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31.
An integrative genomics approach to infer causal associations between gene expression and disease 总被引:2,自引:0,他引:2
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Genetics of gene expression surveyed in maize,mouse and man 总被引:111,自引:0,他引:111
Schadt EE Monks SA Drake TA Lusis AJ Che N Colinayo V Ruff TG Milligan SB Lamb JR Cavet G Linsley PS Mao M Stoughton RB Friend SH 《Nature》2003,422(6929):297-302
33.
Y. Lambœuf G. de Saint Blanquat R. Derache 《Cellular and molecular life sciences : CMLS》1980,36(3):286-288
Summary Alcohol- and aldehyde-dehydrogenasic activities have been measured in different tissues; these activities are modified after chronic alcoholic intoxication and/or withdrawal in digestive tract, spleen, kidney and lung. The results underline the possible relationship between extra-hepatic ethyl-oxidation and withdrawal syndrome.
Ce travail a été réalisé avec l'aide financière de l'INSERM (ATP 75/5/412/49) et de l'IREB. 相似文献
Ce travail a été réalisé avec l'aide financière de l'INSERM (ATP 75/5/412/49) et de l'IREB. 相似文献
34.
Myofibrillar protein degradation after eccentric exercise 总被引:2,自引:0,他引:2
Male rats were run downhill for 90 minutes (nonexhaustive). Following the exercise, muscle protein degradation was increased, as determined by urinary 3-methylhistidine. However, minimal changes were observed in the relative percentage of the minor myofibrillar proteins and in the protease calcium activated factor in the long head of the triceps brachii muscle (eccentrically exercised) following the exercise bout. 相似文献
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Resemblance of actin-binding protein/actin gels to covalently crosslinked networks 总被引:13,自引:0,他引:13
The maintainance of the shape of cells is often due to their surface elasticity, which arises mainly from an actin-rich cytoplasmic cortex. On locomotion, phagocytosis or fission, however, these cells become partially fluid-like. The finding of proteins that can bind to actin and control the assembly of, or crosslink, actin filaments, and of intracellular messages that regulate the activities of some of these actin-binding proteins, indicates that such 'gel-sol' transformations result from the rearrangement of cortical actin-rich networks. Alternatively, on the basis of a study of the mechanical properties of mixtures of actin filaments and an Acanthamoeba actin-binding protein, alpha-actinin, it has been proposed that these transformations can be accounted for by rapid exchange of crosslinks between actin filaments: the cortical network would be solid when the deformation rate is greater than the rate of crosslink exchange, but would deform or 'creep' when deformation is slow enough to permit crosslinker molecules to rearrange. Here we report, however, that mixtures of actin filaments and actin-binding protein (ABP), an actin crosslinking protein of many higher eukaryotes, form gels rheologically equivalent to covalently crosslinked networks. These gels do not creep in response to applied stress on a time scale compatible with most cell-surface movements. These findings support a more complex and controlled mechanism underlying the dynamic mechanical properties of cortical cytoplasm, and can explain why cells do not collapse under the constant shear forces that often exist in tissues. 相似文献
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Isolation from murine sarcoma cells of novel transforming growth factors potentiated by EGF 总被引:16,自引:0,他引:16
A B Roberts M A Anzano L C Lamb J M Smith C A Frolik H Marquardt G J Todaro M B Sporn 《Nature》1982,295(5848):417-419
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Cell cycle oscillation of phosphatase inhibitor-2 in rat fibroblasts coincident with p34cdc2 restriction 总被引:15,自引:0,他引:15
Attention has focused on the regulation of the eucaryotic cell division cycle since the protein kinase p34cdc2 was identified as a key enzyme in mitotic induction. The level of this kinase remains constant throughout the cell cycle but its activity alters, particularly before M phase. Although the factors regulating cdc2 activity are still unknown, there is increasing evidence that it is influenced by p34cdc2 dephosphorylation. Protein phosphatase inhibitor-2 (I2) is a specific inhibitor of phosphatase type-1, which with type-2A is one of the two principal Ser(P) and Thr(P) phosphatases. Here we show that the level of I2, assayed by immunofluorescence staining, activity measurements, western immunoblotting and metabolic labelling, oscillates during the cell cycle in rat fibroblasts, peaking at S phase and mitosis. Moreover, when we inhibited I2 in vivo by microinjection of anti-I2 antibodies in S-phase cells, the pseudo-mitotic cellular response to injected p34cdc2 was restored, indicating that I2 might have a role in the modulation of p34cdc2 activity. 相似文献