MRT-2 checkpoint protein is required for germline immortality and telomere replication in C. elegans

The germ line is an immortal cell lineage that is passed indefinitely from one generation to the next. To identify the genes that are required for germline immortality, we isolated Caenorhabditis elegans mutants with mortal germ lines--worms that can reproduce for several healthy generations but eventually become sterile. One of these mortal germline (mrt) mutants, mrt-2, exhibits progressive telomere shortening and accumulates end-to-end chromosome fusions in later generations, indicating that the MRT-2 protein is required for telomere replication. In addition, the germ line of mrt-2 is hypersensitive to X-rays and to transposon activity. Therefore, mrt-2 has defects in responding both to damaged DNA and to normal double-strand breaks present at telomeres. mrt-2 encodes a homologue of a checkpoint gene that is required to sense DNA damage in yeast. These results indicate that telomeres may be identified as a type of DNA damage and then repaired by the telomere-replication enzyme telomerase.     

贯通节理岩体等效模型与弹性参数确定

提出了一种研究贯通节理岩体等效弹性参数的近似模型,导出了贯通节岩体基本弹性常数的解析估算公式,在此模型基础上编写了相应的较为通用计算程序,分析了多组节理的存在以及节理的倾角对岩体性能的影响,预测得到的节理岩体弹性矩阵和弹性常数与节理有限元数值方法的结果十分接近,是一种预测贯通节理岩体等效弹性参数的简单而实用的方法。     

The genome sequence of the rice blast fungus Magnaporthe grisea

Magnaporthe grisea is the most destructive pathogen of rice worldwide and the principal model organism for elucidating the molecular basis of fungal disease of plants. Here, we report the draft sequence of the M. grisea genome. Analysis of the gene set provides an insight into the adaptations required by a fungus to cause disease. The genome encodes a large and diverse set of secreted proteins, including those defined by unusual carbohydrate-binding domains. This fungus also possesses an expanded family of G-protein-coupled receptors, several new virulence-associated genes and large suites of enzymes involved in secondary metabolism. Consistent with a role in fungal pathogenesis, the expression of several of these genes is upregulated during the early stages of infection-related development. The M. grisea genome has been subject to invasion and proliferation of active transposable elements, reflecting the clonal nature of this fungus imposed by widespread rice cultivation.     

用于三维封装的多层芯片键合对准技术

采用离心力使硅片直角边与模具凹槽直角边贴紧对准的思想,提出了一种用于三维系统封装的多芯片对准技术.基于该技术原理制作了对准装置,并实现了多芯片一次性对准键合(6层芯片).具体过程包括:加工带方形凹槽的模具;将芯片切割为形状一致的方形,并保证边缘整齐;将芯片置入凹槽并旋转模具,对准后停止旋转并夹紧固定堆叠芯片;将固定后的芯片转移至键合腔内实现键合,试验测试键合后对准误差为4μm.具体分析了影响多层芯片对准精度的因素,并提出了优化方案,论证了离心对准技术的可行性.     

半导体物理

本书是一本教材，系统地介绍了半导体物理的理论知识。为了使学生能更好地理解和应用这些理论和概念，本书还对一些基于半导体的重要系统的原理进行了简单的解释。全书共分10章。第1章半导体简介，介绍了半导体的定义和重要性、半导体理论的基础和一维理想结晶固体的量子态；第2章理想半导体的量子态，重点介绍了三维半导体的量子态；第3章纯半导体的激发态和含杂质半导体的量子态；第4章均相半导体的统计学；第5章半导体中的迁移现象；第6章光效应；     

成本与变化性关系的灰色模型

在变化减少方案理论的基础上,对变化性二因素和制造系统成本的关系进行了研究,运用灰色系统理论,建立了成本与变化性关系的灰色模型;并应用某纺织机械厂浆纱机产品的成本与变化性关系对部分模型进行了验证．     

Preparation of composite tubular grafts for vascular repair via electrospinning

A novel type of composite vascular graft was developed via electrospinning in the present investigation.Collagen and chitosan were blended to form the inner and outer layer.Poly(1-lactide-co-caprolacto...     

大型钢管无溶剂环氧涂层自动涂装技术

介绍了大型钢管无溶剂环氧涂层自动涂装技术的系统组成、工艺流程、质量检验和涂层修补措施。大型钢管无溶剂环氧涂层自动涂装技术采用热固化技术、涂料加热技术,运用双组份喷涂设备喷涂无溶剂环氧涂料,漆膜均匀厚度偏差小,一次成膜厚、固化时间短,提高防腐涂层的整体防腐性能和生产率,降低工人的劳动强度。     

ELNF归约演算

ＥＬＮＦ演算是在ＬＮＦ演算的基础上扩充而成的函数／逻辑归约演算系统，扩充的主要工作包括逻辑变量、谓词名的引进。提出并描述了逻辑函子ＳＯＬＵＴＩＯＮ和ＰＲＯＶＥ及其归约规则．讨论了ＥＬＮＦ演算的基本概念。为表征ＨＯＲＮ子句提供了一种有效方式。     

弘扬国学精粹 提高人文素质--高校非中文专业开设"中国古典文学鉴赏"课的必要性与可行性

从高校非中文专业学生知识结构的现状出发，阐述加强人文素质教育的重要性；“中国古典文学鉴赏”课的课程特点及其在人文素质教育中所起的作用决定了在高校非中文专业学生中开设这门课程的必要性和可行性。