基于复合左/右手传输线的双频微带贴片天线(英文)

复合左/右手传输线(CRLH TL)是一种兼具左手材料和右手材料性质的超电磁介质,其以奇异的特性受到科学界及工程界的重视.在微带天线领域,复合左/右手传输线结构可用于馈电网络、辐射单元,以及背景媒质的设计.采用复合左/右手传输线结构同时作为馈电电路及辐射单元,实现了同轴线与辐射贴片的良好匹配,以及天线的双频辐射特性.通过在复合左/右手传输线天线的接地板上加载缝隙,实现了调节天线谐振频率的目的.     

超声界面波在充液双金属复合管道中的传播特性分析

随着管道运输行业的发展,复合管道越来越多地应用于机械、能源、化工等领域.利用超声界面波对复合管道的界面位置进行损伤探测成为机械装备超声无损检测研究的新方向.以充液金属复合管道为研究对象,采用多物理场有限元分析软件建立了充液复合管道的有限元模型,利用电信号激励超声界面波,分析了超声界面波在管道中的传播特性,并分析了不同液...     

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy.     

Male-pattern baldness susceptibility locus at 20p11

We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both 20p11.22 and AR (encoding the androgen receptor) has a sevenfold-increased odds of androgenic alopecia (OR = 7.12, P = 3.7 x 10(-15)).     

The pathogenesis of cardiac fibrosis

Cardiac fibrosis is characterized by net accumulation of extracellular matrix proteins in the cardiac interstitium, and contributes to both systolic and diastolic dysfunction in many cardiac pathophysiologic conditions. This review discusses the cellular effectors and molecular pathways implicated in the pathogenesis of cardiac fibrosis. Although activated myofibroblasts are the main effector cells in the fibrotic heart, monocytes/macrophages, lymphocytes, mast cells, vascular cells and cardiomyocytes may also contribute to the fibrotic response by secreting key fibrogenic mediators. Inflammatory cytokines and chemokines, reactive oxygen species, mast cell-derived proteases, endothelin-1, the renin/angiotensin/aldosterone system, matricellular proteins, and growth factors (such as TGF-β and PDGF) are some of the best-studied mediators implicated in cardiac fibrosis. Both experimental and clinical evidence suggests that cardiac fibrotic alterations may be reversible. Understanding the mechanisms responsible for initiation, progression, and resolution of cardiac fibrosis is crucial to design anti-fibrotic treatment strategies for patients with heart disease.     

Identification of low-frequency variants associated with gout and serum uric acid levels

We tested 16 million SNPs, identified through whole-genome sequencing of 457 Icelanders, for association with gout and serum uric acid levels. Genotypes were imputed into 41,675 chip-genotyped Icelanders and their relatives, for effective sample sizes of 968 individuals with gout and 15,506 individuals for whom serum uric acid measurements were available. We identified a low-frequency missense variant (c.1580C>G) in ALDH16A1 associated with gout (OR = 3.12, P = 1.5 × 10(-16), at-risk allele frequency = 0.019) and serum uric acid levels (effect = 0.36 s.d., P = 4.5 × 10(-21)). We confirmed the association with gout by performing Sanger sequencing on 6,017 Icelanders. The association with gout was stronger in males relative to females. We also found a second variant on chromosome 1 associated with gout (OR = 1.92, P = 0.046, at-risk allele frequency = 0.986) and serum uric acid levels (effect = 0.48 s.d., P = 4.5 × 10(-16)). This variant is close to a common variant previously associated with serum uric acid levels. This work illustrates how whole-genome sequencing data allow the detection of associations between low-frequency variants and complex traits.     

复方蒙药广枣-肉豆蔻片的制备与质量控制

研究了广枣-肉豆蔻片的制备过程并对其质量进行控制。基于《中国药典》(2020年版)片剂项要求,考察片剂的外观性状、硬度、崩解时限、重量差异及脆碎度;采用高效液相色谱法测定广枣-肉豆蔻片中4种抗氧化成分的含量。结果表明,片剂外表光滑,色泽均匀,硬度值处于30～40 N,崩解时限控制在10 min内,脆碎度小于1%;槲皮素、原儿茶酸、甲基丁香酚、肉豆蔻醚分别在0.16～0.8μg/mL(r=0.999)、4～20μg/mL(r=0.999)、8～40μg/mL(r=0.999)、100～500μg/mL(r=0.999)内呈良好的线性关系,平均回收率分别为99.3%、101.6%、100.3%、99.3%。且方法学验证项下精密度、稳定性和重复性试验的相对标准偏差(relative standard deviation, RSD)数值均未超过2%。该含量测定方法操作简便、专属性强、结果准确可靠,可为复方蒙药广枣-肉豆蔻片的质量标准提供参考。     

pH-responsive poly（2-diethylaminoethyl methacrylate）-functionalized multiwalled carbon nanotubes

Poly（2-diethylaminoethyl methacrylate） （PDEAEMA）-coated multiwalled carbon nanotubes （MWNT-PDEAEMA） were successfully prepared by MWNT-surface initiated atom transfer radical polymerization （ATRP）. The obtained MWNT-PDEAEMA nanocylinders have a core of MWNT and a shell of PDEAEMA and this core-shell structure was confirmed by TEM observations. The UV-Vis and AFM measurements showed that the MWNT-PDEAEMA exhibited obvious pH sensitivity. The solubility of PDEAEMA-coated MWNT dramatically decreased when pH increased to ca. 7.0. Because of the giant molecular weight of the molecular hybrids and local high density of polymeric grafts linked onto MWNTs, the resulting MWNT-PDEAEMA nanocomposites are easier to aggregate, or more sensitive to pH, as compared with the neat PDEAEMA.