The multifaceted role of periostin in tumorigenesis

Periostin, also called osteoblast-specific factor 2 (OSF-2), is a member of the fasciclin family and a disulfide-linked cell adhesion protein that has been shown to be expressed preferentially in the periosteum and periodontal ligaments, where it acts as a critical regulator of bone and tooth formation and maintenance. Furthermore, periostin plays an important role in cardiac development. Recent clinical evidence has also revealed that periostin is involved in the development of various tumors, such as breast, lung, colon, pancreatic, and ovarian cancers. Periostin interacts with multiple cell-surface receptors, most notably integrins, and signals mainly via the PI3-K/Akt and other pathways to promote cancer cell survival, epithelial–mesenchymal transition (EMT), invasion, and metastasis. In this review, aspects related to the function of periostin in tumorigenesis are summarized.     

有效渗透 找准突破 构建交通特色高职文化育人体系——南京交通职业技术学院文化素质教育谈

文化素质教育作为高等教育一种重要思想和实践,旨在给予学生一个合理的知识结构和能力结构,使学生在人格与学问、理智与情感、身体与心理等各方面得到自由、和谐发展。文章认为强调文化素质教育的重要性,是高职教育内涵发展需要,更是遵循了人的成长、成才根本需要。     

浅议美国违宪审查制度

通过对美国违宪审查制度理论基础的研究与评价,分析我国国情,得出美国违宪审查制度不适合我国国情的结论。     

论《东皇太一》的神性及其艺术风格

<东皇太一>庄严肃穆、雍容富丽、热烈虔敬的艺术风格,极具感染力.这种独特的艺术风格形成的主要原因在于"东皇太一"至尊的神性.首先从祭祀仪式的特点来观照"东皇太一"的神性,然后从"太一"的称呼上来分析其至尊的神性,最后从"东皇"这个称呼以及它与"太一"相结合的角度再进一步来论述这个问题.     

社区心理护理体会

随着社区卫生服务的广泛开展，社区护理工作日益显示出其重要性。在整体护理中，心理护理的作用是十分重要的。现将笔者的社区心理护理中的体会总结如下。     

A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms

The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much attention.An approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be found.Here,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal sources.EVALLERTM,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as allergens.The biomedical journals listed in Highwire(http://highwire.stanford.edu/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human health.The EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in GMOs.The analysis pathway that we have developed can help guide the selection of genes to be used in genetic modification.The pathway also provides a paradigm for allergenicity analysis of transgene candidates.     

基于人性技术化与技术人性化的哲学思考

人性技术化和技术人性化是技术与人性关系的两极,也是技术双刃剑特性基于人性的重要表现.对其深层解读和哲学思考,以揭示人性技术化与技术人性化的本质,及其对人性的影响,进而探索由人性技术化的社会现实向技术人性化的理论构想进行转变的路径,对于技术的当代发展有重要意义.     

我国雇主责任保险之立法构想

文章写作宗意从立法角度出发,通过比较借鉴国外的雇主责任保险制度,提出构建雇主责任保险制度及相关配套法律制度的立法建议,以期形成系统机制解决实践中职业伤害赔偿问题,最终建立真正适合我国国情的职业伤害保障机制.     

超声波振动切削装置实用设计研制法概要

本文简要介绍超声波振动切削装置设计研制的基本原则和实用设计研制方法。介绍了振动切削用发生器的性能特点及其保证方法,磁致伸缩换能器、变幅杆和弯曲振动杆等谐振元件的简便准确算法及设计、制造中的一些问题,可拆卸元件连接的基本原则和模式,谐振元、部件和装置的测试和试验方法。指出装置安装调试注意事项。对存在问题和努力方向作了探讨。比较系统地介绍了有关的文献资料。     

线性步进频率编码信号特性的研究

通过理论分析和实际计算,对线性步进频率编码信号(LSDFC)的模糊图、多普勒灵敏性和分辨力等特性进行了研究。结果表明这种信号易于产生和处理,适合用于要求大时宽大带宽的场合。