全文获取类型
收费全文 | 20594篇 |
免费 | 202篇 |
国内免费 | 389篇 |
专业分类
系统科学 | 526篇 |
丛书文集 | 445篇 |
教育与普及 | 99篇 |
理论与方法论 | 68篇 |
现状及发展 | 6267篇 |
研究方法 | 784篇 |
综合类 | 12475篇 |
自然研究 | 521篇 |
出版年
2021年 | 177篇 |
2016年 | 171篇 |
2015年 | 225篇 |
2014年 | 341篇 |
2013年 | 459篇 |
2012年 | 656篇 |
2011年 | 1181篇 |
2010年 | 517篇 |
2009年 | 530篇 |
2008年 | 744篇 |
2007年 | 808篇 |
2006年 | 734篇 |
2005年 | 656篇 |
2004年 | 475篇 |
2003年 | 362篇 |
2002年 | 362篇 |
2001年 | 546篇 |
2000年 | 614篇 |
1999年 | 449篇 |
1992年 | 304篇 |
1991年 | 262篇 |
1990年 | 262篇 |
1989年 | 239篇 |
1988年 | 215篇 |
1987年 | 227篇 |
1986年 | 205篇 |
1985年 | 246篇 |
1984年 | 235篇 |
1983年 | 159篇 |
1982年 | 172篇 |
1981年 | 157篇 |
1980年 | 199篇 |
1979年 | 445篇 |
1978年 | 340篇 |
1977年 | 367篇 |
1976年 | 264篇 |
1975年 | 322篇 |
1974年 | 446篇 |
1973年 | 379篇 |
1972年 | 360篇 |
1971年 | 422篇 |
1970年 | 484篇 |
1969年 | 425篇 |
1968年 | 407篇 |
1967年 | 442篇 |
1966年 | 384篇 |
1965年 | 301篇 |
1959年 | 155篇 |
1958年 | 231篇 |
1957年 | 179篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
对于古典概型问题,一般通过排列组合方法计算,但有的时候计算过于复杂。本文通过几个例题来说明选取合适的样本空间可以简便的解决问题,同时还对这两种方法作比较。 相似文献
12.
本文探讨了高校计算机机房如何进行软硬件配置才能适应教学的管理,发挥出计算机这一现代化武器的优势。 相似文献
13.
研究了Al3+离子的固溶对C-S-H表面吸附Na+离子量的影响.实验结果表明,Al3+离子固溶于C-S-H结构中将使C-S-H表面所带的负电量增大,因而也就增大了C-S-H表面对Na+离子的吸附能力. 相似文献
14.
1 Results Pyrimidinones (PMs) are a class of important heterocycles which have been well documented throughout the literature due to their biological importance. They exhibit a wide range of pharmaceutical and therapeutic properties[1].A rapid and efficient one-pot method for the synthesis of 4,6-diarylpyrimidin-2(1H)- ones and related heterocycles is described.The condensation of acetophenone derivatives,aldehydes and urea in the presence of sulfamic acid was employed to synthesize a variety of pyrimid... 相似文献
15.
李南 《江苏技术师范学院学报》2003,9(2):56-60
通过分析校园网建设中存在的诸如师生缺乏参与意识、可用教育资源不足、管理信息不能互通等问题,就如何充分利用校园网提出了建议,认为要注意提高师生信息素养、建设教育资源库和做好管理信息整合工作,以促进信息化校园的建设。 相似文献
16.
17.
吕玉芳 《济源职业技术学院学报》2002,1(1):48-51
中国共产党始终代表中国先进生产力的发展要求的论断,是站在历史唯物主义的角度,揭示出我们党兴旺发达的根本动力. 相似文献
18.
Nuclear localization and signalling activity of phosphoinositidase C beta in Swiss 3T3 cells. 总被引:14,自引:0,他引:14
The hydrolysis of phosphatidylinositol 4,5-bisphosphate (PtdInsP2) is a widespread receptor-coupled signalling system at the plasma membrane of most eukaryotic cells. The existence of an entirely separate nuclear phosphoinositide signalling system is suggested from evidence that purified nuclei synthesize PtdInsP2 and phosphatidylinositol 4-phosphate (PtdInsP) in vitro and that a transient decrease in the mass of these lipids occurs when Swiss 3T3 cells are cultured in the presence of insulin-like growth factor-1 (IGF-1). These IGF-1-dependent changes in inositol lipids coincide with an increase in nuclear diacyglycerol and precede translocation to the nucleus and activation of protein kinase C (refs 5, 6). Circumstantial evidence that links these changes with mitosis comes from the isolation of a 3T3 clone that expresses the type-1 IGF receptor and binds IGF-1 peptide but does not respond mitogenically or show transient mass changes in nuclear inositol lipids. A key question is how IGF-1 initiates the rapid breakdown of PtdInsP and PtdInsP2 in the nucleus. Here we present evidence that nuclei of 3T3 cells contain the beta-isozyme of phosphoinositidase C, whereas the gamma-isozyme is confined to the cytoplasm and that IGF-1 treatment stimulates exclusively the activity of nuclear phosphoinositidase C. 相似文献
19.
To validate procedures of rational drug design, it is important to develop computational methods that predict binding sites between a protein and a ligand molecule. Many small molecules have been tested using such programs, but examination of protein-protein and peptide-protein interactions has been sparse. We were able to test such applications once the structures of both the maltose-binding protein (MBP) and the ligand-binding domain of the aspartate receptor, which binds MBP, became available. Here we predict the binding site of MBP to its receptor using a 'binary docking' technique in which two MBP octapeptide sequences containing mutations that eliminate maltose chemotaxis are independently docked to the receptor. The peptides in the docked solutions superimpose on their original positions in the structure of MBP and allow the formation of an MBP-receptor complex. The consistency of the computational and biological results supports this approach for predicting protein-protein and peptide-protein interactions. 相似文献
20.
Short alanine peptides, containing 16 or 17 residues, appear to form alpha-helices in aqueous solution. But the main spectroscopic analyses used on helical peptides (circular dichroism and nuclear magnetic resonance) cannot distinguish between an alpha-helix (in which the ith residue is hydrogen-bonded to residue i + 4; ref. 9) and the next most common peptide helix, the 3(10)-helix10 (i-->i + 3 hydrogen-bonding). To address this problem we have designed single and doubly spin-labelled analogues of alanine-based peptides in which the nitroxide spin label forms an unbranched side chain extending from the sulphur atom of a cysteine residue. Here we report the circular dichroism, Fourier-transform infrared and electron-spin resonance spectra of these peptides under helix-forming conditions. The infrared absorbance gives an amide I' band with a frequency that is substantially different from that observed for alpha-helices. The electron-spin resonance spectra of doubly labelled helices show that the ranking of distances between side chains, around a single turn (residues 4-8), is inconsistent with an alpha-helical structure. Our experiments suggest that the more likely peptide geometry is a 3(10)-helix. 相似文献