基于长期健康监测数据的混凝土单箱三室箱梁遮阴效应

单箱三室箱梁温度效应复杂,在王家河特大桥箱梁混凝土内埋置了89个温度传感器、并布置了光电辐射传感器与风速传感器,采集频率均为1次/20min。利用无线采集模块进行数据采集,得到单箱三室箱梁太阳辐射温度场分布规律。研究结果表明：太阳辐射测试结果存在季节性,夏季太阳辐射强烈,风速测试结果无明显季节性;受太阳辐射作用影响,向阳侧边腹板竖向温度梯度大于背阳侧竖向温度梯度,夏季竖向温度梯度大于冬季温度梯度;受对流作用影响,中腹板除顶底部测点外变化极小可被忽略;受太阳高度角影响,冬季向阳侧照射时间比夏季长。冬季箱梁最大横向温度梯度为12.0℃,大于夏季的4.7℃;箱梁横向温度梯度成U型分布,背阳侧横向温度梯度的98%超越概率值为6.472℃,首次提出基于向阳侧和背阳侧温度梯度的中国铁路规范的修正公式;建立考虑遮阴长度的温度场模型,揭示了向阳侧腹板横向温度梯度冬季大于夏季的原因。     

浅谈施工企业员工培训

文章论述了如何搞好施工企业员工培训,全面提高员工素质以提高企业核心竞争力,使企业适应建筑市场新形势并获得发展.     

某导弹弹托热流变机制及成形过程分析

本文用热变加工的观点讨论了导弹弹托的热流变机制和成形过程。本文中,材料被认为是具有微极特性的广义连续介质。基于弹粘性微极理论,在本构方程中加入反映材料屈服特性的项λ_p,并将弹一粘性微极本构方程推广为弹一粘一塑性微极本构方程。根据这些条件,得到了描述材料在模腔内流动的基本方程,并建立了柱坐标形式下的流动方程。     

An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis

Osteoarthritis is the most common form of human arthritis. We investigated the potential role of asporin, an extracellular matrix component expressed abundantly in the articular cartilage of individuals with osteoarthritis, in the pathogenesis of osteoarthritis. Here we report a significant association between a polymorphism in the aspartic acid (D) repeat of the gene encoding asporin (ASPN) and osteoarthritis. In two independent populations of individuals with knee osteoarthritis, the D14 allele of ASPN is over-represented relative to the common D13 allele, and its frequency increases with disease severity. The D14 allele is also over-represented in individuals with hip osteoarthritis. Asporin suppresses TGF-beta-mediated expression of the genes aggrecan (AGC1) and type II collagen (COL2A1) and reduced proteoglycan accumulation in an in vitro model of chondrogenesis. The effect on TGF-beta activity is allele-specific, with the D14 allele resulting in greater inhibition than other alleles. In vitro binding assays showed a direct interaction between asporin and TGF-beta. Taken together, these findings provide another functional link between extracellular matrix proteins, TGF-beta activity and disease, suggesting new therapeutic strategies for osteoarthritis.     

Electronic Payment Scheme to Prevent the Treachery

0 IntroductionWith the development of the Internet ,the demand forelectronic commerce is urgent . But few people canconduct electronic business securely at anyti me and anywhere,because the existed electronic business systems ,especially theelectronic payment systems ,have some secure problems . Oneof the most seriousl is the treachery.Here the treachery is means that all the participants inelectronic business could cheat to get some benefits alone orassociated with others in transaction in a…     

Dissociation of avidin-biotin complex in vivo

Zusammenfassung Es wurde mittels des mit¹⁴C markierten Biotins und mit¹³¹J markierten Avidins gezeigt, dass der Avidin-Biotin-Komplex, i.p. oder i.v. in Ratten injiziert, dissoziert war.

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This work was supported by a grant from the China Medical Board of New York, Inc. (Grant No. 70-127).     

可拓评价方法在招标评标中的应用

根据物元的可拓性理论,针对建筑工程中的实际问题,给出了由简单关联函数确定建筑工程招标评标中权得的新方法,从可拓性学的基本特色出发,采用物元的发散性思维,研究可拓方法在工程招标招标中的应用,并提出了工程招标评标中的物元模型,最后给出了可拓性评价方法在工程招标评标中的应用实例。     

地方应用型大学图书馆发展趋势及应对策略

地方应用型大学兼重"地方"和"应用"两个特性,因此,在参照学校发展方向规划和配置文献信息资源的同时,还应立足所在区域的经济文化社会需求,围绕学校产学研参与各种社会信息资源共建共享,并参与到对地方历史文明的传承和精神文明的带动中去。     

Glutamate transporter EAAT2: regulation,function, and potential as a therapeutic target for neurological and psychiatric disease

Glutamate is the predominant excitatory neurotransmitter in the central nervous system. Excitatory amino acid transporter 2 (EAAT2) is primarily responsible for clearance of extracellular glutamate to prevent neuronal excitotoxicity and hyperexcitability. EAAT2 plays a critical role in regulation of synaptic activity and plasticity. In addition, EAAT2 has been implicated in the pathogenesis of many central nervous system disorders. In this review, we summarize current understanding of EAAT2, including structure, pharmacology, physiology, and functions, as well as disease relevancy, such as in stroke, Parkinson’s disease, epilepsy, amyotrophic lateral sclerosis, Alzheimer’s disease, major depressive disorder, and addiction. A large number of studies have demonstrated that up-regulation of EAAT2 protein provides significant beneficial effects in many disease models suggesting EAAT2 activation is a promising therapeutic approach. Several EAAT2 activators have been identified. Further understanding of EAAT2 regulatory mechanisms could improve development of drug-like compounds that spatiotemporally regulate EAAT2.     

基于能量法的结构瞬时最优控制的参数影响

基于瞬时最优控制方法和能量法的基本原理研究,推导出瞬时最优控制算法的能量平衡等式.进行基于能量法的瞬时最优控制算法的参数分析,考察时间间隔对结构动力反应以及结构能量分配的影响.结果表明:时间间隔增大会使结构的位移和速度响应减小,对加速度反应的影响还与结构自振周期相关;对能量分配的影响也随之减小;控制力和控制能与时间间隔和位移或速度的综合作用相关,时间间隔越大,输入地震动能量受结构周期影响越小.