A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1

We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.     

西藏拉萨河谷巴嘎雪湿地植被群落组成及其环境因素之间的相关性

文章以拉萨市巴嘎雪湿地作为研究地点,采用趋势对应分析（DCA）和典范对应分析（CCA）对该湿地植被群落结构、分布格局及其环境条件的相关性进行了研究。其结果表明,巴嘎雪湿地34种主要植物隶属18科32属,其中常见的种有芦苇、肉果草、嵩草、杉叶藻、狐尾藻、水毛茛、矮嵩草、荸荠、西藏粉报春和甘肃马先蒿等。DCA分析表明,26个样方分为三个主要组合类型,分别代表不同的生境类型;34个植物物种分为三种主要的群落类型并与CCA排序分析基本一致。CCA排序分析反映了巴嘎雪湿地植被群落结构和分布格局随着环境变化趋势形成不同物种为代表的三个群落,并且CCA分析确定了影响该湿地植被群落结构和分布格局的主要环境因子,即水位变化、电导率和小生境变化（小丘、积水等）等。     

基于神经网络的模糊综合评判在建筑结构可靠性评估中的应用

提出了一种对结构可靠性进行鉴定的新方法,该方法采用了人工智能技术来减少鉴定的主观性.由于对结构可靠性的认识存在一定的模糊性,采用了多级模糊综合评判进行可靠性鉴定.根据现行鉴定规程,将结构系统分为构件、子单元、鉴定单元三个层次.首先,利用训练后的神经网络求出构件对于不同可靠性等级的隶属度,然后通过多级模糊综合评判求得子单元及鉴定单元对于不同可靠性等级的隶属度.同时,对于检测参数的选取也进行了讨论.图2,表2,参8.     

电致变色聚噻吩及其固态电致变色器件的制备

以2,2':5',2″-三噻吩(3T)作为单体,通过电化学聚合制备了聚噻吩,研究了聚噻吩薄膜的电致变色性能.研究发现,在液体电解质中,当施加外加电压时,聚噻吩薄膜的颜色能发生橙黄色和藏青色的可逆变化.利用聚噻吩作为电致变色活性层制备了固态电致变色器件ITO/聚噻吩/凝胶电解质/ITO,在施加外加电压时,固态电致变色器件也能发生橙黄色和藏青色的可逆变化.     

Food niche of Exomalopsis (Exomalopsis) fulvofasciata Smith (Hymenoptera: Apidae) in Brazilian savannah: the importance of oil-producing plant species as pollen sources

Exomalopsis are ground-nesting species, and their food-niche breadth is little known due the difficulty in locating the nests and finding efficient bait plants to attract these bees. Some species of Exomalopsis were recorded as tomato, hot pepper and eggplant pollinators. Information about the food niche could be useful to increase Exomalopsis populations, providing consistent and comparable data for the enrichment of natural and crop areas with adequate plant sources. This study aimed to determine the food niche and the role of pollen size in the diet of E. fulvofasciata. We analysed pollen loads of 28 individuals of E. fulvofasciata collected from bait plants, in two natural areas of the Brazilian savannah. Only five pollen types belonging to the families Malpighiaceae, Solanaceae, Leguminosae, Myrtaceae and Lythraceae were important for this species. This result indicates that E. fulvofasciata is probably a polylectic species. However, we noticed that the Byrsonima used as bait plants contribute significantly for its larval provision, indicating that small pollen grains were more frequently collected.     

Proteolytic control of TGF-β co-receptor activity by BMP-1/tolloid-like proteases revealed by quantitative iTRAQ proteomics

The metalloproteinase BMP-1 (bone morphogenetic protein-1) plays a major role in the control of extracellular matrix (ECM) assembly and growth factor activation. Most of the growth factors activated by BMP-1 are members of the TGF-β superfamily known to regulate multiple biological processes including embryonic development, wound healing, inflammation and tumor progression. In this study, we used an iTRAQ (isobaric tags for relative and absolute quantification)-based quantitative proteomic approach to reveal the release of proteolytic fragments from the cell surface or the ECM by BMP-1. Thirty-eight extracellular proteins were found in significantly higher or lower amounts in the conditioned medium of HT1080 cells overexpressing BMP-1 and thus, could be considered as candidate substrates. Strikingly, three of these new candidates (betaglycan, CD109 and neuropilin-1) were TGF-β co-receptors, also acting as antagonists when released from the cell surface, and were chosen for further substrate validation. Betaglycan and CD109 proved to be directly cleaved by BMP-1 and the corresponding cleavage sites were extensively characterized using a new mass spectrometry approach. Furthermore, we could show that the ability of betaglycan and CD109 to interact with TGF-β was altered after cleavage by BMP-1, leading to increased and prolonged SMAD2 phosphorylation in BMP-1-overexpressing cells. Betaglycan processing was also observed in primary corneal keratocytes, indicating a general and novel mechanism by which BMP-1 directly affects signaling by controlling TGF-β co-receptor activity. The proteomic data have been submitted to ProteomeXchange with the identifier PXD000786 and doi: 10.6019/PXD000786.     

基于管土作用模型的极限滑坡位移预测

滑坡作为典型地质灾害之一,严重威胁埋地管道的安全运行。若能准确预测管道所能承受的极限滑坡位移,则可结合先进的滑坡监测技术对管道失效事故进行有效预判。有鉴于此,首先建立并验证了基于非线性接触的管土作用模型,之后对模型参数及边界条件设置进行了讨论,最后基于形成的模拟方法研究了应力/应变准则下极限滑坡位移预测方法。结果表明：两侧设置无限边界的非线性接触管土作用模型更适用于真实滑坡工况下管道力学响应分析,可实现土体与管道大变形及管土分离的有效模拟,并可用于基于应力及应变准则的极限滑坡位移预测。本文为山区管道的安全设计及滑坡事故的防控提供了有效的技术手段。     

一种高效率光伏逆变器的实验研究

以单相正弦波驱动模块EGS002为核心器件，研究一种采用直流324~408V供电的高效率光伏逆变器。介绍了该光伏逆变系统的结构和单极性脉宽调制原理，对模块电路进行了详细的分析。实验测试表明，设计的光伏逆变器输出220V/50Hz交流电，转换效率大于98%，输出正弦波稳定，总谐波失真较小、工作性能可靠，还具有过压、欠压、过流和过热保护等功能。     

多小区OFDMA系统中低开销的基站协作资源分配算法

基站协作是多小区正交频分多址接入(OFDMA)系统中降低共信道干扰的有效手段。为了降低收集各小区信息所需的开销,提出一种新的基站协作资源分配算法。算法由各基站计算本小区的业务负荷及所有子信道对本小区的价值,并发送至中心节点。根据这两类信息,资源首先由中心节点分配至各小区,再由各基站分配至用户。该算法的开销仅约为现有方法的2/U(U为协作小区的总用户数)。与无基站协作的方法相比,该算法仍可获得30%以上的用户容量或吞吐量增益。结果表明:本算法兼具实用性和有效性,有望应用于新一代移动通信系统。     

青藏高原特有植物分子谱系地理学研究现状

分子谱系地理学是研究物种或近缘物种遗传谱系地理格局和历史成因机制的一种研究方法.通过重建物种进化历史过程可探讨以往地质事件、地形地貌和气候变化对生物物种形成、分化和扩散的影响.文章通过对近几年来青藏高原特有植物分子谱系地理学研究所取得重要成果的介绍,探讨了高原特有植物谱系地理结构,分析和总结了冰期高原植物微型避难所分布格局、居群各分支分化时间和冰期后回迁和扩散模式等.这些研究结果表明,青藏高原不同植物物种具有不同的冰期避难所分布格局和历史扩散特征.