A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms

The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much attention.An approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be found.Here,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal sources.EVALLERTM,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as allergens.The biomedical journals listed in Highwire(http://highwire.stanford.edu/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human health.The EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in GMOs.The analysis pathway that we have developed can help guide the selection of genes to be used in genetic modification.The pathway also provides a paradigm for allergenicity analysis of transgene candidates.     

一种曲线形态的描述与识别方法及其应用

为准确描述与识别时间序列曲线形态,根据曲线段类型定义了5个语素和1个通配符,进而定义语素向量及通配符向量,使得对曲线的描述具有层次性.据此将任意时间序列曲线转变为对应的二维表,二维表第二列组成的字符串能够进行初级的模板匹配,二维表各行所代表的向量增强了语素关系运算的能力,可实现较深入的模式识别.在经典回溯法的启发下设计了一种属性约束下的带通配符字符串匹配算法,并以基于感应线圈信号曲线的车型分类为例,验证了所提出的方法的有效性和合理性.     

基于GIS的区域人口统计数据空间化——以重庆都市区为例 (三峡地区资源环境生态研究)

人口分布空间化是解决统计数据与自然要素数据融合分析的有效途径。本文基于2009年重庆市的人口统计数据,以居民点为指示因子,使用GIS空间分析与统计学分析方法分析居民点分布与影响因子之间的相关性,相关性分别为-0.608、-0.902、0.94、0.994、0.952、0.995、0.957。利用居民点缓冲区的概念,用因子分析法得到海拔高度、土地利用、道路交通及河流水系4个因子对人口分布的影响权重,分别为0.726 75、0.000 6、0.026 7及0.248 0,然后通过数据融合实现研究区人口统计数据的空间化。结果表明,通过数据融合产生的人口密度与各区县实际平均人口密度的相关系数大于0.85。最终生成的栅格人口密度数据在一定程度上反映了研究区内部人口分布的空间化。     

路基压实效果及其影响因素探讨

路基作为公路的重要组成部分,是路面的基础,它不仅承受着土体本身的荷载作用,还承受着行车荷载的反复作用,是公路的承重主体,所以路基的强度和稳定性是非常重要的.路基的压实工作,是路基施工过程中一个重要工序,是保证路基获得强度与稳定性的根本技术措施之一.文章对影响路基压实效果的几个因素进行了探讨.     

On nearly-controllable subspaces of a class of discrete-time bilinear systems

If a linear time-invariant system is uncontrollable, then the state space can be decomposed as a direct sum of a controllable subspace and an uncontrollable subspace. In this paper, for a class of discrete-time bilinear systems which are uncontrollable but can be nearly controllable, by studying the nearly-controllable subspaces and defining the near-controllability index, the controllability properties of the systems are fully characterized. Examples are provided to illustrate the conceptions and results of the paper.     

Design of an air-slot mode-gap nanocavity in a two dimensional photonic crystal slab

We present a novel and simple design of an air-slot mode-gap photonic crystal(PC) nanocavity by introducing a linear air slot to the center of a line-defect waveguide in a two dimensional triangular-lattice silicon PC slab.A high quality factor(Q factor) of 8.42*105 and an ultrasmall mode volume of 0.998 cubic wavelength are achieved in an optimized air-slot nanocavity which is a suitable choice for the strong matter-field interaction in free space.The high Q cavities with ultrasmall mode volume are important for applications such as quantum computation and nonlinear optics.     

高层建筑消防浅谈

论述了高层建筑消防特点,指出了高层建筑消防中存在的问题,并提出了相应的解决方法,旨在为高层建筑消防的设计提供指导。     

基于ASP和SQL技术的特色数据库开发实践

利用流行的动态Web制作语言,结合SQL数据库技术,设计了图书馆自建特色数据库的开发流程,实现了数据库查询、添加、修改、删除、用户分级管理等完备功能,具有一定的实用性。     

数字地图制图中居民地和道路关系处理

为了解决数图转换过程中要素之间的关系,基于国家基础地理信息,根据现有居民地分类情况,总结了数字制图环境下居民地与道路之间的关系,主要包括依比例尺、半依比例尺及不依比例尺居民地和道路之间的关系;结合国家1:250000和1:50000基础地理信息及不同比例尺数据采集成果,详细给出了不同情况下居民地和道路之间关系的处理方法,主要包括调整图层显示顺序、删除重复采集数据及移位等;基于Vc++和Oracle数据库,就国家1:250000和1:50000中居民地和道路之间关系的自动处理进行了实验。实验表明,利用此方法,对同类问题的解决具有一定的参考价值。     

浅谈水库大坝土方填筑施工

文章结合工程实例，分析了水库土坝填筑碾压试验情况；大坝填筑施工工艺与方法；土料填筑要求及坝体填筑质量控制，以供读者参考。