新医改下对药品价格的一点思考

目的:对药品价格调整中出现的问题进行探讨并提出建议。方法:分析廉价实用药品退市、部分药品"改头换面"高价上市等情况出现的原因。结论:进一步完善药品定价机制;加强医疗机构的公益补偿将有利于在新医改下药品价格回归的稳定、合理。     

高校品牌文化的网络传播平台构建与设计研究——以武汉理工大学国际交流网站设计为例

为扩大国际影响力,实现国际化交流,高校可充分利用校园网络平台来传播高校品牌文化。在网络传播平台的设计中,功能设置与视觉设计是交互界面的两大重要因素,需要针对高校国际交流网站用户及该校本身的特点进行设计,从而高效、准确地传播高校的品牌文化。     

基于信号稀疏性的EMT流型辨识

针对电磁层析成像流型识别率低的问题,提出基于信号稀疏性的EMT流型辨识方法.在Maxwell方程组电磁感应原理基础之上,用Comsol有限元仿真软件建立了带有8个电磁线圈的仿真模型.首先建立了几种不同流型的仿真模型并测量其电压值,将测量电压归一化后作为EMT流型辨识的判别依据;然后将其表示为稀疏性组合;最后通过信号稀疏性建立的数学模型求得最优解,从而实现流型归属.实验结果表明:本文方法能对环流、核心流等进行识别,且识别率较高,是一种值得进一步研究和推广的方法.     

四阶龙格库塔法在激光陀螺捷联惯性导航系统中的应用

在激光捷联惯性导航系统中,应用四阶龙格库塔法求解载体速度增量,有效地解决了载体转动过程中三轴陀螺角速度变化对速度的影响,通过与三轴加速度计实测的X,Y,Z方向的加速度叠加,大大减少了导航中速度的累积误差,保证了捷联惯性导航系统在地理坐标系东北天中实时测量载体的三轴运动速度,以及载体航向、横滚、俯仰的快速实时输出,提高了纯惯性导航系统姿态精度和定位精度.动静态寻北、导航实验及捆绑载体测量其姿态跟踪性能的测试结果表明,寻北精度CEP小于0.5密位,横滚、俯仰精度误差小于0.3密位,里程计组合导航精度误差小于1‰.     

NiO nanosheet assembles for supercapacitor electrode materials

In this paper, large scale hierarchically assembled Ni O nanosheets have been favorably fabricated through a facile hydrothermal route. The as-prepared Ni O nanosheet assembles were characterized in detail by various analytical techniques. The results showed these nanosheets present the thickness of about 30 nm and the surface area is 116.9 m~2 g~(-1). These NiO nanosheet assembles were used as the working electrode materials in electrochemical tests, which demonstrated a specific capacitance value of 81.67 Fg ~(-1)at the current density of 0.5 Ag~(-1)and excellent long cycle-life stability with 78.5% of its discharge specific capacitance retention after 3000 cycles at the current density of 0.5 Ag~(-1), revealing the as-synthesized NiO nanosheet assembles might be a promising electrode material for supercapacitor applications.     

Atomic layer deposition on Pd nanocrystals for forming Pd-TiO2 interface toward enhanced CO oxidation

Pd typically exhibits relatively low catalytic activity in CO oxidation, as CO is apt to be adsorbed on Pd to poison the surface for O2 activation. In this Letter, we report that this limitation can be overcome by integrating Pd with TiO2. The TiO2 was coated on Pd nanocubes with a controllable thickness using atomic layer deposition (ALD) method. Given the different work functions of TiO2 and Pd, the electrons in TiO2 semiconductor will flow toward Pd. With the electron density increased on Pd, the adsorption of CO to Pd will be weakened while the oxygen activation can be facilitated. Meanwhile, the interface-confined sites at Pd-TiO2 may further enhance the oxygen activation. As the species adsorption and activation are strongly correlated with electron density, the performance of Pd-TiO2 in CO oxidation turns out to depend on the TiO2 thickness, which determines the number of transferred electrons, within a certain range (<1.8 nm). This work provides a new strategy for enhancing catalytic performance through tailoring charge densities in hybrid catalysts.     

表面增强拉曼散射光谱同时检测4种痕量多环芳烃

合成了植酸保护的纳米金,其具有较强的疏水性和表面增强拉曼散射(SERS)活性.利用小型拉曼光谱仪和分子光谱的指纹信息特征,建立可同时分析水中多种多环芳烃的SERS分析方法.多环芳烃检出限如下:蒽为100μg/L,荧蒽为100μg/L,芘达到10μg/L和苯并芘可达1μg/L.     

热处理对以Al2O3为绝缘层的并五苯薄膜晶体管性能的影响

采用阳极氧化法制备了Al_2O_3绝缘材料,并制备了以Al_2O_3为绝缘层的并五苯薄膜晶体管器件(OTFT)。Al_2O_3绝缘层经过10 min 350℃氢热处理后,OTFT迁移率比未经氢热处理的增大近20倍,且阈值电压降到了-7 V。Al_2O_3膜MIS结构电容—电压(C–V)特性的平带电压平移量数据表明,Al_2O_3膜经过热处理后,并五苯半导体与Al_2O_3绝缘体界面处以及绝缘体内缺陷态密度显著地降低,Al_2O_3绝缘层和并五苯半导体层之间的接触得到改善,这使得经热处理Al_2O_3膜的OTFT器件性能得到显著的改善。     

Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity

A subset of neurons in the brain, known as 'glucose-excited' neurons, depolarize and increase their firing rate in response to increases in extracellular glucose. Similar to insulin secretion by pancreatic beta-cells, glucose excitation of neurons is driven by ATP-mediated closure of ATP-sensitive potassium (K(ATP)) channels. Although beta-cell-like glucose sensing in neurons is well established, its physiological relevance and contribution to disease states such as type 2 diabetes remain unknown. To address these issues, we disrupted glucose sensing in glucose-excited pro-opiomelanocortin (POMC) neurons via transgenic expression of a mutant Kir6.2 subunit (encoded by the Kcnj11 gene) that prevents ATP-mediated closure of K(ATP) channels. Here we show that this genetic manipulation impaired the whole-body response to a systemic glucose load, demonstrating a role for glucose sensing by POMC neurons in the overall physiological control of blood glucose. We also found that glucose sensing by POMC neurons became defective in obese mice on a high-fat diet, suggesting that loss of glucose sensing by neurons has a role in the development of type 2 diabetes. The mechanism for obesity-induced loss of glucose sensing in POMC neurons involves uncoupling protein 2 (UCP2), a mitochondrial protein that impairs glucose-stimulated ATP production. UCP2 negatively regulates glucose sensing in POMC neurons. We found that genetic deletion of Ucp2 prevents obesity-induced loss of glucose sensing, and that acute pharmacological inhibition of UCP2 reverses loss of glucose sensing. We conclude that obesity-induced, UCP2-mediated loss of glucose sensing in glucose-excited neurons might have a pathogenic role in the development of type 2 diabetes.