珍稀濒危药材蛇足石杉的研究概况及开发前景

蛇足石杉中有较高含量的石杉碱甲,对治疗老年痴呆症和提高记忆力有显著疗效,备受国内外学者们的关注.系统总结了近年来国内外学者对蛇足石杉的相关研究成果,旨在为蛇足石杉资源保护与可持续利用、开展蛇足石杉繁殖技术的研究,为解决蛇足石杉原料生产的瓶颈提供理论依据.     

乳酸甲氧苄啶合成工艺初探

对乙醇法和水媒法合成乳酸甲氧苄啶的工艺进行了对比试验，并对二者的收率和成本等因素做了具体的分析研究，目的是探索一条最佳合成工艺流程。     

Antimicrobial and antiviral activity of xylosyl-methylthio-adenosine,a naturally occurring analogue of methylthio-adenosine fromDoris verrucosa

Xylosyl-methylthio-adenosine, a naturally occurring analogue of 5′-deoxy-5′-methylthio-adenosine, has been postulated to play a protective role during egg development in the molluscDoris verrucosa. However, in vitro tests showed that this analogue is devoid of activity against fungi, bacteria and viruses.     

Enhancement of virus growth produced by thiols and disulphides

Summary Several thiols and disulphides have been found able both to shorten the latency phase and to increase the growth of several virus strains in cell cultures.This work has been supported by a grant of Consiglio Nazionale delle Ricerche, Roma (Italy).     

Thiopyrimidines: Specific inhibitors of poliovirus induced early cell damages

Riassunto Contrariamente ad altri inibitori specifici dei poliovirus che prevengono RNA-sintesi virale ed effetto citopatologico, ma non hano effetto sui danni precoci che l'infezione induce nel metabolismo cellulare, un derivato tiopirimidinico è anche capace di impedire il blocco precocem virus indotto, delle proteino-sinsteis cellulari.

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This work has been supported by the Consigiio Nazionale delle Ricerche, Rome (Italy).     

Dichloropyrimidines: Specific inhibitors of virus growth

Summary Dichloropyrimidines can be considered as a new group of antiviral substances having a common spectrum of inhibitory action.This work has been supported by a grant of Consiglio Nazionale delle Ricerche, Rome (Italy).     

Low virulence and immunogenicity in mice and in rabbits of variants ofHerpes simplex virus resistant to 5-iodo-2-deoxyuridine

Résumé Par passage en série sur des cellules en culture et en présence de 5-iodo-2-desoxyuridine (IUdR) on a obtenu une souche de virus herpétique résistant à l'IUdR. Cette souche est très peu virulente chez la souris et le lapin, mais est capable de protéger ces animaux contre le virus pathogène d'origine.

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This work has been supported by a Grant of Consiglio Nazionale delle Ricerche, Roma.