeny. Its shoulder girdle and limbs show fossorial features similar to those of mammaliaforms and monotremes, but different compared with those of the earliest-known Laurasian tribosphenic (boreosphenid) mammals. The find reveals a much greater range of dental evolution in Mesozoic mammals than in their extant descendants, and strengthens the hypothesis of homoplasy of 'tribosphenic-like' molars among mammals.     

超弹性膜的等轴拉伸试验方法及仿真

提出了一种针对超弹性膜材料的等轴对称拉伸试验装置,介绍了等轴拉伸试验的原理和方法,并对等轴拉伸试验条件及数据处理进行了分析,最后运用有限元软件ABAQUS对等轴理想拉伸、边角拉伸点不固定的自由拉伸、边角点固定的等轴拉伸3种等轴拉伸方法进行仿真.结果表明,边角点固定的等轴拉伸方法在较大拉伸试验范围内的误差较小,可以满足材...     

上海建设海上人工岛及长江口亚三角洲体系的战略意义

近代上海的崛起,依靠的是地处我国弓箭型江海格局关节点的独特区位优势.在上海发展的历史轨迹中,有三个重要的交汇点:即苏州河与黄浦江、黄浦江与长江、长江与东海的汇合处.在第一个交汇点上,形成了以外滩为标志的近代繁华;在第二个交汇点处,包括宝钢、外高桥以及浦东新区,带动了上海改革开放30年的蓬勃发展;而第三个交汇点,就是浩瀚的长江口.     

浅谈加气混凝土砌块施工质量问题及防治措施

文章主要探讨造成加气混凝土砌块墙体裂缝;加气混凝土外墙渗水和加气混凝土填充墙抹灰层空鼓、脱落等三大问题的原因,并就这三大问题提出了具体的防治措施,为以后的施工提供借鉴。     

锂离子电池失效的快速判定

通过锂离子单体电池的循环寿命实验,分析了该电池的充放电电流,电压以及内阻随循环次数的老化特性.研究发现,随着充放电次数的增加,电池在恒流阶段充入的容量占总容量的百分比的变化趋势和电池内阻变化相一致,因此可以根据恒流充电的时间来快速判定电池的衰减程度.     

Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2

A combined genome-wide association and linkage study was used to identify loci causing variation in cystic fibrosis lung disease severity. We identified a significant association (P = 3.34 × 10(-8)) near EHF and APIP (chr11p13) in p.Phe508del homozygotes (n = 1,978). The association replicated in p.Phe508del homozygotes (P = 0.006) from a separate family based study (n = 557), with P = 1.49 × 10(-9) for the three-study joint meta-analysis. Linkage analysis of 486 sibling pairs from the family based study identified a significant quantitative trait locus on chromosome 20q13.2 (log(10) odds = 5.03). Our findings provide insight into the causes of variation in lung disease severity in cystic fibrosis and suggest new therapeutic targets for this life-limiting disorder.     

Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder

Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.