Effects of Eco-Friendly Carrier on Low-Temperature Dyeing of Recycled Polyester Knit Fabrics

This work focused on effects of an eco-friendly carrier JYK on thermal properties,dye uptake,color yield(K/S values)and color fastness of recycled polyester kni...     

Investigating the Impact of Capacity Utilization on Carbon Dioxide Emission:Evidence from China's Iron and Steel Industry

In recent years,China's industrialization and urbanization have deepened,and the economy has grown considerably.But at the same time,they have also brought abou...     

机构投资者存在选择性信息优势吗? ——基于意外信息与无形信息的检验

本文检验了基于意外信息与无形信息的机构信息优势理论,利用沪深A股上市公司2014-2018年的季度数据,实证研究发现:对于含有意外信息的股票,机构持股水平低并表现出减持行为,倾向于低不确定性的避险投资;股票无形信息含量多,机构持股水平高并表现出增持行为,倾向于高成长性的价值投资.另一方面,意外信息和无形信息含量越多,股...     

单操作者大鼠腹腔异位心脏移植模型的建立与改良

目的 学习并改良大鼠腹腔异位心脏移植模型的建立过程,降低手术难度,减短学习周期,使模型易建立以供于移植免疫、病理、药理等方面的研究.方法 建立大鼠腹部异位心脏移植模型,归纳总结整个过程中的操作技巧.结果 正式实验30例,存活29例,存活率96.7％.术中刺伤心脏,开放后无法止血死亡1例,供心阻断时间为(24.2±5.0...     

多维度深海鱼类识别算法

针对深海光线分布不均匀导致鱼类识别检测困难的问题,提出了符合视觉认知的多维度深海鱼类识别算法.该方法从时间维度优化传统的高斯混合模型(GMM)初步确定变化区域,从空间维度构建目标特征,完整提取运动目标,从时空关联维度建立深度学习的鱼类识别框架,试验结果表明:本算法可在多种复杂条件下准确提取运动目标,面积交迭度(AOM)...     

“翻转课堂”概念探析

随着信息技术的发展和普及,很多学校出现了新的教学模式和学习方法,“翻转课堂”作为教学模式的重要变革引起了社会各界的广泛关注,但仍有很多教师对“翻转课堂”存在误解。文章旨在探求该教学模式的概念产生过程及其本质,同时对其功能进行分析和反思,从而为现阶段我国的教育信息化进程提供助益。     

Defining G protein-coupled receptor peptide ligand expressomes and signalomes in human and mouse islets

Introduction

Islets synthesise and secrete numerous peptides, some of which are known to be important regulators of islet function and glucose homeostasis. In this study, we quantified mRNAs encoding all peptide ligands of islet G protein-coupled receptors (GPCRs) in isolated human and mouse islets and carried out in vitro islet hormone secretion studies to provide functional confirmation for the species-specific role of peptide YY (PYY) in mouse islets.

Materials and methods

GPCR peptide ligand mRNAs in human and mouse islets were quantified by quantitative real-time PCR relative to the reference genes ACTB, GAPDH, PPIA, TBP and TFRC. The pathways connecting GPCR peptide ligands with their receptors were identified by manual searches in the PubMed, IUPHAR and Ingenuity databases. Distribution of PYY protein in mouse and human islets was determined by immunohistochemistry. Insulin, glucagon and somatostatin secretion from islets was measured by radioimmunoassay.

Results

We have quantified GPCR peptide ligand mRNA expression in human and mouse islets and created specific signalomes mapping the pathways by which islet peptide ligands regulate human and mouse GPCR signalling. We also identified species-specific islet expression of several GPCR ligands. In particular, PYY mRNA levels were ~ 40,000-fold higher in mouse than human islets, suggesting a more important role of locally secreted Pyy in mouse islets. This was confirmed by IHC and functional experiments measuring insulin, glucagon and somatostatin secretion.

Discussion

The detailed human and mouse islet GPCR peptide ligand atlases will allow accurate translation of mouse islet functional studies for the identification of GPCR/peptide signalling pathways relevant for human physiology, which may lead to novel treatment modalities of diabetes and metabolic disease.

     

可逆计算原理与实验进展

计算能耗高和散热问题使传统计算芯片的集成度和运算能力的提升遇到瓶颈.大规模量子计算探索的关键是比特的相干叠加性和可逆性.因此,可逆计算既作为一种可能从根本上解决计算耗能高和散热问题的方案,又作为一种兼容量子计算的方案,近年来在理论上和实验上得到了深入的研究.本文介绍了可逆计算的基本原理,总结了目前基于微机械、传统微电子和超导领域的可逆计算实验研究进展,分析了超导器件实现可逆计算的独特优势,并着重对其中两种器件的工作原理进行了论述.     

Control of a key transition from prostrate to erect growth in rice domestication

The transition from the prostrate growth of ancestral wild rice (O. rufipogon Griff.) to the erect growth of Oryza sativa cultivars was one of the most critical events in rice domestication. This evolutionary step importantly improved plant architecture and increased grain yield. Here we find that prostrate growth of wild rice from Yuanjiang County in China is controlled by a semi-dominant gene, PROG1 (PROSTRATE GROWTH 1), on chromosome 7 that encodes a single Cys(2)-His(2) zinc-finger protein. prog1 variants identified in O. sativa disrupt the prog1 function and inactivate prog1 expression, leading to erect growth, greater grain number and higher grain yield in cultivated rice. Sequence comparison shows that 182 varieties of cultivated rice, including 87 indica and 95 japonica cultivars from 17 countries, carry identical mutations in the prog1 coding region that may have become fixed during rice domestication.     

一种基于核主元分析的非参数控制限算法

实际过程中,监控指标值往往不满足确定的概率分布,给控制限的计算带来了困难,现有的计算方法计算复杂、精度差.根据高维空间良好的分类特性,提出一种基于核主元分析(KPCA)的监控指标控制限计算方法,将监控指标值映射到高维空间,再在高维空间中对其映射数据进行监控,实现了控制限的间接求取,避免了复杂的计算.