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排序方式: 共有139条查询结果,搜索用时 328 毫秒
1.
2.
作者对采用非质量分离离子束注入沉积法(IBD)在Si(100)上制备的β-FeSi2薄膜进行了研究,通过X射线衍射(XRD)和扫描电镜(SEM)以及原子力显微镜(AFM)分析表明:当退火温度在600℃和700℃附近时有利于β-FeSi2的形成。 相似文献
3.
Taiho Kambe Ayako Hashimoto Shigeyuki Fujimoto 《Cellular and molecular life sciences : CMLS》2014,71(17):3281-3295
Zinc transporters, the Zrt-, Irt-like protein (ZIP) family and the Zn transporter (ZnT) family transporters, are found in all aspects of life. Increasing evidence has clarified the molecular mechanism, in which both transporters play critical roles in cellular and physiological functions via mobilizing zinc across the cellular membrane. In the last decade, mutations in ZIP and ZnT transporter genes have been shown to be implicated in a number of inherited human diseases. Moreover, dysregulation of expression and activity of both transporters has been suggested to be involved in the pathogenesis and progression of chronic diseases including cancer, immunological impairment, and neurodegenerative diseases, although comprehensive understanding is far from complete. The diverse phenotypes of diseases related to ZIP and ZnT transporters reflect the multifarious biological functions of both transporters. The present review summarizes the current understanding of ZIP and ZnT transporter functions from the standpoint of human health and diseases. The study of zinc transporters is currently of great clinical interest. 相似文献
4.
The genome sequence and structure of rice chromosome 1 总被引:2,自引:0,他引:2
Sasaki T Matsumoto T Yamamoto K Sakata K Baba T Katayose Y Wu J Niimura Y Cheng Z Nagamura Y Antonio BA Kanamori H Hosokawa S Masukawa M Arikawa K Chiden Y Hayashi M Okamoto M Ando T Aoki H Arita K Hamada M Harada C Hijishita S Honda M Ichikawa Y Idonuma A Iijima M Ikeda M Ikeno M Ito S Ito T Ito Y Ito Y Iwabuchi A Kamiya K Karasawa W Katagiri S Kikuta A Kobayashi N Kono I Machita K Maehara T Mizuno H Mizubayashi T Mukai Y Nagasaki H Nakashima M Nakama Y Nakamichi Y Nakamura M Namiki N 《Nature》2002,420(6913):312-316
The rice species Oryza sativa is considered to be a model plant because of its small genome size, extensive genetic map, relative ease of transformation and synteny with other cereal crops. Here we report the essentially complete sequence of chromosome 1, the longest chromosome in the rice genome. We summarize characteristics of the chromosome structure and the biological insight gained from the sequence. The analysis of 43.3 megabases (Mb) of non-overlapping sequence reveals 6,756 protein coding genes, of which 3,161 show homology to proteins of Arabidopsis thaliana, another model plant. About 30% (2,073) of the genes have been functionally categorized. Rice chromosome 1 is (G + C)-rich, especially in its coding regions, and is characterized by several gene families that are dispersed or arranged in tandem repeats. Comparison with a draft sequence indicates the importance of a high-quality finished sequence. 相似文献
5.
基于电子束物理气相沉积法制备纳米薄膜的悬浮工艺,采用一维稳态恒热流加热法实验测量了80—300K厚度为23nm金薄膜的面向导热系数.研究表明金纳米薄膜的面向导热系数有非常显著的尺寸效应:金纳米薄膜的面向导热系数大大低于体材料的值,并且导热系数随温度的升高而增大,这一趋势与体材料导热系数的温度依赖性相反;同时,金纳米薄膜的Lorenz数大约为体材料值的3倍,并且随着温度的升高有减小的趋势,表明Wiedemann-Franz定律对于金纳米薄膜不再适用. 相似文献
6.
Sister chromatids are held together by cohesins. At anaphase, separase is activated by degradation of its inhibitory partner, securin. Separase then cleaves cohesins, thus allowing sister chromatid separation. Fission yeast securin (Cut2) has destruction boxes and a separase (Cut1) interaction site in the amino and carboxyl terminus, respectively. Here we show that securin is essential for separase stability and also for proper repair of DNA damaged by ultraviolet, X-ray and gamma-ray irradiation. The cut2(EA2) mutant is defective in the repair of ultraviolet damage lesions, although the DNA damage checkpoint is activated normally. In double mutant analysis of ultraviolet sensitivity, checkpoint kinase chk1 (ref. 9) and excision repair rad13 (ref. 10) mutants were additive with cut2(EA2), whereas recombination repair rhp51 (ref. 11) and cohesin subunit rad21 (ref. 12) mutants were not. Cohesin was hyper-modified on ultraviolet irradiation in a Rad3 kinase-dependent way. Experiments using either mutant cohesin that cannot be cleaved by separase or a protease-dead separase provide evidence that this DNA repair function of securin-separase acts through the cleavage of cohesin. We propose that the securin-separase complex might aid DNA repair by removing local cohesin in interphase cells. 相似文献
7.
Effect of prostaglandin F2α on the secretion of pancreatic juice induced by secretin and by dopamine
Zusammenfassung Die Wirksamkeit von Prostaglandin F2 (PGF2) auf die exokrine Pankreassekretion wurde an einem mit Blut perfundiereten Pankreas-Präparat des Hundes untersucht. PGF2 (100 g) hemmte die durch Sekretin stimuliete, aber nicht die durch Dopamin stimulierte Sekretion. 相似文献
8.
Y Hashimoto 《Nature》1971,231(5301):316-317
9.
Yoshida Y Chiba T Tokunaga F Kawasaki H Iwai K Suzuki T Ito Y Matsuoka K Yoshida M Tanaka K Tai T 《Nature》2002,418(6896):438-442
N-glycosylation of proteins in the endoplasmic reticulum (ER) has a central role in protein quality control. Here we report that N-glycan serves as a signal for degradation by the Skp1-Cullin1-Fbx2-Roc1 (SCF(Fbx2)) ubiquitin ligase complex. The F-box protein Fbx2 (ref. 4) binds specifically to proteins attached to N-linked high-mannose oligosaccharides and subsequently contributes to ubiquitination of N-glycosylated proteins. Pre-integrin beta 1 is a target of Fbx2; these two proteins interact in the cytosol after inhibition of the proteasome. In addition, expression of the mutant Fbx2 Delta F, which lacks the F-box domain that is essential for forming the SCF complex, appreciably blocks degradation of typical substrates of the ER-associated degradation pathway. Our results indicate that SCF(Fbx2) ubiquitinates N-glycosylated proteins that are translocated from the ER to the cytosol by the quality control mechanism. 相似文献
10.