Optimal design and experiment research of an orthogonal-parallel six-axis force/torque sensor

A novel orthogonal-parallel six-axis force/torque sensor is studied based on a modified Stewart platform architecture,and the optimal design and experiment rese...     

Forecasting stock volatility in the presence of extreme shocks: Short-term and long-term effects

This paper introduces a novel generalized autoregressive conditional heteroskedasticity–mixed data sampling–extreme shocks (GARCH-MIDAS-ES) model for stock volatility to examine whether the importance of extreme shocks changes in different time ranges. Based on different combinations of the short- and long-term effects caused by extreme events, we extend the standard GARCH-MIDAS model to characterize the different responses of the stock market for short- and long-term horizons, separately or in combination. The unique timespan of nearly 100 years of the Dow Jones Industrial Average (DJIA) daily returns allows us to understand the stock market volatility under extreme shocks from a historical perspective. The in-sample empirical results clearly show that the DJIA stock volatility is best fitted to the GARCH-MIDAS-SLES model by including the short- and long-term impacts of extreme shocks for all forecasting horizons. The out-of-sample results and robustness tests emphasize the significance of decomposing the effect of extreme shocks into short- and long-term effects to improve the accuracy of the DJIA volatility forecasts.     

怎样利用Visual Basic制作PowerPoint多媒体课堂时间显示器

针对现代多媒体课堂教学中,PowerPoint全屏放映时无法看到系统时间,影响教学效率这一问题,本文介绍了利用V isual Basic制作PowerPoint多媒体课堂时间显示器的设计思想和方法.     

Blockage of the NLRP3 inflammasome by MCC950 improves anti-tumor immune responses in head and neck squamous cell carcinoma

The NLRP3 inflammasome is a critical innate immune pathway responsible for producing active interleukin (IL)-1β, which is associated with tumor development and immunity. However, the mechanisms regulating the inflammatory microenvironment, tumorigenesis and tumor immunity are unclear. Herein, we show that the NLRP3 inflammasome was over-expressed in human HNSCC tissues and that the IL-1β concentration was increased in the peripheral blood of HNSCC patients. Additionally, elevated NLRP3 inflammasome levels were detected in tumor tissues of Tgfbr1/Pten 2cKO HNSCC mice, and elevated IL-1β levels were detected in the peripheral blood serum, spleen, draining lymph nodes and tumor tissues. Blocking NLRP3 inflammasome activation using MCC950 remarkably reduced IL-1β production in an HNSCC mouse model and reduced the numbers of myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs) and tumor-associated macrophages (TAMs). Moreover, inhibiting NLRP3 inflammasome activation increased the numbers of CD4⁺ and CD8⁺ T cells in HNSCC mice. Notably, the numbers of exhausted PD-1⁺ and Tim3⁺ T cells were significantly reduced. A human HNSCC tissue microarray showed that NLRP3 inflammasome expression was correlated with the expression of CD8 and CD4, the Treg marker Foxp3, the MDSC markers CD11b and CD33, and the TAM markers CD68 and CD163, PD-1 and Tim3. Overall, our results demonstrate that the NLRP3 inflammasome/IL-1β pathway promotes tumorigenesis in HNSCC and inactivation of this pathway delays tumor growth, accompanied by decreased immunosuppressive cell accumulation and an increased number of effector T cells. Thus, inhibition of the tumor microenvironment through the NLRP3 inflammasome/IL-1β pathway may provide a novel approach for HNSCC therapy.     

Seven new species of the genus Pseudostegana (Diptera: Drosophilidae) from South-west China,with DNA barcoding information

Seven new species of the genus Pseudostegana are discovered from South China: P. latiapicula sp. nov., P. nannanae sp. nov., P. bingxueae sp. nov., P. husaensis sp. nov., P. linyongi sp. nov., P. montipagana sp. nov., and P. sigangli sp. nov.; the first two new species belong to the P. latiparma species group, and the rest belong to the P. zonaria species group. The DNA sequences of the mitochondrial cytochrome c oxidase subunit I (COI) gene with BOLD Process ID and GenBank accession numbers are provided for the seven new species and 10 known species from southern China: P. acutifoliolata Li, Gao and Chen, 2010; P. angustifasciata Chen and Wang, 2005, P. bifasciata Chen, Toda and Wang, 2005, P. bilobata Li, Gao and Chen, 2010; P. insularis Li, Gao and Chen, 2010; P. latifasciata Chen, Toda and Wang, 2005, P. minutipalpata; P. nitidifrons Chen and Wang, 2005, P. pallidemaculata Chen and Wang, 2005 and P. silvana. Intra- and interspecific pairwise Kimura’s two-parameter (K2P) distances among these species are summarised. www.zoobank.org/urn:lsid:zoobank.org:pub:C01D7920-61AD-4651-8861-9D76C3CD86F6     

Galanin – 25 years with a multitalented neuropeptide

Galanin, a neuropeptide widely expressed in the central and peripheral nervous systems and in the endocrine system, has been shown to regulate numerous physiological and pathological processes through interactions with three G-protein-coupled receptors, GalR1 through GalR3. Over the past decade, some of the receptor subtype-specific effects have been elucidated through pharmacological studies using subtype selective ligands, as well as through molecular approaches involving knockout animals. In the present review, we summarize the current data which constitute the basis of targeting GalR1, GalR2 and GalR3 for the treatment of various human diseases and pathological conditions, including seizure, Alzheimer's disease, mood disorders, anxiety, alcohol intake in addiction, metabolic diseases, pain and solid tumors.     

基于园林卓越人才培养的观赏植物组织培养课程实践改革

以园林专业卓越人才培养为目标,提出教学过程以应用与创新为导向,更新教学内容体系,探索引入项目式教学形式,调整考核方法.改革后的课程体系侧重学生实践动手能力与创新能力的培养,学生的学习主动性显著提高,在学生中反馈效果好,教学效果显著.     

Genome-wide association studies of 14 agronomic traits in rice landraces

Uncovering the genetic basis of agronomic traits in crop landraces that have adapted to various agro-climatic conditions is important to world food security. Here we have identified ～ 3.6 million SNPs by sequencing 517 rice landraces and constructed a high-density haplotype map of the rice genome using a novel data-imputation method. We performed genome-wide association studies (GWAS) for 14 agronomic traits in the population of Oryza sativa indica subspecies. The loci identified through GWAS explained ～ 36% of the phenotypic variance, on average. The peak signals at six loci were tied closely to previously identified genes. This study provides a fundamental resource for rice genetics research and breeding, and demonstrates that an approach integrating second-generation genome sequencing and GWAS can be used as a powerful complementary strategy to classical biparental cross-mapping for dissecting complex traits in rice.     

月地高速再入返回器热控设计及实现

针对月地高速再入返回器不同阶段大功率散热、小功率保温与高速返回过程中高温隔热之间的突出矛盾,以及狭小、局促空间内设备热量的收集、传输、排散与阻断等技术难题,首次构建一种基于柔性自适应"热开关"的小型再入返回类航天器热控体系,成功研制出一套基于异构式环路热管的一体化柔性、高效热管理系统.在轨飞行数据表明:核心热控产品环路热管控温运行模式下实际传热能力超过65 W,阻断模式下漏热量小于2 W,"热导比"大于30,能够很好地实现"热开关"功能,确保了返回器所有设备的温度水平优于指标要求.