Elevation of serum xanthine oxidase following halothane anesthesia in the rat

Summary Halothane anesthesia was found to be hepatotoxic in the rat, as demonstrated by a significant elevation of serum xanthine oxidase (SXO) level. SXO appeared to be a more sensitive marker of liver damage than serum, glutamic oxalacetic transaminsa. SXO was found to be elevated also following exposure to relative hypoxia.     

Concerning amino acids in human saliva

Résumé Dans les travaux de divers laboratoires on peut lire que l'acide-amino-butyrique (GABA) existe dans la salive humaine. Nos récents examens chromatographiques ont mis en évidence que cet acide avait été identifié par erreur et qu'il représente en fait l'acide-amino-valérique (DAVA), un constituant de la salive provenant de l'action bacterienne.     

Initial genome sequencing and analysis of multiple myeloma

Multiple myeloma is an incurable malignancy of plasma cells, and its pathogenesis is poorly understood. Here we report the massively parallel sequencing of 38 tumour genomes and their comparison to matched normal DNAs. Several new and unexpected oncogenic mechanisms were suggested by the pattern of somatic mutation across the data set. These include the mutation of genes involved in protein translation (seen in nearly half of the patients), genes involved in histone methylation, and genes involved in blood coagulation. In addition, a broader than anticipated role of NF-κB signalling was indicated by mutations in 11 members of the NF-κB pathway. Of potential immediate clinical relevance, activating mutations of the kinase BRAF were observed in 4% of patients, suggesting the evaluation of BRAF inhibitors in multiple myeloma clinical trials. These results indicate that cancer genome sequencing of large collections of samples will yield new insights into cancer not anticipated by existing knowledge.     

ADVANCES IN DECISION ANALYSIS AND SYSTEMS ENGINEERING FOR MANAGING LARGE-SCALE ENTERPRISES IN A VOLATILE WORLD： INTEGRATING BENEFITS, OPPORTUNITIES, COSTS AND RISKS （BOCR） WITH THE BUSINESS MOTIVATION MODEL （BMM）

1. Introduction Recent advances in Information and Communication Technologies (ICT) have occurred in a number of areas includinginformation quality (Chutimaskul and Wangpipatwong 2004), strategy (Sha, Hung and Lin 2004) organization (Crowne 2004), technological change (Mitchell 2004), and utility1. Introduction Recent advances in Information and Communication Technologies (ICT) have occurred in a number of areas includinginformation quality (Chutimaskul and Wangpipatwong 2004), strateg…     

Physical association between MHC class I molecules and immunogenic peptides

Antigenic peptides are presented to T lymphocytes by major histocompatibility complex (MHC) molecules. The binding of peptides to MHC class II molecules has been demonstrated directly, and is found to correlate with the ability of specific class II alleles to restrict the T-cell response to specific peptides. By comparison, a direct demonstration of a physical association between antigenic peptides and MHC class I molecules has proved difficult. A recent report shows that it is possible, however, and the three-dimensional structure of a class I MHC molecule illustrates the site where such binding must occur. Here we describe a simple assay which measures the binding of radiolabelled MHC class I molecules to peptides bound to a solid phase support. We find that class I molecules bind specifically to peptides known to be antigenic for class I-restricted cytotoxic T lymphocytes. Peptides which are recognized by cytotoxic T lymphocytes bind not only to the restricting MHC class I molecule but also to other class I molecules. Our results suggest that quantitative differences in the peptide/MHC class I interaction may influence the-pattern of MHC restriction observed in vivo.