气管滴注纳米二氧化钛对大鼠的亚急性肺毒性实验研究

雄性SD大鼠气管滴注不同剂量的纳米二氧化钛(TiO2),每周2次,连续4周,染毒结束后,检测大鼠血常规、肺组织氧化应激指标和CRP表达,观察肺组织病理学和超微结构改变.结果表明:纳米TiO232 mg/kg组血常规中NEUT计数增加,纳米TiO2引起肺组织中SOD,GSH和CAT含量降低,组织病理学显示随着纳米TiO2染毒剂量增加,肺泡扩张不良、闭塞比例增加,肺内吞噬棕黄色颗粒的巨噬细胞数量增加,肺泡间隔内淋巴细胞和纤维细胞增多;超微结构发现纳米TiO2主要引起Ⅱ型肺泡结构改变.结果显示,在本实验条件下纳米TiO2使大鼠的肺组织受到氧自由基的攻击,肺脏清除氧自由基的能力减弱,并引起肺组织不同程度的病理和超微结构的改变.     

随机需求下的双渠道供应链联合库存模型

针对双渠道的竞合特性增加了供应链系统的需求不确定性,考虑提前期需求波动的情形,构建了2级双渠道供应链独立库存模式和联合库存模式下制造商及零售商的最优基础库存模型和缺货模型,并运用仿真计算方法,通过分析2种库存模式下缺货损失成本、需求波动对双渠道供应链基础库存水平、现货库存水平以及缺货水平等的影响,进一步分析2种库存模式下的成本.结果表明,联合库存模式下的2个渠道各自成本和总成本都要低于独立库存模式下的各成本.因此,双渠道供应链实施联合库存策略可以通过库存共享,协调2个渠道的库存水平,减小缺货风险,从而显著地降低供应链的成本.     

Computational diffusion kinetics and its applications in study and design of rare metallic materials

Computational diffusion kinetics(CDK),with a spirit of and being coupled with the computational thermodynamics(CT,or called as the CALPHAD technique),plays increasingly important role in the alloy design/optimization and microstructure control during the processing of advanced metallic materials.This paper is to highlight recent progress of CDK in research with great focus on novel Ti and Zr alloys,which was largely performed in the authors’group.It ends with one representative example of the applications of CDK,coupled with CT,quantitative phase field,and three-dimensional(3D)statistical calculation,in designing the heattreatment schedule for the dual phase(αβ)Ti–6Al–4V alloys.     

Acid condensation and heat transfer characteristics on H-type fin surface with bleeding dimples and longitudinal vortex generators

Acid condensation rate is an important factor denoting the acid corrosion, and the reduction of the acid condensation can significantly relieve the acid corrosive effect on the wall surface and improve the security of the equipments. In this study, the characteristics of both heat transfer and acid condensation of the finned tube in heat exchanger were numerically studied. In the numerical model, we simulated the acid condensation by considering the vapor-liquid equilibrium effect and multi-component diffusion effect. Based on the H-type finned oval tube, we proposed three novel types of fins to both enhance the heat transfer and reduce the acid condensation. The parametric effects of gas temperature, acid vapor concentration, water vapor concentration, and Reynolds number were investi- gated on different fin structures. The results show that the tube bank with the new structured fins can improve the performance on both heat transfer and acid anticondensation.     

Temporal dynamics in social trust prediction

Inferring unknown social trust relations attracts increasing attention in recent years. However, social trust, as a social concept, is intrinsically dynamic, and exploiting temporal dynamics provides challenges and opportunities for social trust prediction. In this paper, we investigate social trust prediction by exploiting temporal dynamics. In particular, we model the dynamics of user preferences in two principled ways. The first one focuses on temporal weight; the second one targets temporal smoothness. By incorporating these two types of temporal dynamics into traditional matrix factorization based social trust prediction model, two extended social trust prediction models are proposed and the cor- responding algorithms to solve the models are designed too. We conduct experiments on a real-world dataset and the results dem- onstrate the effectiveness of our proposed new models. Further experiments are also conducted to understand the importance of temporal dynamics in social trust prediction.     

CSP生产模式下轧制计划编制模型及算法

针对紧凑式带钢生产(CSP)模式下的轧制计划编制问题,综合考虑设备能力、订单需求和相邻板坯间厚度跳跃,提出一种两阶段问题求解框架。第一阶段以最小化轧制单元数和非计划卷使用量为目标建立整数规划模型,为保证模型的求解效率,从生产实际中提炼出"优先薄板,后补非计划材"的启发式规则进行求解。第二阶段以最小化板坯间平均厚度跳跃为目标来建模,综合考虑非计划卷厚度可变的特性,提出一种多邻域结构的变邻域搜索算法进行求解。通过某CSP生产线的轧制计划编制实例验证了该模型和算法的有效性。     

TMU小黑鼠遗传纯度的生化标记基因检测

本文采用同功酶及异构蛋白醋酸纤维素膜电泳法,对分布在TMU小黑鼠9个染色体上的13个生化基因位点进行检测,以观察其在生化基因位点上的遗传纯度及遗传基因分布。结果表明,TMU小黑鼠在检测位点上的等位基因全部为纯合子。进而从生化标记基因的遗传纯度方面证实该品系动物已达到近交系要求。     

晋南洼槽石油地质基本特征及勘探潜力分析

晋南洼槽是一个典型的中、新生界单断箕状洼槽,洼槽内发育三套良好烃源岩和六套生储盖组合。多期的构造运动,为形成多种类型的油气藏创造了条件。经多年勘探已发现新生古储、傍生侧储、自生自储和下生上储等油气藏类型,并在潜山及下第三系沙河街组二段及三段地层中获得了工业油气流,展示了该洼槽的勘探前景。     

由储层矿物在碱性驱替剂中的化学行为到砂岩储层次生孔隙的形成

本文在对储层矿物、岩石在碱性驱替剂中的化学行为系统研究进行概括的基础上提出了碱性成岩环境有助于砂岩储层次生孔隙发育这一全新的观点,并提出了单旋回成岩环境体系中的“酸-碱链式反应”模型。最后通过岩石矿物组成分析和文献调查证实了碱性成岩环境确实存在。显然,这种观点的应用会对油田油气勘探产生积极的影响。     

背负式弥雾喷粉机的研制

<正>研制性能指标先进的背负式弥雾喷粉机必须总体设计合理、各部件设计能满足机具技术参数的要求,而机具的减振、降噪必须对其振动、噪声频谱进行分析,以确定其振动的性质和需要消声的频率范围,继而进行有关设计。此外,还运用价值工程分析方法对其结构设计和设计思想进行论证分析,以求把产品的功能特征指标与成本确定在最优选择的基础上。