Tissue survey of mammalian modulator-dependent protein kinases

Summary The levels of modulator-dependent protein kinases and protamine-dependent protein kinase(s) in various tissues of adult mice were compared. Cerebellum contained the highest levels of both modulator-dependent protein kinases and protamine-dependent protein kinase(s), whereas skeletal muscle contained no detectable enzymes. The lung and the ileum were also rich in modulator-dependent protein kinases, while other tissues were poor sources of these enzymes.Acknowledgments. This work was supported by grants (RR-08119-PK project from the National Institutes of Health, USA. and CDP-8004200 from the National Science Foundation, USA.     

Integration of cytogenetic landmarks into the draft sequence of the human genome

We have placed 7,600 cytogenetically defined landmarks on the draft sequence of the human genome to help with the characterization of genes altered by gross chromosomal aberrations that cause human disease. The landmarks are large-insert clones mapped to chromosome bands by fluorescence in situ hybridization. Each clone contains a sequence tag that is positioned on the genomic sequence. This genome-wide set of sequence-anchored clones allows structural and functional analyses of the genome. This resource represents the first comprehensive integration of cytogenetic, radiation hybrid, linkage and sequence maps of the human genome; provides an independent validation of the sequence map and framework for contig order and orientation; surveys the genome for large-scale duplications, which are likely to require special attention during sequence assembly; and allows a stringent assessment of sequence differences between the dark and light bands of chromosomes. It also provides insight into large-scale chromatin structure and the evolution of chromosomes and gene families and will accelerate our understanding of the molecular bases of human disease and cancer.     

高速工业平缝机噪声源的鉴别

采用分部运转法、遮掩运行法、声强测量法和相干分析法四种方法，比较准确地鉴别了高速工业平缝机的噪声源，对该机减振降噪的研究提供了可靠的依据     

Transferrin receptor is necessary for development of erythrocytes and the nervous system

Plasma iron circulates bound to transferrin (Trf), which solubilizes the ferric ion and attenuates its reactivity. Diferric Trf interacts with cell-surface Trf receptor (Trfr) to undergo receptor-mediated endocytosis into specialized endosomes. Endosomal acidification leads to iron release, and iron is transported out of the endosome through the activity of divalent metal transporter 1 (DMT1, formerly Nramp2), a transmembrane iron transporter that functions only at low pH. Trf and Trfr then return to the cell surface for reuse, completing a highly efficient cycle. Although the Trf cycle is assumed to be the general mechanism for cellular iron uptake, this has not been validated experimentally. Mice with hypotransferrinaemia (hpx) have little or no plasma Trf. They have severe anaemia, indicating that the Trf cycle is essential for iron uptake by erythroid cells. Other hpx tissues, however, are generally normal, and there is a paradoxical increase in intestinal iron absorption and iron storage. To test the hypothesis that the Trf cycle has unique importance for erythropoiesis, we disrupted the Trfr gene in mice. This results in elimination of the Trf cycle, but leaves other Trf functions intact. Mice lacking Trfr have a more severe phenotype than hpx mice, affecting both erythropoiesis and neurologic development. Furthermore, haploinsufficiency for Trfr results in impaired erythroid development and abnormal iron homeostasis.     

The structure of isocedrolic acid isolated fromJuniperus squamata Lamb

Summary Isocedrolic acid isolated fromJuniperus squamata Lamb. was established as 8s-hydroxycedrane-12-carboxylic acid by chemical and physical evidence.     

Preparation of Highly Luminescent Nanocomposite by Chelating Copolymer

1 Introduction Quantum-confined semiconductor nanocrystallite, which diameters are less than their bulk exciton diameter, have been the focus of much investigation recently~([1-4]).Because the difference in crystalline structure and size of semiconductor materials lead to considerable change in the effective masses of electrons and holes in their electronic bands, thus, their size and structure of crystalline of semiconductor nanocrystallinites is an important factor for determining their opti…     

Keyword Extraction Based on tf/idf for Chinese News Document

Keyword extraction is an important research topic of information retrieval. This paper gave the specification of keywords in Chinese news documents based on analyzing linguistic characteristics of news documents and then proposed a new keyword extraction method based on tf/idf with multi-strategies. The approach selected candidate keywords of uni-, hi- and tri-grams, and then defines the features according to their morphological characters and context information. Moreover, the paper proposed several strategies to amend the incomplete words gotten from the word segmentation and found unknown potential keywords in news documents. Experimental results show that our proposed method can significantly outperform the baseline method. We also applied it to retrospective event detection. Experimental results show that the accuracy and efficiency of news retrospective event detection can be significantly improved.     

能量有效的无线传感器网络数据收集协议

针对无线传感器网络(wireless sensor networks,WSNs)中数据收集易丢失的特点,提出了一种能量有效的数据收集协议?该协议引入链路质量门限来构造骨干投递网,提高链路可靠性?在构造算法中分配的核结点和非核节点分别采用2种不同的时隙调度表来进行数据传输,该调度算法让暂时不参与数据传输的节点进入睡眠模式,降低节点能量消耗?协议采用管道投递(pipeline delivery)模式进行数据传输,避免传输过程中的互干扰?TOSSIM实验仿真表明,与CTP(collection tree protocol)协议相比,该协议在不计算睡眠调度算法获得的能量增益情况下,仍获得较好的传输开销和更高的能量利用率,减小了网络整体能耗?