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排序方式: 共有48条查询结果,搜索用时 31 毫秒
31.
Williams RB Cotsapas CJ Cowley MJ Chan E Nott DJ Little PF 《Nature genetics》2006,38(8):855-6; author reply 856-9
32.
Amole C Ashkezari MD Baquero-Ruiz M Bertsche W Bowe PD Butler E Capra A Cesar CL Charlton M Deller A Donnan PH Eriksson S Fajans J Friesen T Fujiwara MC Gill DR Gutierrez A Hangst JS Hardy WN Hayden ME Humphries AJ Isaac CA Jonsell S Kurchaninov L Little A Madsen N McKenna JT Menary S Napoli SC Nolan P Olchanski K Olin A Pusa P Rasmussen CØ Robicheaux F Sarid E Shields CR Silveira DM Stracka S So C Thompson RI van der Werf DP Wurtele JS 《Nature》2012,483(7390):439-443
The hydrogen atom is one of the most important and influential model systems in modern physics. Attempts to understand its spectrum are inextricably linked to the early history and development of quantum mechanics. The hydrogen atom's stature lies in its simplicity and in the accuracy with which its spectrum can be measured and compared to theory. Today its spectrum remains a valuable tool for determining the values of fundamental constants and for challenging the limits of modern physics, including the validity of quantum electrodynamics and--by comparison with measurements on its antimatter counterpart, antihydrogen--the validity of CPT (charge conjugation, parity and time reversal) symmetry. Here we report spectroscopy of a pure antimatter atom, demonstrating resonant quantum transitions in antihydrogen. We have manipulated the internal spin state of antihydrogen atoms so as to induce magnetic resonance transitions between hyperfine levels of the positronic ground state. We used resonant microwave radiation to flip the spin of the positron in antihydrogen atoms that were magnetically trapped in the ALPHA apparatus. The spin flip causes trapped anti-atoms to be ejected from the trap. We look for evidence of resonant interaction by comparing the survival rate of trapped atoms irradiated with microwaves on-resonance to that of atoms subjected to microwaves that are off-resonance. In one variant of the experiment, we detect 23 atoms that survive in 110 trapping attempts with microwaves off-resonance (0.21 per attempt), and only two atoms that survive in 103 attempts with microwaves on-resonance (0.02 per attempt). We also describe the direct detection of the annihilation of antihydrogen atoms ejected by the microwaves. 相似文献
33.
E Hough L K Hansen B Birknes K Jynge S Hansen A Hordvik C Little E Dodson Z Derewenda 《Nature》1989,338(6213):357-360
Both the phosphatidylinositol-hydrolysing and the phosphatidylcholine-hydrolysing phospholipases C have been implicated in the generation of second messengers in mammalian cells. The phosphatidylcholine-hydrolysing phospholipase C (PLC) from Bacillus cereus, a monomeric protein containing 245 amino-acid residues, is similar to some of the corresponding mammalian proteins. This, together with the fact that the bacterial enzyme can mimic the action of mammalian PLC in causing, for example, enhanced prostaglandin biosynthesis, suggests that B. cereus PLC can be used as a model for the hitherto poorly characterized mammalian PLCs. We report here the three-dimensional structure of B. cereus PLC at 1.5 A resolution. The enzyme is an all-helix protein belonging to a novel structural class and contains, at least in the crystalline state, three Zn2+ in the active site. We also present preliminary results from a study at 1.9 A resolution of the complex between PLC and inorganic phosphate (Pi) which indicate that the substrate binds directly to the metal ions. 相似文献
34.
P Little P Curtis C Coutelle J Van den Berg R Dalgleish S Malcolm M Courtney D Westaway R Williamson 《Nature》1978,273(5664):640-643
Human globin cDNA-derived recombinants with plasmid pCR1 have been prepared for use as specific hybridisation probes and for the partial sequencing of alpha-, beta- and gamma-globin genes. 相似文献
35.
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37.
Dads and disomy and disease 总被引:7,自引:0,他引:7
38.
Lamandé SR Yuan Y Gresshoff IL Rowley L Belluoccio D Kaluarachchi K Little CB Botzenhart E Zerres K Amor DJ Cole WG Savarirayan R McIntyre P Bateman JF 《Nature genetics》2011,43(11):1142-1146
Familial digital arthropathy-brachydactyly (FDAB) is a dominantly inherited condition that is characterized by aggressive osteoarthropathy of the fingers and toes and consequent shortening of the middle and distal phalanges. Here we show in three unrelated families that FDAB is caused by mutations encoding p.Gly270Val, p.Arg271Pro and p.Phe273Leu substitutions in the intracellular ankyrin-repeat domain of the cation channel TRPV4. Functional testing of mutant TRPV4 in HEK-293 cells showed that the mutant proteins have poor cell-surface localization. Calcium influx in response to the synthetic TRPV4 agonists GSK1016790A and 4αPDD was significantly reduced, and mutant channels did not respond to hypotonic stress. Others have shown that gain-of-function TRPV4 mutations cause skeletal dysplasias and peripheral neuropathies. Our data indicate that TRPV4 mutations that reduce channel activity cause a third phenotype, inherited osteoarthropathy, and show the importance of TRPV4 activity in articular cartilage homeostasis. Our data raise the possibility that TRPV4 may also have a role in age- or injury-related osteoarthritis. 相似文献
39.
Suowen Xu Sayoko Ogura Jiawei Chen Peter J. Little Joel Moss Peiqing Liu 《Cellular and molecular life sciences : CMLS》2013,70(16):2859-2872
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1, also known as OLR-1), is a class E scavenger receptor that mediates the uptake of oxLDL by vascular cells. LOX-1 is involved in endothelial dysfunction, monocyte adhesion, the proliferation, migration, and apoptosis of smooth muscle cells, foam cell formation, platelet activation, as well as plaque instability; all of these events are critical in the pathogenesis of atherosclerosis. These LOX-1-dependent biological processes contribute to plaque instability and the ultimate clinical sequelae of plaque rupture and life-threatening tissue ischemia. Administration of anti-LOX-1 antibodies inhibits atherosclerosis by decreasing these cellular events. Over the past decade, multiple drugs including naturally occurring antioxidants, statins, antiinflammatory agents, antihypertensive and antihyperglycemic drugs have been demonstrated to inhibit vascular LOX-1 expression and activity. Therefore, LOX-1 represents an attractive therapeutic target for the treatment of human atherosclerotic diseases. This review aims to integrate the current understanding of LOX-1 signaling, regulation of LOX-1 by vasculoprotective drugs, and the importance of LOX-1 in the pathogenesis of atherosclerosis. 相似文献
40.
Nadezhda Tikhmyanova Joy L. Little Erica A. Golemis 《Cellular and molecular life sciences : CMLS》2010,67(7):1025-1048
Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-L, EFS/SIN and CASS4/HEPL) are integral
players in normal and pathological cell biology. CAS proteins act as scaffolds to regulate protein complexes controlling migration
and chemotaxis, apoptosis, cell cycle, and differentiation, and have more recently been linked to a role in progenitor cell
function. Reflecting these complex functions, over-expression of CAS proteins has now been strongly linked to poor prognosis
and increased metastasis in cancer, as well as resistance to first-line chemotherapeutics in multiple tumor types including
breast and lung cancers, glioblastoma, and melanoma. Further, CAS proteins have also been linked to additional pathological
conditions including inflammatory disorders, Alzheimer’s and Parkinson’s disease, as well as developmental defects. This review
will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights
into CAS protein function that have emerged in the past decade. 相似文献