节理岩体的随机剪切破环

提出的节理岩体剪切强度准则,考虑了节理面、岩桥提供的强度分量和相邻节理面形成的起伏角提供的强度分量。讨论了节理面和节理岩体发生剪切破坏时某些关键应力状态必须满足的物理约束条件。此外,强度准则中的参数可以是随机变量,所以可以用于随机模型中的破坏概率分析和工程的风险分析。     

Towards a Feminist-Systems Theory

This paper provides the findings of a study to locate the similarity and/or differences between two epistemologies: critical systems thinking and cultural ecofeminism. Selected texts from authors in each field were coded and compared using the Constant comparative analysis, grounded theory method. The analysis revealed a multitude of similarities across a range of concepts, including systems thinking language; challenges to positivist science, reason and instrumentalism; ethics and morality and praxis. The analysis also revealed several emergent principles for working towards a feminist systems theory of practice.     

The influence of early nutrition and environmental rearing on brain growth and behaviour.

Preweaning malnutrition permanently reduced brain size and cellular content but in spite of changes in the adrenocotical stress response no learning deficit was observed. Differential rearing environments did not influence the effects of malnutrition.     

下一个世界是“牛”的世界 Nuendo基础教程

这天,我终于做了一个决定,我要做我的 Nuendo 教程,这天的天气一风和日丽!没有哪个音乐人不希望做出好的音乐,更没有哪个音乐人,不希望用好的软件,在硬是有人要喜欢 Cubase 绚丽的色彩时,我相信更是有人喜欢 Nuendo 的,虽然我们需要的不仅仅是一个软件的界面色彩。而同样从国人亲切的“牛犊“称呼中我们不难验证这样一句话:在未来的社会主义 MIDI 音乐发展道路上,“牛犊“将越来越牛,不断更牛!     

A distal enhancer and an ultraconserved exon are derived from a novel retroposon

Hundreds of highly conserved distal cis-regulatory elements have been characterized so far in vertebrate genomes. Many thousands more are predicted on the basis of comparative genomics. However, in stark contrast to the genes that they regulate, in invertebrates virtually none of these regions can be traced by using sequence similarity, leaving their evolutionary origins obscure. Here we show that a class of conserved, primarily non-coding regions in tetrapods originated from a previously unknown short interspersed repetitive element (SINE) retroposon family that was active in the Sarcopterygii (lobe-finned fishes and terrestrial vertebrates) in the Silurian period at least 410 million years ago (ref. 4), and seems to be recently active in the 'living fossil' Indonesian coelacanth, Latimeria menadoensis. Using a mouse enhancer assay we show that one copy, 0.5 million bases from the neuro-developmental gene ISL1, is an enhancer that recapitulates multiple aspects of Isl1 expression patterns. Several other copies represent new, possibly regulatory, alternatively spliced exons in the middle of pre-existing Sarcopterygian genes. One of these, a more than 200-base-pair ultraconserved region, 100% identical in mammals, and 80% identical to the coelacanth SINE, contains a 31-amino-acid-residue alternatively spliced exon of the messenger RNA processing gene PCBP2 (ref. 6). These add to a growing list of examples in which relics of transposable elements have acquired a function that serves their host, a process termed 'exaptation', and provide an origin for at least some of the many highly conserved vertebrate-specific genomic sequences.     

The Cenozoic palaeoenvironment of the Arctic Ocean

The history of the Arctic Ocean during the Cenozoic era (0-65 million years ago) is largely unknown from direct evidence. Here we present a Cenozoic palaeoceanographic record constructed from >400 m of sediment core from a recent drilling expedition to the Lomonosov ridge in the Arctic Ocean. Our record shows a palaeoenvironmental transition from a warm 'greenhouse' world, during the late Palaeocene and early Eocene epochs, to a colder 'icehouse' world influenced by sea ice and icebergs from the middle Eocene epoch to the present. For the most recent approximately 14 Myr, we find sedimentation rates of 1-2 cm per thousand years, in stark contrast to the substantially lower rates proposed in earlier studies; this record of the Neogene reveals cooling of the Arctic that was synchronous with the expansion of Greenland ice (approximately 3.2 Myr ago) and East Antarctic ice (approximately 14 Myr ago). We find evidence for the first occurrence of ice-rafted debris in the middle Eocene epoch (approximately 45 Myr ago), some 35 Myr earlier than previously thought; fresh surface waters were present at approximately 49 Myr ago, before the onset of ice-rafted debris. Also, the temperatures of surface waters during the Palaeocene/Eocene thermal maximum (approximately 55 Myr ago) appear to have been substantially warmer than previously estimated. The revised timing of the earliest Arctic cooling events coincides with those from Antarctica, supporting arguments for bipolar symmetry in climate change.     

A universal trend of amino acid gain and loss in protein evolution

Amino acid composition of proteins varies substantially between taxa and, thus, can evolve. For example, proteins from organisms with (G + C)-rich (or (A + T)-rich) genomes contain more (or fewer) amino acids encoded by (G + C)-rich codons. However, no universal trends in ongoing changes of amino acid frequencies have been reported. We compared sets of orthologous proteins encoded by triplets of closely related genomes from 15 taxa representing all three domains of life (Bacteria, Archaea and Eukaryota), and used phylogenies to polarize amino acid substitutions. Cys, Met, His, Ser and Phe accrue in at least 14 taxa, whereas Pro, Ala, Glu and Gly are consistently lost. The same nine amino acids are currently accrued or lost in human proteins, as shown by analysis of non-synonymous single-nucleotide polymorphisms. All amino acids with declining frequencies are thought to be among the first incorporated into the genetic code; conversely, all amino acids with increasing frequencies, except Ser, were probably recruited late. Thus, expansion of initially under-represented amino acids, which began over 3,400 million years ago, apparently continues to this day.