固相燃烧法制备MgO-CeO2纳米粉体

以硝酸铈、醋酸镁为原料,并以酒石酸铵作为还原剂和络合剂,固相反应法合成了前驱物,将前驱物燃烧制备了M gO(0.2)-C eO2(0.8)混合氧化物纳米粉体,考察研究了焙烧温度和酒石酸铵及其用量对样品粒径的影响.采用XRD、TEM、SEM等测试手段对样品的物相粒径形貌进行了表征.样品的形貌为蓬松絮状多孔性立体结构,是M gO纳米粒子担载到C eO2超细粒子表面上的混合氧化物纳米粉体.前驱物经600℃焙烧2 h所得样品平均粒径分别为M gO:6 nm、C eO2:10 nm,经700℃焙烧2 h M gO:8 nm、C eO2:12 nm,经800℃焙烧2h M gO:10 nm、C eO2:18 nm左右.实验发现在同一体系中形成混合氧化物时,两者有互相抑制颗粒生长的作用,则可以得到分散性好、粒径小的纳米粉体.     

点支式玻璃建筑单层索网体系的动力特性

点支式玻璃建筑单层索网体系是一种新型的柔性支承结构体系,其受力特性在很大程度上依赖于所施加的预应力。该文对新保利大厦二期幕墙工程的单层索网结构模型的动力特性进行试验研究,提取了索网在分级预应力下的前三阶频率,并与加玻璃后的情况进行了对比分析。试验结果表明,结构的低阶频率与预应力的关系基本为近似线性关系,而高阶的非线性程度更明显,玻璃对结构的刚度有较大提高,试验与有限元计算结果比较吻合。     

Construction and anti-tumor effects of recombinant fowlpox virus expressing Newcastle disease virus hemagglutinin-neuramidinase gene

Hemagglutinin-neuramidinase (HN), a Newcastle disease virus-derived protein, not only mediates receptor recognition but also possesses neuraminidase (NA) activity, the ability to cleave a component of those receptors, N-acetylneuraminic acid (NAcneu, sialic acid). It is known that this protein in mammalian species, including human beings, has interesting anti-neoplastic as well as immune stimulating properties. To explore the use of the HN gene in cancer gene therapy, we constructed a recombi-nant fowlpox virus expressing the HN protein (vFV-HN) and compared the anti-tumor activity of the recombinant virus with that of wild-type fowlpox virus (FPV) in vivo and in vitro. Here we found that although B16 cells were somewhat resistant to the basal cytotoxic effect of wild-type fowlpox virus, infection with vFV-HN caused a pronounced cytotoxic effect and, the survival of tumor-bearing mice immunized with vFV-HN was significantly increased compared with the survival of mice immunized with the FPV alone. Furthermore, the immunization of mice with vFV-HN elicited a B16 tumor-specific cytotoxic T lymphocyte (CTL) response and clonal expansion of both CD4 and CD8 T cell populations in vivo. In addition, T cells from lymph nodes of mice vaccinated with vFV-HN secreted high levels of the Th1 cytokine IL-2 and IFN-γ, indicating that the regression of tumor cells is related to a Th1-type dominant immune response. These results demonstrate that vaccination with vFV-HN may be a potential strategy for cancer gene therapy.     

北京市平原区地下水开采量反演的数值模拟方法

准确获取地下水开采量统计数据是进行水资源管理的基础,但是由于诸多人为因素,北京平原区调查统计得到的开采量数据与实际产生的开采量有出入.本文提出了地下水开采量反演的地下水数值模拟方法.为获取更接近实际的地下水开采量,基于有限元数值模拟软件FEFLOW,建立了北京市平原区(不包括延庆盆地)地下水流数值模型,依据各行政区开采量对平均水位的灵敏度系数,利用2012-2014年111孔地下水监测井的月动态数据,通过拟合模拟水位和实测水位,采用人工试错法对各区的开采量数据进行反演校正.反演后得到北京市平原区2012-2014年总开采量分别为23.16亿、21.77亿和23.44亿m3.反演后各单孔模拟和实测地下水位拟合较好,模型能较为真实地反映北京平原区地下水动态.以顺义区为典型,利用模型分析了区域地下水位与地下水开采量的关系.模拟结果可为北京市分区县地 下水管理考核工作提供决策支持.      

Simulation and experiment of starting transient flow field of the hydrostatic bearing based on dynamic mesh method

A new method is developed to assess and analyze the dynamic performance of hydrostatic bear-ing oil film by using an amulets-layer dynamic mesh technique.It is implemented using C Language to compile the UDF program of a single oil film of the hydrostatic bearing.The effects of key lubrica-tion parameters of the hydrostatic bearing are evaluated and analyzed under various working condi-tions, i.e.under no-load, a load of 40t, a full load of 160t, and the rotation speed of 1r/min, 2r/min, 4r/min, 8r/min, 16r/min, 32r/min.The transient data of oil film bearing capacity under different load and rotation speed are acquired for a total of 18 working conditions during the oil film thickness changing.It allows the effective prediction of dynamic performance of large size hydrostatic bearing.Experiments on hydrostatic bearing oil film have been performed and the results were used to define the boundary conditions for the numerical simulations and validate the developed numerical model.The results showed that the oil film thickness became thinner with the increase of the operat-ing time of the hydrostatic bearing, both the oil film rigidity and the oil cavity pressure increased sig-nificantly, and the increase of the bearing capacity was inversely proportional to the cube of the change of the film thickness.Meanwhile, the effect of the load condition on carrying capacity of large size static bearing was more important than the speed condition.The error between the simula-tion value and the experimental value was 4 .25%.     

玉米芯吸附协同低温等离子体对H2S的去除作用研究

为解决低温等离子体高压放电后产生的副产物排放问题,采用玉米芯吸附协同低温等离子体系统来降解硫化氢恶臭气体。确定了电极放电特性参数,考察NTP中的极间电压、H2S初始浓度和CA协同对H2S降解的影响,并分析H2S降解机理。研究表明,CA协同NTP系统能显著提高H2S去除效率,当采用负极放电,极板间距40mm,极间电压15KV,H2S初始浓度为500ppb,吸附时间60min时,CA协同NTP去除H2S的去除率可达到90%以上。     

格上基于身份的代理环签名方案

基于原像抽样函数和格基代理算法,构造了格上基于身份的无可信中心的代理环签名,方案的安全性是基于格上SIS和ISIS问题的困难性.方案实现了签名者身份的完全匿名性,在标准模型下证明环签名方案满足存在性不可伪造.     

类风湿关节炎全球药物研发状况分析

 类风湿关节炎（RA）是一种自身免疫性疾病,全球患病率约0.24%。RA发病机制复杂,致残率极高,严重影响患者的生活质量,给社会带来沉重的经济负担,对RA的有效治疗成为全球医药行业关注的重点。据艾美仕数据统计,2015年全球医药市场用于治疗RA的药物支出达214亿美元。本报告依据相关文献及Thomson Reuters、IMS Health等数据库信息,对RA全球药物研发市场、治疗药物类别、靶标、专利等药物研发状况进行分析。目前,RA治疗药物类别包括抗炎药、抗风湿药、激素类药物、生物制剂、联合用药、免疫重建等;治疗靶标有肿瘤坏死因子α、环氧化酶类、B-淋巴细胞抗原、白细胞介素类、细胞核转录因子kB、小分子激酶等;近些年,生物技术药物在RA等自身免疫性疾病治疗领域取得了前所未有的成功,未来市场小分子药物及生物仿制药也将会发挥关键作用。     

一种改进的基于粗糙集理论的启发式特征选择算法

在最大支持启发函数的基础上提出了一种新的基于粗糙集的启发函数,称为参数加权平均支持启发函数.该方法的优点是考虑了可能性规则集的整体质量,它所选出的特征在决策类上能形成具有高加权平均支持度的规则,并且能够利用阈值调整下近似的水平.计算实例表明该方法是有效的.