全文获取类型
收费全文 | 172篇 |
免费 | 1篇 |
国内免费 | 4篇 |
专业分类
系统科学 | 9篇 |
丛书文集 | 2篇 |
理论与方法论 | 2篇 |
现状及发展 | 23篇 |
研究方法 | 22篇 |
综合类 | 117篇 |
自然研究 | 2篇 |
出版年
2018年 | 1篇 |
2015年 | 4篇 |
2014年 | 5篇 |
2013年 | 2篇 |
2012年 | 13篇 |
2011年 | 15篇 |
2010年 | 4篇 |
2009年 | 10篇 |
2008年 | 17篇 |
2007年 | 12篇 |
2006年 | 13篇 |
2005年 | 15篇 |
2004年 | 8篇 |
2003年 | 9篇 |
2002年 | 7篇 |
2001年 | 6篇 |
2000年 | 4篇 |
1999年 | 4篇 |
1998年 | 4篇 |
1997年 | 1篇 |
1996年 | 4篇 |
1995年 | 2篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1990年 | 2篇 |
1989年 | 2篇 |
1987年 | 1篇 |
1983年 | 1篇 |
1979年 | 2篇 |
1977年 | 1篇 |
1972年 | 2篇 |
排序方式: 共有177条查询结果,搜索用时 31 毫秒
41.
枫杨、羊蹄水浸液对钉螺肝功能的影响 总被引:9,自引:1,他引:8
用酶学速率法测定并分析了不同浓度枫杨、羊蹄水浸液对钉螺肝脏谷丙转氨酶 (GPT)、谷草转氨酶 (GOT)活力的影响 ,同时比较了两种植物的作用效果及灭螺效果 .结果显示 ,随枫杨叶水浸液浓度的升高 ,GPT、GOT酶活力随之增高 ,0 .1 %、0 .5%浓度 (质量体积分数 )与水对照无明显差异 ,1 .0 %、2 .5%显著高于水对照 .羊蹄处理之钉螺肝GPT和GOT活性随浓度升高到 1 .0 %浓度达到峰值 ,2 .5%开始下降 ;除 0 .1 %与对照无明显差异外 ,其余浓度有明显差异 .两种植物相比 ,羊蹄对两种转氨酶的影响明显大于枫杨 ,灭螺效果也较之好 . 相似文献
42.
Structural view of cadherin-mediated cell-cell adhesion 总被引:1,自引:0,他引:1
Following the multiplication of biochemical, biophysical and structural studies describing cadherin molecules and their interactions,
several ideas have emerged to explain the mechanisms of cadherin-mediated cell adhesion. Although different models were proposed
for cadherin interactions, a consensus has come forth considering lateral dimerization of cadherins as being a central component
of the cell-cell adhesion process. This review summarizes the recent development in structural studies of cadherins.
Received 14 September 1998; received after revision 14 November 1998; accepted 16 November 1998 相似文献
43.
This paper presents a dynamic probabilistic marking algorithm with multiple routing address tags, which allows the victim to traceback the origin of ICMP (Internet Control Message Protocol)-based direct and reflective DoS attacks. The proposed approach makes full use of scalable data space of ICMP packet to achieve multiple information tags. The difference between this proposal and previous proposals lies in two points. First, the number of packets needed by the victim to reconstruct the attack path is greatly reduced because of three key mechanisms: multi-tag, uniform leftover probability, and tag location choice based on the module of accommodated tag numbers within a packet. Second, the true origin of both direct and reflective ICMP-based DoS attacks can be traced. 相似文献
44.
45.
Nusbaum C Mikkelsen TS Zody MC Asakawa S Taudien S Garber M Kodira CD Schueler MG Shimizu A Whittaker CA Chang JL Cuomo CA Dewar K FitzGerald MG Yang X Allen NR Anderson S Asakawa T Blechschmidt K Bloom T Borowsky ML Butler J Cook A Corum B DeArellano K DeCaprio D Dooley KT Dorris L Engels R Glöckner G Hafez N Hagopian DS Hall JL Ishikawa SK Jaffe DB Kamat A Kudoh J Lehmann R Lokitsang T Macdonald P Major JE Matthews CD Mauceli E Menzel U Mihalev AH Minoshima S Murayama Y Naylor JW Nicol R 《Nature》2006,439(7074):331-335
The International Human Genome Sequencing Consortium (IHGSC) recently completed a sequence of the human genome. As part of this project, we have focused on chromosome 8. Although some chromosomes exhibit extreme characteristics in terms of length, gene content, repeat content and fraction segmentally duplicated, chromosome 8 is distinctly typical in character, being very close to the genome median in each of these aspects. This work describes a finished sequence and gene catalogue for the chromosome, which represents just over 5% of the euchromatic human genome. A unique feature of the chromosome is a vast region of approximately 15 megabases on distal 8p that appears to have a strikingly high mutation rate, which has accelerated in the hominids relative to other sequenced mammals. This fast-evolving region contains a number of genes related to innate immunity and the nervous system, including loci that appear to be under positive selection--these include the major defensin (DEF) gene cluster and MCPH1, a gene that may have contributed to the evolution of expanded brain size in the great apes. The data from chromosome 8 should allow a better understanding of both normal and disease biology and genome evolution. 相似文献
46.
Inoue K Khajavi M Ohyama T Hirabayashi S Wilson J Reggin JD Mancias P Butler IJ Wilkinson MF Wegner M Lupski JR 《Nature genetics》2004,36(4):361-369
The molecular mechanisms by which different mutations in the same gene can result in distinct disease phenotypes remain largely unknown. Truncating mutations of SOX10 cause either a complex neurocristopathy designated PCWH or a more restricted phenotype known as Waardenburg-Shah syndrome (WS4; OMIM 277580). Here we report that although all nonsense and frameshift mutations that cause premature termination of translation generate truncated SOX10 proteins with potent dominant-negative activity, the more severe disease phenotype, PCWH, is realized only when the mutant mRNAs escape the nonsense-mediated decay (NMD) pathway. We observe similar results for truncating mutations of MPZ that convey distinct myelinopathies. Our experiments show that triggering NMD and escaping NMD may cause distinct neurological phenotypes. 相似文献
47.
48.
49.
50.
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells 总被引:45,自引:0,他引:45