演变随机响应问题的工程实用数值解法

把微分方程数值积分的 Runge- Kutta方法引入非均匀调制随机激励下的演变随机响应计算问题中来 ,使复杂的演变随机响应问题得到简便的解决 .通过计算实例 ,并同复模态分析方法比较 ,说明了该方法的有效性和精确性 .该方法不需要进行复杂、费时的复特征值运算 ,只需要直接数值积分 ,具有公式简单 ,编程容易 ,计算速度快等优点 ,特别适合于工程实际问题的计算 .     

中央空调冷却水系统pH与腐蚀的关系

简述了产生腐蚀的危害性,说明了在一定的pH范围内可以避免腐蚀,并从极化曲线和腐蚀电位的角度加以论证,同时指出了在调整pH时应注意的其他问题.     

三峡文物考古数字化展示技术及应用研究

通过对当前数字考古技术的分析,结合三峡考古的特点,设计了三峡文物数字化展示的技术应用构思,运用三维建模、三维大地形,虚拟摄影棚等多媒体技术实现三峡文物考古数字化展示;基于这些技术应用的示例,本文对这些技术在数字考古方面的应用作了一些研究,最后提出了一些想法.     

A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia

We report the first identified mutation in the gene encoding human cytochrome c (CYCS). Glycine 41, invariant throughout eukaryotes, is substituted by serine in a family with autosomal dominant thrombocytopenia caused by dysregulated platelet formation. The mutation yields a cytochrome c variant with enhanced apoptotic activity in vitro. Notably, the family has no other phenotypic indication of abnormal apoptosis, implying that cytochrome c activity is not a critical regulator of most physiological apoptosis.     

Credit risk transfer in SME loan guarantee networks

Joint loan guarantee contracts and mutual guarantee contracts among SMEs form the basis of SME guarantee networks. The expansion of these networks increases the fragility of a financial system as a result of the regional and industrial risk contagion embedded within them. By providing a theoretical framework of a loan guarantee network, a method is proposed for calculating the amount of risk spillover caused by loan guarantees taking the perspective of the entire network. In addition, the route of risk contagion in guarantee networks is analyzed, revealing that when default risk shocks occur, risk contagion travels along the nodes not once but for several rounds and that the risk control of one firm cannot prevent these systemic risks. Therefore, a risk control scheme is designed based on the location and importance of firms in the network. Using data from a real guarantee network, we demonstrate that identifying the node locations of firms’ in the guarantee network (including the coritivity and closeness of the firm) can help in understanding risk contagion mechanisms and preventing systemic credit risk before a crisis occurs.     

基于CF-AHP法的风险斜坡识别方法研究

针对地质灾害隐患识别水平还不够高,灾害发生在“台账外”的问题,风险斜坡识别已成为新时代区域地质灾害调查的主要目标。本文基于贵州省最新地质灾害样本数据库,通过加权确定系数法（CF）分析滑坡及崩塌的影响因子的敏感性,划分出4个危险性值域。结合专家经验,各因子影响权重排序依次为人类工程活动、斜坡结构、坡度、地下水特征、坡形、坡高。再利用层次分析法（AHP）获得7项影响因子的权重大小,形成了快速有效的斜坡危险性打分体系。利用历史典型点进行验证与修正并结合新增地质灾害案例,9处典型历史灾害点原始斜坡危险性与灾害的规模及灾情大小呈线性关系,满足斜坡演变趋势,4处典型风险斜坡中滑坡范围线均位于风险范围线内,变形破坏特征与指标敏感性和权重较为一致,判别结果与实际情况基本相符。通过此方法,最终完成了全省88个县域内78622个斜坡单元的风险斜坡识别,共计查出风险斜坡18196处,将其及时纳入管控对象并提出防治建议,最大限度避免突发性地质灾害发生而造成人民生命财产损失。     

CO2/H2S共存条件下集输管道选材的新方法及应用

在CO₂/H₂S共存条件下集输管道中,管道发生腐蚀的可能性急剧增大,因此集输管道的选材至关重要。若选择管材级别较低,则会严重影响管道的正常生产;若管材级别较高,会引起经济成本的浪费。为了使集输管道在CO₂/H₂S共存条件下选材更加合理。在CO₂/H₂S共存腐蚀速率预测模型的基础上,提出了一种新的集输管道选材方法,新方法的步骤为：计算材质的均匀腐蚀速率,腐蚀速率应满足NACE 标准中腐蚀速率的控制值(小于0.076mm/a),结合管道的设计寿命、剩余强度和经济性评价,确定在CO₂/H₂S共存体系下集输管道的材质。以某油田集输管道为示例,根据新方法选择的材质与实验得到的管材结果一致,验证了新方法的准确性。集输管道选材新方法在保证集输管道安全运行的前提下,能够有效降低管材质选择的成本,有利于保证集输管道的安全性和经济性。     

基于OPC XML-DA规范的C/S模型设计

OPC-C0M 紧密依赖.Windows平台,OPC基金会为提高访问OPC的能力提出了OPC-XML-DA规范。运 用群集和硬件冗余技术提出基于OPC-XML-DA规范的C/S实现模型并详细阐述了该模型,对OPC-XML和OPC-CON 两种数据传输规范进行了比较,从而得出,选用此模型在需跨不同平台通信时是高效可行的。 关键词#*+,’*+,$,*-’*+,$5-6’.:;’群集’冗余     

BAP1 loss defines a new class of renal cell carcinoma

The molecular pathogenesis of renal cell carcinoma (RCC) is poorly understood. Whole-genome and exome sequencing followed by innovative tumorgraft analyses (to accurately determine mutant allele ratios) identified several putative two-hit tumor suppressor genes, including BAP1. The BAP1 protein, a nuclear deubiquitinase, is inactivated in 15% of clear cell RCCs. BAP1 cofractionates with and binds to HCF-1 in tumorgrafts. Mutations disrupting the HCF-1 binding motif impair BAP1-mediated suppression of cell proliferation but not deubiquitination of monoubiquitinated histone 2A lysine 119 (H2AK119ub1). BAP1 loss sensitizes RCC cells in vitro to genotoxic stress. Notably, mutations in BAP1 and PBRM1 anticorrelate in tumors (P = 3 × 10(-5)), and combined loss of BAP1 and PBRM1 in a few RCCs was associated with rhabdoid features (q = 0.0007). BAP1 and PBRM1 regulate seemingly different gene expression programs, and BAP1 loss was associated with high tumor grade (q = 0.0005). Our results establish the foundation for an integrated pathological and molecular genetic classification of RCC, paving the way for subtype-specific treatments exploiting genetic vulnerabilities.     

非结构动网格在变后掠翼气动问题中的应用

对非结构动网格生成的弹簧近似方法进行了研究.采用了顶点弹簧方法,分析研究了弹簧倔强系数的取值,同时通过引入挤压倔强系数和边界修正,对标准弹簧近似方法进行了改进.改进后的方法可以大大提高网格变形能力和网格质量.应用此非结构动网格生成方法并通过耦合求解基于ALE(Arbitrary Lagrangian-Eulerian)描述的Euler方程,模拟了作简谐振动的NACA64A010及M6机翼变后掠状态下的跨音速绕流,计算结果与实验结果吻合良好.