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排序方式: 共有66条查询结果,搜索用时 31 毫秒
21.
Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma 总被引:1,自引:0,他引:1
Varela I Tarpey P Raine K Huang D Ong CK Stephens P Davies H Jones D Lin ML Teague J Bignell G Butler A Cho J Dalgliesh GL Galappaththige D Greenman C Hardy C Jia M Latimer C Lau KW Marshall J McLaren S Menzies A Mudie L Stebbings L Largaespada DA Wessels LF Richard S Kahnoski RJ Anema J Tuveson DA Perez-Mancera PA Mustonen V Fischer A Adams DJ Rust A Chan-on W Subimerb C Dykema K Furge K Campbell PJ Teh BT Stratton MR Futreal PA 《Nature》2011,469(7331):539-542
22.
23.
提出一种新的求解时间变换系数的方法,充分发挥时间变换的作用,只需较少的谐波项便可求解一般近似法不能求解的问题,改善了某些求解过程的收敛性 相似文献
24.
5 种两栖爬行动物首次在广东省发现 总被引:2,自引:0,他引:2
记述了广东省两栖动物新记录2种:大花角蟾Megophrys giganticus、黑眼睑小树蛙Phylautus gracilipes以及爬行动物新记录3种:半叶趾虎独山亚种Hemiphylodactylus yunnanensis dushangnensis、广西后棱蛇Oligodon guangxinsis、侧条后棱蛇Oligodon Lateralis、半叶践虎属Hemiphylodactylus亦为广东省新记录. 相似文献
25.
Gregori G Ravasio A Murphy CD Schaar K Baird A Bell AR Benuzzi-Mounaix A Bingham R Constantin C Drake RP Edwards M Everson ET Gregory CD Kuramitsu Y Lau W Mithen J Niemann C Park HS Remington BA Reville B Robinson AP Ryutov DD Sakawa Y Yang S Woolsey NC Koenig M Miniati F 《Nature》2012,481(7382):480-483
The standard model for the origin of galactic magnetic fields is through the amplification of seed fields via dynamo or turbulent processes to the level consistent with present observations. Although other mechanisms may also operate, currents from misaligned pressure and temperature gradients (the Biermann battery process) inevitably accompany the formation of galaxies in the absence of a primordial field. Driven by geometrical asymmetries in shocks associated with the collapse of protogalactic structures, the Biermann battery is believed to generate tiny seed fields to a level of about 10(-21)?gauss (refs 7, 8). With the advent of high-power laser systems in the past two decades, a new area of research has opened in which, using simple scaling relations, astrophysical environments can effectively be reproduced in the laboratory. Here we report the results of an experiment that produced seed magnetic fields by the Biermann battery effect. We show that these results can be scaled to the intergalactic medium, where turbulence, acting on timescales of around 700 million years, can amplify the seed fields sufficiently to affect galaxy evolution. 相似文献
26.
Novel mutations target distinct subgroups of medulloblastoma 总被引:1,自引:0,他引:1
Robinson G Parker M Kranenburg TA Lu C Chen X Ding L Phoenix TN Hedlund E Wei L Zhu X Chalhoub N Baker SJ Huether R Kriwacki R Curley N Thiruvenkatam R Wang J Wu G Rusch M Hong X Becksfort J Gupta P Ma J Easton J Vadodaria B Onar-Thomas A Lin T Li S Pounds S Paugh S Zhao D Kawauchi D Roussel MF Finkelstein D Ellison DW Lau CC Bouffet E Hassall T Gururangan S Cohn R Fulton RS Fulton LL Dooling DJ Ochoa K Gajjar A Mardis ER Wilson RK Downing JR Zhang J Gilbertson RJ 《Nature》2012,488(7409):43-48
Medulloblastoma is a malignant childhood brain tumour comprising four discrete subgroups. Here, to identify mutations that drive medulloblastoma, we sequenced the entire genomes of 37 tumours and matched normal blood. One-hundred and thirty-six genes harbouring somatic mutations in this discovery set were sequenced in an additional 56 medulloblastomas. Recurrent mutations were detected in 41 genes not yet implicated in medulloblastoma; several target distinct components of the epigenetic machinery in different disease subgroups, such as regulators of H3K27 and H3K4 trimethylation in subgroups 3 and 4 (for example, KDM6A and ZMYM3), and CTNNB1-associated chromatin re-modellers in WNT-subgroup tumours (for example, SMARCA4 and CREBBP). Modelling of mutations in mouse lower rhombic lip progenitors that generate WNT-subgroup tumours identified genes that maintain this cell lineage (DDX3X), as well as mutated genes that initiate (CDH1) or cooperate (PIK3CA) in tumorigenesis. These data provide important new insights into the pathogenesis of medulloblastoma subgroups and highlight targets for therapeutic development. 相似文献
27.
Fei Z Rodin AS Andreev GO Bao W McLeod AS Wagner M Zhang LM Zhao Z Thiemens M Dominguez G Fogler MM Castro Neto AH Lau CN Keilmann F Basov DN 《Nature》2012,487(7405):82-85
Surface plasmons are collective oscillations of electrons in metals or semiconductors that enable confinement and control of electromagnetic energy at subwavelength scales. Rapid progress in plasmonics has largely relied on advances in device nano-fabrication, whereas less attention has been paid to the tunable properties of plasmonic media. One such medium--graphene--is amenable to convenient tuning of its electronic and optical properties by varying the applied voltage. Here, using infrared nano-imaging, we show that common graphene/SiO(2)/Si back-gated structures support propagating surface plasmons. The wavelength of graphene plasmons is of the order of 200 nanometres at technologically relevant infrared frequencies, and they can propagate several times this distance. We have succeeded in altering both the amplitude and the wavelength of these plasmons by varying the gate voltage. Using plasmon interferometry, we investigated losses in graphene by exploring real-space profiles of plasmon standing waves formed between the tip of our nano-probe and the edges of the samples. Plasmon dissipation quantified through this analysis is linked to the exotic electrodynamics of graphene. Standard plasmonic figures of merit of our tunable graphene devices surpass those of common metal-based structures. 相似文献
28.
Wang Yingchun Li Ju Chen Fei Lenschow Donal Sun Jielun Niyogi Dev Lau Kaihon Jiang Weimei Ding Guoan Wu Dui 《中国科学基金(英文版)》2005,13(1):23-30
An international workshop on urban meteorology: observation and modeling, was jointly held by the Institute of Urban Meteorology (China) and the National Center for Atmospheric Research (US) in Beijing, October, 2004. The workshop was inten
ded to share recent progress in urban meteorological research, discuss issues re
lated to research and development priorities faced by diverse Chinese institutio
ns, and explore collaboration opportunities between Chinese and US research inst
itutions. This article summarizes the major issues discussed at the workshop, in
cluding observation on urban boundary layer, urban landuse modeling, socioecon
omic impacts of weather and climates, and air quality in urban environment. It i
ncludes recommendations for future urban meteorology observational and modeling
research, and potential collaborative opportunities between China and US. 相似文献
29.
A Functional Framework for Integrating eCRM with Workflow Management Based on Customer Value 总被引:2,自引:0,他引:2
Introduction No other inventions in recent years have had such a deep influence on how companies manage their customer relationships and how they do business as the Internet. Use of the Internet has changed customers’ purchase expectations to a totally n… 相似文献
30.
Utilizing Statistical Semantic Similarity Techniques for Ontology Mapping——with Applications to AEC Standard Models 总被引:2,自引:0,他引:2
The objective of this paper is to introduce three semi-automated approaches for ontology mapping using relatedness analysis techniques. In the architecture, engineering, and construction (AEC) industry, there exist a number of ontological standards to describe the semantics of building models. Although the standards share similar scopes of interest, the task of comparing and mapping concepts among standards is challenging due to their differences in terminologies and perspectives. Ontology mapping is therefore necessary to achieve information interoperability, which allows two or more information sources to exchange data and to re-use the data for further purposes. The attribute-based approach, corpus-based approach, and name-based approach presented in this paper adopt the statistical relatedness analysis techniques to discover related concepts from heterogeneous ontologies. A pilot study is conducted on IFC and CIS/2 ontologies to evaluate the approaches. Preliminary results show that the attribute-based approach outperforms the other two approaches in terms of precision and F-measure. 相似文献