异烟肼-柚皮素共晶的表征及其性能研究

以抗结核药异烟肼和黄酮类天然产物柚皮素为原料,采用混悬法制得异烟肼-柚皮素的药物-药物共晶。通过XRPD、DSC、FTIR、SSNMR和LNMR等分析技术对共晶产物进行了表征,分析了共晶分子间的氢键作用,确定了共晶中异烟肼和柚皮素的比例;对异烟肼、柚皮素和共晶在模拟生理液中的表观平衡溶解度进行了比较研究。结果表明,异烟肼的酰肼基和吡啶氮与柚皮素上的3个羟基在共晶中形成了新的氢键,共晶产物中异烟肼与柚皮素的摩尔比为1∶1;共晶能大幅降低异烟肼的表观平衡溶解度,提高柚皮素的表观平衡溶解度,说明所得共晶能够在保留异烟肼抗结核药效的同时,减弱肝损伤,药理作用明显。     

Alkaline digestion behavior and alumina extraction from sodium aluminosilicate generated in pyrometallurgical process

In pyrometallurgical process, Al-and Si-bearing minerals in iron and aluminum ores are easily transformed into sodium aluminosilicates in the presence of Na₂O constituents, which alters the leaching behaviors of Al₂O₃ and SiO₂. It was confirmed that sodium aluminosilicates with different phase compositions synthesized at various roasting conditions were effectively digested in the alkaline digestion process. Under the optimum conditions at temperature of 100-120℃, liquid-to-solid ratio (L/S) of 10:2 mL/g, caustic ratio of 4, and Na₂O concentration of 240 g/L, the actual and relative digestion ratio of Al₂O₃ from the synthesized sodium aluminosilicates reached maximums of about 65% and 95%, respectively, while SiO₂ was barely leached out. To validate the superior digestion property of sodium aluminosilicate generated via an actual process, the Bayer digestion of an Al₂O₃-rich material derived from reductive roasting of bauxite and comprising Na_1.75Al_1.75Si_0.25O₄ was conducted; the relative digestion ratio of Al₂O₃ attained 90% at 200℃.     

Improved hemimorphite flotation using xanthate as a collector with S(Ⅱ) and Pb(Ⅱ) activation

The flotation of hemimorphite using the S(Ⅱ)–Pb(Ⅱ)–xanthate process, which includes sulfidization with sodium sulfide, activation by lead cations, and subsequent flotation with xanthate, was investigated. The flotation results indicated that hemimorphite floats when the S(Ⅱ)–Pb(Ⅱ)–xanthate process is used; a maximum recovery of approximately 90% was obtained. Zeta-potential, contact-angle, scanning electron microscopy–energy-dispersive spectrometry (SEM–EDS), and diffuse-reflectance infrared Fourier transform spectroscopy (DRIFTS) measurements were used to characterize the activation products on the hemimorphite surface and their subsequent interaction with sodium butyl xanthate (SBX). The results showed that a ZnS coating formed on the hemimorphite surface after the sample was conditioned in an Na₂S solution. However, the formation of a ZnS coating on the hemimorphite surface did not improve hemimorphite flotation. With the subsequent addition of lead cations, PbS species formed on the mineral surface. The formation of the PbS species on the surface of hemimorphite significantly increased the adsorption capacity of SBX, forming lead xanthate (referred to as chemical adsorption) and leading to a substantial improvement in hemimorphite flotation. Our results indicate that the addition of lead cations is a critical step in the successful flotation of hemimorphite using the sulfidization–lead ion activation–xanthate process.     

Influence of minor boron on the microstructures of a second generation Nibased single crystal superalloy

Boron is added into single crystal superalloys as a micro-alloying element to strengthen low angle grain boundaries.However,systematic investigations on the effect of boron on microstructures of single crystal superalloys are limitedly reported.The effect of boron on as-cast and heat-treated microstructures was investigated in two experimental Ni-based single crystal superalloys containing 3 wt% Re.The current results indicated that the volume fraction of(γ+γ′)eutectic and M_3B_2 borides was evidently increased,while the number of micropores was evidently decreased with the addition of 0.02 wt% boron.The(γ+γ′)eutectic could not be dissolved completely due to the lower incipient melting temperature caused by the formation of M_3B_2 borides.Meanwhile,the M_3B_2 borides were found to be enriched with indispensable strengthening elements Cr,Mo,W and Re,and this may lower the strengthening effect and cause stress concentration during high temperature creep.     

System deployment optimization in architecture design

Optimization of architecture design has recently drawn research interest. System deployment optimization （SDO） refers to the process of optimizing systems that are being deployed to activi- ties. This paper first formulates a mathematical model to theorize and operationalize the SDO problem and then identifies optimal so- lutions to solve the SDO problem. In the solutions, the success rate of the combat task is maximized, whereas the execution time of the task and the cost of changes in the system structure are mini- mized. The presented optimized algorithm generates an optimal solution without the need to check the entire search space. A novel method is finally proposed based on the combination of heuristic method and genetic algorithm （HGA）, as well as the combination of heuristic method and particle swarm optimization （HPSO）. Experi- ment results show that the HPSO method generates solutions faster than particle swarm optimization （PSO） and genetic algo- rithm （GA） in terms of execution time and performs more efficiently than the heuristic method in terms of determining the best solution.     

李渔从绘画到戏曲的身份认同

李渔是中国古代著名的文化艺术大家,毕生直面社会经济发展潮流,绘画理论与实践根置现实,执着无待而兴;与此同时,通过实施直观实用的创作原则,绘画向戏曲渗透,艺术向谋生齐观,获得了戏曲上的独特建树,充分体现了李渔从绘画到戏曲的身份认同,以及商品经济价值取向。李渔从绘画到戏曲具有强烈的商品经济意识与动机,所含审美理想与经济实用兼而有之,给予当今人们有益的启迪。     

非连通图3C8m∪C8m-1∪G的优美标号

研究非连通图3C8m∪C8m-1∪G的优美性.证明如下结论：对任意正整数m,若图G是特征为k且缺标号值k＋24m-2的交错图,则非连通图3C8m∪C8m-1∪G存在缺标号值k＋1的优美标号.     

浅谈隧道锚喷混凝土的施工技术

公路隧道锚喷支护是将锚杆与喷射混凝土作为加强和利用围岩自身支撑能力,文章结合多次隧道施工、实践经验,介绍了常用锚杆的安设、喷射混凝土作业过程及喷枪头施工操作注意事项。     

Upper bounds of differential characteristic probability for unbalanced Feistel network employing DSM

In this paper, for the unbalanced Feistel network which employs diffusion matrices in a switching way, we study the fixed number of its differential active S-boxes. Firstly we obtain some lower bounds of the differential active S-boxes for m, 2m and 3m rounds of Feistel structure, respectively. By concatenating these rounds, a fixed number of differential active S-boxes for arbitrary round number is derived. Our results imply that the unbalanced Feistel network using DSM is more secure than the traditional structure.