分布式环境下基于属性证书的RBAC模型

基于角色的访问控制(RBAC)将角色概念引入到访问控制中,极大地方便了用户对资源的访问,同时也减轻了系统保存大量用户信息的压力.在分析RBAC模型的基础上,结合RBAC系统的特点以及SPKI/SDSI证书的优越性,提出了一种分布式环境下的基于属性证书的RBAC模型,定义了属性证书的结构以及描述了用户访问资源的工作流程,对模型的特点进行了总结.分析表明,该模型具有简洁的证书格式、支持匿名访问、单点登录等优点.     

无可信中心的(t,k)门限RSA数字签名体制

提出了一种新的不需要可信中心的门限数字签名方案.在k个成员组成的群组中,只有t个或t个以上成员才能够代表群组签名,而少于t个成员则不能代表群组签名.方案基于Boneh等学者的分布式RSA密钥产生协议和Shamir秘密共享方案而构建.签名过程分为四个阶段:系统初始化、生成个体签名、生成群签名以及签名验证.在系统的初始化阶段不需要可信中心的参与,并且个体签名的生成、群签名的生成和验证都可以方便地实现.通过对方案的安全性分析显示,个体签名和群签名都是不可伪造的,并且在整个签名过程中都没有系统秘密信息的泄漏.     

嵌入式系统中USB Host功能的开发

采用自下向上的设计流程,在没有嵌入式操作系统支持的条件下,自主设计和实现了嵌入式USB Host功能．以ISP1362驱动USB海量存储类设备为例,描述了嵌入式USB Host系统的框架结构和底层驱动的设计方法．实验结果表明,遵从海量存储类子协议的USB设备,都能够被系统驱动,而且数据传输速度优于PC机驱动方式．     

The industrial asymmetry of the stock price prediction with investor sentiment: Based on the comparison of predictive effects with SVR

As a representative emerging financial market, the Chinese stock market is more prone to volatility because of investor sentiment. It is reasonable to use efficient predictive methods to analyze the influence of investor sentiment on stock price forecasting. This paper conducts a comparative study about the predictive performance of artificial neural network, support vector regression (SVR) and autoregressive integrated moving average and selects SVR to study the asymmetry effect of investor sentiment on different industry index predictions. After studying the relevant financial indicators, the results divide the Shenwan first-class industries into two types and show that the industries affected by investor sentiment are composed of young companies with high growth and high operative pressure and there are a great number of investment bubbles in those companies.     

A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis

To identify susceptibility loci for ankylosing spondylitis, we performed a two-stage genome-wide association study in Han Chinese. In the discovery stage, we analyzed 1,356,350 autosomal SNPs in 1,837 individuals with ankylosing spondylitis and 4,231 controls; in the validation stage, we analyzed 30 suggestive SNPs in an additional 2,100 affected individuals and 3,496 controls. We identified two new susceptibility loci between EDIL3 and HAPLN1 at 5q14.3 (rs4552569; P = 8.77 × 10(-10)) and within ANO6 at 12q12 (rs17095830; P = 1.63 × 10(-8)). We also confirmed previously reported associations in Europeans within the major histocompatibility complex (MHC) region (top SNP, rs13202464; P < 5 × 10(-324)) and at 2p15 (rs10865331; P = 1.98 × 10(-8)). We show that rs13202464 within the MHC region mainly represents the risk effect of HLA-B*27 variants (including HLA-B*2704, HLA-B*2705 and HLA-B*2715) in Chinese. The two newly discovered loci implicate genes related to bone formation and cartilage development, suggesting their potential involvement in the etiology of ankylosing spondylitis.     

Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis

Atopic disease, including atopic dermatitis (eczema), allergy and asthma, has increased in frequency in recent decades and now affects approximately 20% of the population in the developed world. Twin and family studies have shown that predisposition to atopic disease is highly heritable. Although most genetic studies have focused on immunological mechanisms, a primary epithelial barrier defect has been anticipated. Filaggrin is a key protein that facilitates terminal differentiation of the epidermis and formation of the skin barrier. Here we show that two independent loss-of-function genetic variants (R510X and 2282del4) in the gene encoding filaggrin (FLG) are very strong predisposing factors for atopic dermatitis. These variants are carried by approximately 9% of people of European origin. These variants also show highly significant association with asthma occurring in the context of atopic dermatitis. This work establishes a key role for impaired skin barrier function in the development of atopic disease.     

Interpretation of the architectural design methods

文章结合笔者近年来的工作实践,从建筑设计因素入手,分析和阐述了建筑设计的几种方法,并提出了自己的一些看法.     

Beta-catenin/TCF4 transactivates miR-30e during intestinal cell differentiation

The Wnt/beta-catenin/TCF4 pathway plays critical roles in the maintenance of small intestinal epithelium; however, downstream targets of the beta-catenin/TCF4 complex are not extensively characterized. We identified miR-30e as an immediate target activated by the beta-catenin/TCF4 complex. miR-30e was detected in the peri-nuclear region of the intestinal crypt IEC-6 cells. Bioinformatics analysis revealed clustered beta-catenin/TCF4 binding sites within the miR-30e promoter region. This promoter region was cloned into pGL3-control luciferase reporter vector, with the enhancer region removed. Transfection of pCMV-SPORT6-beta-catenin expression vector dose-dependently increased luciferase activity, and co-transfection of pCMV-SPORT6-TCF4 expression vector further enhanced the promoter activity. Dexamethasone-induced IEC-6 cells differentiation caused a 2.5-fold increase in miR-30e expression, and upon beta-catenin siRNA transfection, miR-30e increased 1.3-fold. Electrophoretic mobility shift assay and chromatin immunoprecipitation assay confirmed the binding between beta-catenin/TCF4 complexes from IEC-6 nuclear extracts and the putative sequences in the miR-30e promoter. These results demonstrate that beta-catenin/TCF4 transactivates miR-30e during intestinal cell differentiation.