Multiple newly identified loci associated with prostate cancer susceptibility

Prostate cancer is the most common cancer affecting males in developed countries. It shows consistent evidence of familial aggregation, but the causes of this aggregation are mostly unknown. To identify common alleles associated with prostate cancer risk, we conducted a genome-wide association study (GWAS) using blood DNA samples from 1,854 individuals with clinically detected prostate cancer diagnosed at 相似文献   

连载二洋兰

4.卡特兰属的古塔塔C.guttata（同种异名C.leopoldii） 卡特兰属中蛔古塔塔C.guttata（同种异名C.leopoldii）是卡特兰属中双叶小花系种类，原生于巴西东海岸低地至海拔400米左右的地区。古塔塔guttata的语意是[泪斑]，是因花瓣上有似泪花斑点，而被除数定为种名。南半球的巴西是在1-2月开花，北半球是在7月左右开花。花数可有6-15朵，花虽不很大，植株可高达1.5米，是卡特兰中植株最高的种类。花期长，有芳香味，花的色彩也很多。     

Do prostaglandins mediate the somatostatin preventive effect on gastric lesion?

Summary The inhibition of endogenous prostaglandin synthesis by indomethacin treatment blocks the somatostatin preventive effect on the gastric lesions induced in a stress model and has no preventive effect on an intragastric distension model.     

质环的Jordan理想上的Jordan自同构

证明了下列结果： 设R是一个2-非挠质环； J 是一个Jordan理想， 且是R的子环. 如果φ: R→R是一个自同构， 且对所有的u∈J, 满足: φ(u²)=φ(u)², 则对所有的u,v∈J, 有 φ(uv)=φ(u)φ(v)或φ(uv)=φ(v)φ(u).     

Simulation and uniform design-based automatic generation of risk scenarios

This paper presents a methodology for automatically generating risk scenarios for dynamic reliability applications in which some dynamic characteristics(e.g.,the order,timing and magnitude of events,the value of relevant process parameters and initial conditions) have a significant influence on the evolution of the system.The main idea of the methodology is:(i) making the system model "express itself" through simulation by having the model driven by an elaborated simulation engine;(ii) exploiting uniform design to pick out a small subset of representative design points from the space of relevant dynamic characteristics;(iii) for each selected design point,employing a depth-first systematic exploration strategy to cover all possible scenario branches at each branch point.A highly dynamic example adapted from the literature(a chemical batch reactor) is studied to test the effectiveness of the proposed methodology.     

存在镜面反射时的双目立体匹配

传统的立体匹配方法建立在Lambertian的漫反射模型之上,漫反射模型的立体匹配在一个图像的大多部分是有效的,但是在处理图像中包含镜面反射的部分时结果会产生严重的匹配错误。笔者利用漫反射和镜面反射在灰度和最大色度上的不同,分离出镜面反射的像素,然后采用一种针对镜面反射的匹配测度,在图像中漫反射部分和镜面反射部分都能匹配得到正确的视差。结果证明了方法的有效性。     

When will a Computer Write the Auditor's Report?

Most corporations are required by law to produce annual reports on their financial positions. These financial reports are accompanied by an auditor's report, which is an independent auditor's opinion on the fairness of the financial statements. To formulate their reports, auditors use a “personal-judgement” approach that heavily depends on their experience and expertise. This approach may be (1) ineffective and may lead to (2) different decisions, (3) personal bias, and (4) misleading judgements. These four drawbacks of a human auditor are a source of doubt and hesitation for every corporation. Therefore, the challenging question is: Can a computer do a better job? This paper focuses on the construction and implementation of a knowledge-based system, called the “Auditor's Report EXpert” (AREX), that is capable of formulating the opinion on financial statements, as expressed in the auditor's report. The knowledge used by AREX is acquired from the literature, and from a slate of practicing and academic auditors by means of questionnaires and in-depth interviews. A preliminary validation of AREX indicates that AREX is successful in performing the auditor's report task. Hence, we tentatively conclude that currently a computer program can support an auditor in his/her task. Moreover, in the foreseeable futur's reports that are effective, universal in their decisions, do not show a personal bias, and do not have misleading statements.     

Essential role for the p110delta phosphoinositide 3-kinase in the allergic response

Inflammatory substances released by mast cells induce and maintain the allergic response. Mast cell differentiation and activation are regulated, respectively, by stem cell factor (SCF; also known as Kit ligand) and by allergen in complex with allergen-specific immunoglobulin E (IgE). Activated SCF receptors and high-affinity receptors for IgE (FcvarepsilonRI) engage phosphoinositide 3-kinases (PI(3)Ks) to generate intracellular lipid second messenger signals. Here, we report that genetic or pharmacological inactivation of the p110delta isoform of PI(3)K in mast cells leads to defective SCF-mediated in vitro proliferation, adhesion and migration, and to impaired allergen-IgE-induced degranulation and cytokine release. Inactivation of p110delta protects mice against anaphylactic allergic responses. These results identify p110delta as a new target for therapeutic intervention in allergy and mast-cell-related pathologies.