A calcium sensor in the sodium channel modulates cardiac excitability.

Sodium channels are principal molecular determinants responsible for myocardial conduction and maintenance of the cardiac rhythm. Calcium ions (Ca2+) have a fundamental role in the coupling of cardiac myocyte excitation and contraction, yet mechanisms whereby intracellular Ca2+ may directly modulate Na channel function have yet to be identified. Here we show that calmodulin (CaM), a ubiquitous Ca2+-sensing protein, binds to the carboxy-terminal 'IQ' domain of the human cardiac Na channel (hH1) in a Ca2+-dependent manner. This binding interaction significantly enhances slow inactivation-a channel-gating process linked to life-threatening idiopathic ventricular arrhythmias. Mutations targeted to the IQ domain disrupted CaM binding and eliminated Ca2+/CaM-dependent slow inactivation, whereas the gating effects of Ca2+/CaM were restored by intracellular application of a peptide modelled after the IQ domain. A naturally occurring mutation (A1924T) in the IQ domain altered hH1 function in a manner characteristic of the Brugada arrhythmia syndrome, but at the same time inhibited slow inactivation induced by Ca2+/CaM, yielding a clinically benign (arrhythmia free) phenotype.     

PB在企业管理系统中与多种数据库的连接

分析了使用面向对象数据库软件Power Builder开发煤气公司一表一卡管理系统过程中，对SQL Server和Visual Foxpro两种不同数据库的连接，提出了解决新系统与旧系统的数据兼容问题。     

关于三次图边可重构问题的注记

对δ（Ｇ）≥８的连续三次图Ｇ是边可重构的定理给出了一个简单证明。此外还证明了，当δ（Ｇ）＝７，γ（Ｇ）≤８２以及δ（Ｇ）＝６，γ（Ｇ）≤１７时，连续三次图Ｇ是边可重构的     

确定事件视界的新公式

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Abnormal pattern detected in fragile-X patients by pulsed-field gel electrophoresis.

The fragile-X syndrome is the most frequent inherited form of mental retardation, with an incidence of 1 in 1,500 males. It is characterized by the presence of a fragile site at Xq27.3 induced in vitro by folate deprivation or by inhibitors of deoxynucleotide synthesis. Its mode of inheritance is unusual for an X-linked trait, with incomplete penetrance in both males and females. Some phenotypically normal males transmit the mutation to all their daughters who rarely express any symptoms, but penetrance is high in sons and daughters of these carrier women. Genetic and physical mapping of the Xq27-q28 region has confirmed that the disease locus is located at or very near the fragile site. Hypotheses proposed to account for the abnormalities in the inheritance of the disease include sequence rearrangements by meiotic recombination or a mutation that affects reactivation of an inactive X chromosome during differentiation of female germ cells. To detect such rearrangements, or methylation changes that may reflect a locally inactive X chromosome, we used pulsed-field gel analysis of DNA from fragile-X patients with probes close to the fragile-X locus. The probe Do33 (DXS465) detected abnormal patterns in fragile-X patients, but not in normal controls or in non-expressing male transmitters.     

气体催化裂解法制备高纯碳纳米管的研究

利用有机气体化学裂解技术 ,用二甲苯作碳源 ,二茂铁作催化剂 ,噻吩作助长剂 ,氢气作载气 ,对碳纳米管的制备进行了研究 .研究结果表明 ,二甲苯流量、氢气流量及有机气体裂解温度等工艺参数对碳纳米管的产量及形态有很大的影响 ;在反应温度为 10 0 0～ 110 0℃ ,氢气流量为 15 0mL·min- 1,二甲苯的流量为 0 .12 1mL·min- 1时 ,能获得直径为 4 0～ 10 0nm的碳纳米管 ,碳纳米管的纯度可达 95 %以上 .     

基于RFW102的低功耗无线数字收发电路

利用RFW102无线收发芯片,选择合适的微控制器,设计出工作在2.4GHz的无线数字收发电路.并以AD7416温度测量元件为例,简单介绍了此无线收发电路在无线传感器中的应用.与有线方式比较,具有可靠性高、安装容易、重复使用性和系统维护性好等优点.     

PET-云母复合体系的双重Tg转变

本文用粘弹谱仪、x射线衍射、DSC研究了PET—云母复合物的Tg区域的多重转变等松驰转变行为,探讨了加工、云母填充对PET—云母材料性能影响的分子运动机理。不同热历史(如不同成型条件、热处理等)使聚合物分子形成不同链段运动;处于高温位的Tg(u)其运动单元是受结晶、内应力、填料作用影响的非晶区链段。     

信息技术与学科教学的整合需要研究型教师

信息技术与学科的有效整合需要教师具备整合的基本能力，并成为研究型教师。指出教师要不断更新信息技术知识和技能，利用现代教学设施，依据教学实践开展研究，从而探索出有效的整合模式。     

流线型挤出模曲面构造

根据塑料挤出的特点，在编程实现对型材截面轮廓凸凹性自动判断的基础上，采用射线法与比例间隔法相结合的方法，确定流道入口圆周上型值点的位置．以三次多项式作为流道模腔型曲线的数学模型，依据流线型要求给出的初始、边界条件，得出型曲线的数学方程．构建了挤出模流道的三维参数化曲面模型．有限元分析结果显示，该方法创建的流线型流道模型，其流动稳定性和平顺性都优于直线型流道．