Variation in complement factor 3 is associated with risk of age-related macular degeneration

The association of variants in complement factors H and B with age-related macular degeneration has led to more intense genetic and functional analysis of the complement pathway. We identify a nonsynonymous coding change in complement factor 3 that is strongly associated with risk of age-related macular degeneration in a large case-control sample.     

A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome

Opitz-Kaveggia syndrome (also known as FG syndrome) is an X-linked disorder characterized by mental retardation, relative macrocephaly, hypotonia and constipation. We report here that the original family for whom the condition is named and five other families have a recurrent mutation (2881C>T, leading to R961W) in MED12 (also called TRAP230 or HOPA), a gene located at Xq13 that functions as a thyroid receptor-associated protein in the Mediator complex.     

Effect of ethanol on toxicity and metabolism of amphetamine in the mouse.

Ethanol, 3 g/kg i.p., did not significantly alter the acute toxicity of amphetamine in the mouse. However, the urinary metabolite pattern was changed, suggesting that ethanol suppressed metabolism of the stimulant during the initial 6 h period. After 24 h, the mouse metabolized the same fraction of a given dose of amphetamine, whether it was given as amphetamine alone or amphetamine mixed with 2,3 or 4 g/kg ethanol.     

Adaptive Asymptotic Tracking Control for Stochastic Nonlinear Systems with Unknown Backlash-Like Hysteresis

In this study, an adaptive asymptotic tracking control problem is considered for stochastic nonlinear systems with unknown backlash-like hysteresis. By utilizing backstepping technology and bound estimation approach, an adaptive asymptotic tracking control scheme is designed, where fuzzy systems are applied to approximate unknown function terms, the effect of hysteresis and stochastic disturbances is compensated appropriately. The proposed scheme ensures that the tracking error can asymptoticall...     

基于LDPC频域编码MIMO-OFDM系统自适应调制算法研究

提出了一种基于发射功率、发送比特和误码率均受限时规则和非规则LDPC频域编码MIMO-OFDM系统自适应调制算法.仿真比较了规则、非规则LDPC编码及未编码自适应调制MIMO-OFDM系统性能,比较了LDPC-SISO-OFDM、LDPC-MIMO-OFDM系统子载波数变化对系统BER性能的影响,比较了收发天线数变化对LDPC-MIMO-OFDM系统BER性能的影响.仿真表明自适应调制MIMO-OFDM系统比非自适应调制系统性能有所提高,规则、非规则LDPC编码自适应调制MIMO-OFDM系统比未编码系统性能有很大提高,非规则LDPC编码自适应调制MIMO-OFDM系统比规则码自适应调制系统性能有提高,但在高信噪比时有错误平层.结果证明,适当设计非规则LDPC频域编码自适应调制算法,可以大大改善MIMO-OFDM系统性能.     

基于元胞自动机的车间天车调度仿真模型

为了解决NP难问题的车间天车调度问题,基于元胞自动机方法建立了车间天车调度仿真模型.用工位、天车、物料、作业调度规则描述天车调度系统,将工位作为模型网络的固定节点、天车为移动节点、吊运的物料为运动粒子;根据车间生产的特点设定工位、天车和物料的属性,抽象出该模型的自组织演化机制.以攀钢板坯连铸车间天车调度为对象的仿真实验表明:根据微观动力学局域作用机制和自组织演化思想建立的天车调度仿真模型方法是可行的,能有效模拟车间天车运行情况.     

隐私侵犯经历对网络用户自我披露的影响机制

网络用户的自我披露对以用户生成内容为业务基础的互联网企业具有战略意义.然而,隐私侵犯事件层出不穷.如何鼓励有隐私侵犯经历的用户持续披露个人信息对互联网企业至关重要.采用系统性随机分层抽样,结合代理理论和社会契约理论构建模型,研究了隐私侵犯经历对自我披露的作用机制.结果表明,隐私侵犯经历对自我披露意愿具有直接效应和间接效应:隐私侵犯经历与自我披露意愿之间存在强烈负向关系,并通过影响网络用户对隐私政策、隐私保护技术、行业自律和法律执行的有效性感知影响自我披露意愿.本研究阐明了隐私侵犯经历对自我披露的具体作用机制,为互联网企业鼓励有隐私侵犯经历的用户持续披露个人信息提供可操作性建议.     

FROM MANUFACTURING SCHEDULING TO SUPPLY CHAIN COORDINATION：THE CONTROL OF COMPLEXITY AND UNCERTAINTY

With time-based competition and rapid technology advancements, effective manufacturingscheduling and supply chain coordination are critical to quickly respond to changing marketconditions. These problems, however, are difficult in view of inherent complexity and variousuncertainties involved. Based on a series of results by the authors, decomposition and coordination byusing Lagrangian relaxation is identified in this paper as an effective way to control complexity anduncertainty.A manufacturing scheduling problem is first formulated within the job shop context withuncertain order arrivals, processing times, due dates, and part priorities as a separable optimizationproblem. A solution methodology that combines Lagrangian relaxation, stochastic dynamicprogramming, and heuristics is developed. Method improvements to effectively solve large problemsare also highlighted. To extend manufacturing scheduling within a factory to coordinate autonomicmembers across chains of suppliers, a decentralized supply chai