全文获取类型
收费全文 | 98篇 |
免费 | 0篇 |
专业分类
理论与方法论 | 12篇 |
现状及发展 | 12篇 |
研究方法 | 6篇 |
综合类 | 43篇 |
自然研究 | 25篇 |
出版年
2018年 | 1篇 |
2017年 | 1篇 |
2014年 | 1篇 |
2013年 | 1篇 |
2012年 | 5篇 |
2011年 | 35篇 |
2010年 | 1篇 |
2009年 | 1篇 |
2008年 | 4篇 |
2007年 | 2篇 |
2006年 | 8篇 |
2005年 | 4篇 |
2004年 | 4篇 |
2003年 | 4篇 |
2002年 | 8篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1994年 | 2篇 |
1993年 | 1篇 |
1992年 | 1篇 |
1991年 | 1篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 3篇 |
1982年 | 2篇 |
排序方式: 共有98条查询结果,搜索用时 15 毫秒
71.
Physical characteristics, benthic macroinvertebrates, and periphyton assemblages in two adjacent headwater streams in Yellowstone National Park were evaluated five years after the 1988 wildfires. The catchment of one stream was burned by wildfire (burned stream) while the other catchment was unburned (unburned stream). Physical measures revealed channel alteration in the burned stream relative to the unburned stream Periphyton biomass was lower in the burned than the unburned stream (29.2 vs. 50.5 g/m 2 AFDM, respectively), further demonstrating the unstable physical conditions of that system. Kendall's coefficient of concordance (an index of similarity) between diatom assemblages was 0.22, indicating distinct assemblage composition between streams. Navicula permitis Hust. was the most abundant diatom in the burned stream while Hannaea arcus (Ehr.) Patr. was dominant in the unburned stream. Macroinvertebrate taxa richness, density, and biomass were all greater in the unburned stream, although Chironomidae was the most abundant taxon in both streams. Results suggest the removal of terrestrial/riparian vegetation by wildfire can directly influence benthic assemblages by altering the inherent disturbance regime of the physical habitat templet. 相似文献
72.
The Yellowstone caldera, in the western United States, formed approximately 640,000 years ago when an explosive eruption ejected approximately 1,000 km3 of material. It is the youngest of a series of large calderas that formed during sequential cataclysmic eruptions that began approximately 16 million years ago in eastern Oregon and northern Nevada. The Yellowstone caldera was largely buried by rhyolite lava flows during eruptions that occurred from approximately 150,000 to approximately 70,000 years ago. Since the last eruption, Yellowstone has remained restless, with high seismicity, continuing uplift/subsidence episodes with movements of approximately 70 cm historically to several metres since the Pleistocene epoch, and intense hydrothermal activity. Here we present observations of a new mode of surface deformation in Yellowstone, based on radar interferometry observations from the European Space Agency ERS-2 satellite. We infer that the observed pattern of uplift and subsidence results from variations in the movement of molten basalt into and out of the Yellowstone volcanic system. 相似文献
73.
74.
Wiesmann C Katschke KJ Yin J Helmy KY Steffek M Fairbrother WJ McCallum SA Embuscado L DeForge L Hass PE van Lookeren Campagne M 《Nature》2006,444(7116):217-220
The complement system is a key part of the innate immune system, and is required for clearance of pathogens from the bloodstream. After exposure to pathogens, the third component of the complement system, C3, is cleaved to C3b which, after recruitment of factor B, initiates formation of the alternative pathway convertases. CRIg, a complement receptor expressed on macrophages, binds to C3b and iC3b mediating phagocytosis of the particles, but it is unknown how CRIg selectively recognizes proteolytic C3-fragments and whether binding of CRIg to C3b inhibits convertase activation. Here we present the crystal structure of C3b in complex with CRIg and, using CRIg mutants, provide evidence that CRIg acts as an inhibitor of the alternative pathway of complement. The structure shows that activation of C3 induces major structural rearrangements, including a dramatic movement (>80 A) of the thioester-bond-containing domain through which C3b attaches to pathogen surfaces. We show that CRIg is not only a phagocytic receptor, but also a potent inhibitor of the alternative pathway convertases. The structure provides insights into the complex macromolecular structural rearrangements that occur during complement activation and inhibition. Moreover, our structure-function studies relating the structural basis of complement activation and the means by which CRIg inhibits the convertases provide important clues to the development of therapeutics that target complement. 相似文献
75.
Discovery of a magma chamber and faults beneath a Mid-Atlantic Ridge hydrothermal field 总被引:1,自引:0,他引:1
Singh SC Crawford WC Carton H Seher T Combier V Cannat M Pablo Canales J Düsünür D Escartin J Miranda JM 《Nature》2006,442(7106):1029-1032
Crust at slow-spreading ridges is formed by a combination of magmatic and tectonic processes, with magmatic accretion possibly involving short-lived crustal magma chambers. The reflections of seismic waves from crustal magma chambers have been observed beneath intermediate and fast-spreading centres, but it has been difficult to image such magma chambers beneath slow-spreading centres, owing to rough seafloor topography and associated seafloor scattering. In the absence of any images of magma chambers or of subsurface near-axis faults, it has been difficult to characterize the interplay of magmatic and tectonic processes in crustal accretion and hydrothermal circulation at slow-spreading ridges. Here we report the presence of a crustal magma chamber beneath the slow-spreading Lucky Strike segment of the Mid-Atlantic Ridge. The reflection from the top of the magma chamber, centred beneath the Lucky Strike volcano and hydrothermal field, is approximately 3 km beneath the sea floor, 3-4 km wide and extends up to 7 km along-axis. We suggest that this magma chamber provides the heat for the active hydrothermal vent field above it. We also observe axial valley bounding faults that seem to penetrate down to the magma chamber depth as well as a set of inward-dipping faults cutting through the volcanic edifice, suggesting continuous interactions between tectonic and magmatic processes. 相似文献
76.
Wu H Wacker D Mileni M Katritch V Han GW Vardy E Liu W Thompson AA Huang XP Carroll FI Mascarella SW Westkaemper RB Mosier PD Roth BL Cherezov V Stevens RC 《Nature》2012,485(7398):327-332
Opioid receptors mediate the actions of endogenous and exogenous opioids on many physiological processes, including the regulation of pain, respiratory drive, mood, and--in the case of κ-opioid receptor (κ-OR)--dysphoria and psychotomimesis. Here we report the crystal structure of the human κ-OR in complex with the selective antagonist JDTic, arranged in parallel dimers, at 2.9?? resolution. The structure reveals important features of the ligand-binding pocket that contribute to the high affinity and subtype selectivity of JDTic for the human κ-OR. Modelling of other important κ-OR-selective ligands, including the morphinan-derived antagonists norbinaltorphimine and 5'-guanidinonaltrindole, and the diterpene agonist salvinorin A analogue RB-64, reveals both common and distinct features for binding these diverse chemotypes. Analysis of site-directed mutagenesis and ligand structure-activity relationships confirms the interactions observed in the crystal structure, thereby providing a molecular explanation for κ-OR subtype selectivity, and essential insights for the design of compounds with new pharmacological properties targeting the human κ-OR. 相似文献
77.
78.
Observations of the afterglows of gamma-ray bursts (GRBs) have revealed that they lie at cosmological distances, and so correspond to the release of an enormous amount of energy. The nature of the central engine that powers these events and the prompt gamma-ray emission mechanism itself remain enigmatic because, once a relativistic fireball is created, the physics of the afterglow is insensitive to the nature of the progenitor. Here we report the discovery of linear polarization in the prompt gamma-ray emission from GRB021206, which indicates that it is synchrotron emission from relativistic electrons in a strong magnetic field. The polarization is at the theoretical maximum, which requires a uniform, large-scale magnetic field over the gamma-ray emission region. A large-scale magnetic field constrains possible progenitors to those either having or producing organized fields. We suggest that the large magnetic energy densities in the progenitor environment (comparable to the kinetic energy densities of the fireball), combined with the large-scale structure of the field, indicate that magnetic fields drive the GRB explosion. 相似文献
79.
Natural Caenorhabditis elegans isolates exhibit either social or solitary feeding on bacteria. We show here that social feeding is induced by nociceptive neurons that detect adverse or stressful conditions. Ablation of the nociceptive neurons ASH and ADL transforms social animals into solitary feeders. Social feeding is probably due to the sensation of noxious chemicals by ASH and ADL neurons; it requires the genes ocr-2 and osm-9, which encode TRP-related transduction channels, and odr-4 and odr-8, which are required to localize sensory chemoreceptors to cilia. Other sensory neurons may suppress social feeding, as social feeding in ocr-2 and odr-4 mutants is restored by mutations in osm-3, a gene required for the development of 26 ciliated sensory neurons. Our data suggest a model for regulation of social feeding by opposing sensory inputs: aversive inputs to nociceptive neurons promote social feeding, whereas antagonistic inputs from neurons that express osm-3 inhibit aggregation. 相似文献
80.