Design of a 3 tier smart middleware system for ubiquitous sensor networks

The multiagent negotiation testbed proposed by Collins was modified. It utilizes publish/subscribe system, timerelease cryptography and anonymous communication. The proposed protocol reduces DOS attack and avoids replay data attack by providing ticket token and deal sequence number to the supplier. And it is proved that generating random number to the supplier by market is better than the supplier doing it by him in guaranteeing anonymity. Market publishes an interpolating polynomial for sharing the determination process data. It avoids collusion between a customer and a certain supplier. According to the comparison and analysis with other protocols, the proposed protocol shows good security and better efficiency.     

Crl：CD（SD）IGS BR大鼠繁育体系的维持与进展

遗传标准化的近交系啮齿类动物体系已有较好的描述,由于生物医学研究的国际化,各国的实验动物供应商应对一般常用的非近交系毒理学动物模型和ＳｐｒａｇｕｅＤａｗｌｅｙ及ＨａｎｏｖｅｒＷｉｓｔａｒ大鼠种系等进行全球标准化,本文描述该类繁育体系,即国际生物医学研究机构采用的Ｃｒｌ：ＣＤ（ＳＤ）ＩＧＳＢＲ和Ｃｒｌ：ＷＩ（ＧＬＸ／ＢＲＬ／Ｈａｍ／ＩＧＳ）ＢＲ大鼠的国际遗传学标准体系（ＩＧＳ）。     

Indian hedgehog is a major mediator of progesterone signaling in the mouse uterus

The hedgehog family of morphogens are regulators of cell proliferation, differentiation and cell-cell communication. These morphogens have been shown to have important roles in organogenesis, spermatogenesis, stem cell maintenance and oncogenesis. Indian hedgehog (encoded by Ihh) has been shown to be expressed in the uterine epithelium under the control of the steroid hormone, progesterone. Although in vivo and in vitro studies have shown that progesterone achieves its effects on uterine function through epithelial-stromal cross-talk, molecular mediator(s) for this cellular communication pathway have not been elucidated. Using new experimental approaches that ablate Ihh specifically in Pgr-positive uterine cells of the mouse, we demonstrate that Ihh is an essential mediator of Pgr action in the uterus, and expression of this factor is critical in mediating the communication between the uterine epithelium and stroma required for embryo implantation.     

The NCBI dbGaP database of genotypes and phenotypes

The National Center for Biotechnology Information has created the dbGaP public repository for individual-level phenotype, exposure, genotype and sequence data and the associations between them. dbGaP assigns stable, unique identifiers to studies and subsets of information from those studies, including documents, individual phenotypic variables, tables of trait data, sets of genotype data, computed phenotype-genotype associations, and groups of study subjects who have given similar consents for use of their data.     

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 are associated with systemic lupus erythematosus

TREX1 acts in concert with the SET complex in granzyme A-mediated apoptosis, and mutations in TREX1 cause Aicardi-Goutières syndrome and familial chilblain lupus. Here, we report monoallelic frameshift or missense mutations and one 3' UTR variant of TREX1 present in 9/417 individuals with systemic lupus erythematosus but absent in 1,712 controls (P = 4.1 x 10(-7)). We demonstrate that two mutant TREX1 alleles alter subcellular targeting. Our findings implicate TREX1 in the pathogenesis of SLE.     

氧化的碳化硅与铝镁合金之间的界面反应

通过FE－SEM（filed emission-scanning electron microscopy),TEM(transmission electron microscopy)和X射线衍射研究了高温氧化的SiC颗粒增强含镁铝合金基复合材料的界面反应过程。发现该界面反应首先形成纳米MgO,然后是否继续与铝液反应取决于Mg的含量以及纳米MgO层致密程度。在Mg含量不足以形成致密的纳米MgO层时,SiO2与MgO和铝液继续反应形成MgAl2O4晶体;当Mg的含量足以形成致密的纳米MgO层,则其能良好地保护内层SiC免受铝液的进一步侵蚀。表明MgO和MgAl2O4为高温热稳定界面反应产物。澄清了对于该界面反应过程的模糊认识和推测。这对于复合材料界面反应控制及界面设计具有重要价值。     

Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis

To find new candidate loci predisposing individuals to Kawasaki disease, an acute vasculitis that affects children, we conducted a genome-wide association study in 622 individuals with Kawasaki disease (cases) and 1,107 controls in a Han Chinese population residing in Taiwan, with replication in an independent Han Chinese sample of 261 cases and 550 controls. We report two new loci, one at BLK (encoding B-lymphoid tyrosine kinase) and one at CD40, that are associated with Kawasaki disease at genome-wide significance (P < 5 × 10(-8)). Our findings may lead to a better understanding of the role of immune activation and inflammation in Kawasaki disease pathogenesis.     

Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations

Chronic kidney disease (CKD), impairment of kidney function, is a serious public health problem, and the assessment of genetic factors influencing kidney function has substantial clinical relevance. Here, we report a meta-analysis of genome-wide association studies for kidney function-related traits, including 71,149 east Asian individuals from 18 studies in 11 population-, hospital- or family-based cohorts, conducted as part of the Asian Genetic Epidemiology Network (AGEN). Our meta-analysis identified 17 loci newly associated with kidney function-related traits, including the concentrations of blood urea nitrogen, uric acid and serum creatinine and estimated glomerular filtration rate based on serum creatinine levels (eGFRcrea) (P < 5.0 × 10(-8)). We further examined these loci with in silico replication in individuals of European ancestry from the KidneyGen, CKDGen and GUGC consortia, including a combined total of ～110,347 individuals. We identify pleiotropic associations among these loci with kidney function-related traits and risk of CKD. These findings provide new insights into the genetics of kidney function.