Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140?mm?Hg systolic blood pressure or ≥90?mm?Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.     

短基线定位算法的设计与实现

以用于水池内的短基线定位系统,对船模进行精确定位为研究对象,建立了解算的定位数学模型,仿真和水池实验结果证明了理论的准确性和工程的可行性.并且从理论上分析了产生误差的原因,进行了仿真分析.     

松花江哈尔滨段硅藻植物初报

本文报道了松花江哈尔滨段硅藻门植物,共发现100个分类单位,包括57种40变种3变型,分别隶属于2纲6目9科23属,初步分析了松花江哈尔滨段硅藻植物群落的种类组成及生态类型,大部分的硅藻属于普生种类,同时出现了一些喜酸种类如:Melosira granulate(Ehr．)Ralfs,Navicular viridula var．rostellata (Kutz．)Cl,Stauroneis anceps Ehr,Eunotia major W．Smith．等,还有少量的嗜碱性种类出现．     

固定化植物酯酶-显色剂传感膜的制备与性能

采用聚乙烯醇(PVA)与四乙氧基硅烷(TEOS)通过原位溶胶-凝胶法制备了PVA/SiO2有机/无机杂化溶胶,并将显色剂和植物酯酶分散于溶胶中,干燥成膜,得到一类透明度高、亲水-亲丙酮性可调、贮存性好的传感膜.该传感膜在乙酸-α-萘酯溶液中,会于可见光520 nm处出现一个新的吸收峰.传感膜在制备后的12天内活性明显下降,之后基本保持稳定,并且冷藏活性下降率要比室温保存的小很多.但不论是冷藏还是在室温下保存,被固定在杂化膜中的酶活稳定性都比在溶液状态下的明显提高.     

Optimal control of multisolution ordinary differential equations in the absence of convexity

<正> In this paper,the authors study an optimal control problem governed by a class of multistateordinary differential equations in the absence of convexity.To overcome the difficulty that thecorresponding approximate optimal control problem may have no solution,relaxed controls are introduced.With the help of relaxation theory,Pontryagin's maximum principle for the optimal pairs ofthe original control problem is obtained.In the end of this paper,the authors discuss the applicationof the maximum principle by an example.     

构建以职业生涯需求为主导的就业指导体系

大学生处于职业生涯发展的探索期,其职业发展既有理想的成分,又不得不考虑现实条件的限制.因此,大学生的职业生涯发展有其特殊的需求.针对大学生职业生涯发展的特殊需求,开展全程化就业指导,是构建当前高校就业指导体系的有效策略.     

Assignment of the μ4-O5 atom in catalytic center for water oxidation in photosystem II

The detailed structure of catalytic center of water oxidation, Mn4Ca-cluster, in photosystem ⅡI (PSII) has been reported recently. However, due to the radiation damage induced by X-ray and the complexity of the Mn4Ca-cluster, the assignment of the μ4-O5 atom coordinated by three Mn and one Ca2+ ions is still lack of essential evidences. In this article, we synthesized one Mn complex containing two μ4-O atoms. It is found that the lengths of all μ4-O-Mn bonds in this Mn complex are in the range of 1.89-2.10 , which are significantly shorter than 2.40-2.61 distance of μ4-O5-Mn bonds in Mn4Ca-cluster observed in the crystal structure of PSII. In addition, DFT calculations have been carried out on the Mn4Ca-cluster. It is found that the O atom of μ4-O or μ4-OH always trends to deviate from the center position of four metal ions, resulting in unequal bond lengths of four μ4-4-M (M=Mn or Ca), which is obviously different with larger and nearly equal distances between μ4-O and four metal ions observed in the crystal structure. Based on these results, we suggest that the μ4-atom in Mn4Ca-cluster of PSII is unlikely to be a μ4-O, μ4-OH or μ4-OH2 , and its assignment is still an open question.     

新时期高校院所国家科技经费管理现状及对策

＂十二五＂时期,我国将进入以创新促转型,以转型促发展的新阶段,面对促进经济转型、创新发展模式的艰巨任务,高校院所是我国开展创新科学研究的一支重要力量。近年来,随着高等教育事业的蓬勃发展,高校院所承担的科研项目和筹措的科技经费均呈现大幅度增长,科技经费已成为高校院所重要的资金来源之一。如何提高国家科技经费的使用率、更好发挥国家财政科技经费的引导作用,是我国提高科技创新能力的一个重要任务。为提高国家财政科技经费资金使用效益,确保科研工作健康发展,需高度重视、加强高校院所国家财政科技经费管理及对策研究。     

谈西方礼仪的基本特色

礼仪作为人类物质文明和精神文明进步的产物，其本质是文化，是一种文化的特殊形态，由于各个国家，特别是欧美等西方国家与中国所处的地理环境不同，历史发展状况不同，生产方式和社会制度不同，宗教信仰和传统习俗不同，民族心理品质和思维方式不同，语言文字和价值观念不同，因此形成各具特色的礼仪文化。西方礼仪基本特色有４个方面：一是女士优先，二是尊重隐私，三是表露坦率，四是宗教色彩。     

露天矿边坡移动的动态预报

本文根据监测及数据处理理论,讨论了边坡移动的统计判别方法。利用动态观测系统理论,建立了相应的动态预报模型和动态自适应预报模型。根据所得到的位移场和速度场,讨论了边坡破坏模式的判别方法。