Paralysies révélatrices de la leucémie de Gross chez le rat

Summary Inoculation of Wistar CF rats with Gross virus induces in 86% of the animals a leukaemia which is associated, in nearly 50% of the cases, with a paralysis of the hind legs.This paralysis is due to the compression of the spinal cord by leukaemic cell infiltrates which develop in the lumbar area. No neurotropic virus has been found in these animals.     

Mutations in a Sar1 GTPase of COPII vesicles are associated with lipid absorption disorders

Dietary fat is an important source of nutrition. Here we identify eight mutations in SARA2 that are associated with three severe disorders of fat malabsorption. The Sar1 family of proteins initiates the intracellular transport of proteins in COPII (coat protein)-coated vesicles. Our data suggest that chylomicrons, which vastly exceed the size of typical COPII vesicles, are selectively recruited by the COPII machinery for transport through the secretory pathways of the cell.     

Elevation of serum xanthine oxidase following halothane anesthesia in the rat.

Halothan anesthesia was found to be hapatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine oxidase (SXO) level. SXO appeared to be more sensitive marker of liver damage than serum glutamic oxalacetic transaminase. SXO was found to be elevated also following exposure to relative hypoxia.     

Elevation of serum xanthine oxidase activity following halothane anesthesia in man

Summary Halothane, but not methoxyflurane, was found to cause specific hepatocellular damage, the hepatotoxicity being prompt but transient. The hepatotoxicity was demonstrated by the elevation in the serum activity of xanthine oxidase, a highly sensitive marker for acute liver damage.