一种基于随机进程代数的软件性能预测方法

性能是软件系统的内在属性之一,主要取决于体系结构选择和软件设计.基于模型的性能预测方法可以在软件开发完毕前得到性能需求满足情况的评价,也可帮助系统进行性能规划和调优.使用随机进程代数PEPA对J2EE应用交互过程进行了建模,该模型描绘了远程调用过程和容器处理过程的细节,能有效反映分布式应用中影响性能的主要因素.基于PEPA模型提出了一种面向COTS系统的性能预测方法,并可用于指导改进系统的响应性和可伸缩性.通过一个J2EE实例验证了方法的有效性.     

Volterra series based predistortion for broadband RF power amplifiers with memory effects

RF power amplifiers(PAs)are usually considered as memoryless devices in most existing predistortion techniques.However,in broadband communication systems,such as WCDMA,the PA memory effects are significant,and memoryless predistortion cannot linearize the PAs effectively.After analyzing the PA memory effects,a novel predistortion method based on the simplified Volterra series is proposed to linearize broadband RF PAs with memory effects.The indirect learning architecture is adopted to design the predistortion scheme and the recursive least squares algorithm with forgetting factor is applied to identify the parameters of the predistorter.Simulation results show that the proposed predistortion method can compensate the nonlinear distortion and memory effects of broadband RF PAs effectively.     

Male-pattern baldness susceptibility locus at 20p11

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).     

轿车市场短期需求的多层次灰色预测方法

本文提出一个新的实用多层次灰色预测方法,并用此方法预测了中国轿车产品短期市场需求     

航空电子综合化数据传输网络建模方法研究

采用Petri网理论对航空电子综合化数据传输网络系统的建模方法进行研究。通过对研究对象的基本假设、研究对象与Petri网理论之间的关系,给出了航空电子综合化数据传输网络系统的Petri网模型     

Epigenetic remodeling in colorectal cancer results in coordinate gene suppression across an entire chromosome band

We report a new mechanism in carcinogenesis involving coordinate long-range epigenetic gene silencing. Epigenetic silencing in cancer has always been envisaged as a local event silencing discrete genes. However, in this study of silencing in colorectal cancer, we found common repression of the entire 4-Mb band of chromosome 2q.14.2, associated with global methylation of histone H3 Lys9. DNA hypermethylation within the repressed genomic neighborhood was localized to three separate enriched CpG island 'suburbs', with the largest hypermethylated suburb spanning 1 Mb. These data change our understanding of epigenetic gene silencing in cancer cells: namely, epigenetic silencing can span large regions of the chromosome, and both DNA-methylated and neighboring unmethylated genes can be coordinately suppressed by global changes in histone modification. We propose that loss of gene expression can occur through long-range epigenetic silencing, with similar implications as loss of heterozygosity in cancer.     

Differentiated cells are more efficient than adult stem cells for cloning by somatic cell nuclear transfer

Since the creation of Dolly via somatic cell nuclear transfer (SCNT), more than a dozen species of mammals have been cloned using this technology. One hypothesis for the limited success of cloning via SCNT (1%-5%) is that the clones are likely to be derived from adult stem cells. Support for this hypothesis comes from the findings that the reproductive cloning efficiency for embryonic stem cells is five to ten times higher than that for somatic cells as donors and that cloned pups cannot be produced directly from cloned embryos derived from differentiated B and T cells or neuronal cells. The question remains as to whether SCNT-derived animal clones can be derived from truly differentiated somatic cells. We tested this hypothesis with mouse hematopoietic cells at different differentiation stages: hematopoietic stem cells, progenitor cells and granulocytes. We found that cloning efficiency increases over the differentiation hierarchy, and terminally differentiated postmitotic granulocytes yield cloned pups with the greatest cloning efficiency.     

有约束多目标系统的模糊匈牙利决策及其应用

首先将指标值矩阵转化为模糊关系合成矩阵,再将模糊关系合成矩阵与解决指派问题的匈牙利方法结合起来,提出了有约束多目标系统的一种新决策方法——模糊匈牙利法,并建立其模型,该模型可用著名的匈牙利算法来求解。最后应用该法于文献［1～3］中的实例,通过比较,方法简便,效果很好     

人手柔性触觉感知特性

提出了一种新颖的基于弹性梁有效变形长度控制的柔性触觉感知再现方法,并研制了柔性触觉感知装置.通过在该柔性触觉装置上进行实验,对人手的柔性触觉感知特性进行了研究,得出一些结论.刚度越大,分辨率越低,随着刚度的增大,相比较的2个物体间需具有更大的刚度差异才能够分辨.当人们触摸物体时,习惯的次数为2～6次,按压频率主要分布在0.3～1.3 Hz.实验点的刚度越大越难记忆.连续感知的正确率要明显高于不连续感知的正确率.本实验方法简单有效,得出的实验结论不仅可用来改进触觉再现装置的设计,而且为触觉再现技术的研究提供了生理学依据.     

A Novel Cross-Project Software Defect Prediction Algorithm Based on Transfer Learning

Software Defect Prediction(SDP) technology is an effective tool for improving software system quality that has attracted much attention in recent years. However, the prediction of cross-project data remains a challenge for the traditional SDP method due to the different distributions of the training and testing datasets. Another major difficulty is the class imbalance issue that must be addressed in Cross-Project Defect Prediction(CPDP). In this work,we propose a transfer-leaning algorithm(TSboo...