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排序方式: 共有643条查询结果,搜索用时 203 毫秒
601.
AIM: To investigate treatment outcome of Helicobacter pylori (H.pylori )-negative low-grade gastric mucosaassociated lymphoid tissue (MALT) lymphoma.METHODS: In this study,we retrospectively reviewed the clinical outcome and clinicopathologic factors of stage Ⅰ E H.pylori -negative low-grade gastric MALT lymphoma cases from August 1998 to June 2009.RESULTS: A total of eleven patients with H.pylori -negative low-grade gastric MALT lymphoma were enrolled in the study and received anti-H.pylori eradication tre... 相似文献
602.
聚合物纳米复合材料因其分散相的高度精细化和纳米尺寸效应而具有与传统复合材料明显不同的力学性能和功能性能。其中,层状硅酸盐聚合物纳米复合材料又以分散相的高形状系数比而具有更为突出或特异的性能,如高刚性、高强度、高阻隔、高阻燃性等。因此聚合物纳米复合材料自问世以来便受到各国学者和工业界广泛关注。在轮胎气密层橡胶中,可以充分利用纳米层状硅酸盐材料的高阻隔性,从而起到提高气密性的作用。更进一步的应用研究表明,可以通过使用纳米层状硅酸盐填充橡胶作为气密层,在不损失气密性的情况下,减少气密层厚度,从而降低轮胎重量,实现原价节俭和滚动阻力降低的双重效果。 相似文献
603.
应用光纤布拉格光栅温度传感器和应变传感器现场监测了混凝土挡土墙浇注早期的变形和温度变化情况。由于光纤布拉格光栅同时感应温度和变形,需要用布拉格光栅温度传感器对应变传感器进行温度补偿。监测结果表明,光纤布拉格光栅监测系统适用于混凝土早期性能的现场监测,通过与普通传感器监测结果对比,光纤传感器的结果更稳定,准确,且该监测系统可继续对混凝土结构的中长期性能进行实时监测。 相似文献
604.
The existing active queue management (AQM) algorithm acts on subscribers and edge routers only, it does not support differentiate-serve (Diffserv) quality of service (QoS), while the existing diffserv QoS has not considered the link capacities between edge routers and connected core routers. When a core router in a two layers’ network experiences congestion, the connected edge routers have no ability to adjust their access data rates. Thus, it is difficult to achieve the congestion control for the large scale network with many edge routers and core routers. To solve these problems, two difffserve AQM algorithms are proposed for the congestion control of multilayer network. One diffserv AQM algorithm implements fair link capacities of edge routers, and the other one implements unequal link capacities of edge routers, but it requires the core routers to have multi-queues buffers and Diffserv AQM to support. The proposed algorithms achieve the network congestion control by operating AQM parameters on the conditions of proposed three theorems for core and edge routers. The dynamic simulation results demonstrate the proposed control algorithms for core and edge routers to be valid. 相似文献
605.
Gurumurthy S Xie SZ Alagesan B Kim J Yusuf RZ Saez B Tzatsos A Ozsolak F Milos P Ferrari F Park PJ Shirihai OS Scadden DT Bardeesy N 《Nature》2010,468(7324):659-663
Haematopoietic stem cells (HSCs) can convert between growth states that have marked differences in bioenergetic needs. Although often quiescent in adults, these cells become proliferative upon physiological demand. Balancing HSC energetics in response to nutrient availability and growth state is poorly understood, yet essential for the dynamism of the haematopoietic system. Here we show that the Lkb1 tumour suppressor is critical for the maintenance of energy homeostasis in haematopoietic cells. Lkb1 inactivation in adult mice causes loss of HSC quiescence followed by rapid depletion of all haematopoietic subpopulations. Lkb1-deficient bone marrow cells exhibit mitochondrial defects, alterations in lipid and nucleotide metabolism, and depletion of cellular ATP. The haematopoietic effects are largely independent of Lkb1 regulation of AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) signalling. Instead, these data define a central role for Lkb1 in restricting HSC entry into cell cycle and in broadly maintaining energy homeostasis in haematopoietic cells through a novel metabolic checkpoint. 相似文献
606.
Transient receptor potential (TRP) ion channels have been identified as cellular sensors responding to diverse external and
internal stimuli. This review will cover the TRPV subfamily that comprises vertebrate and invertebrate members. The six mammalian
TRPV channels were demonstrated to function in thermosensation, mechanosensation, osmosensation and Ca2+ uptake. Invertebrate TRPV channels, five in Caenorhabditis elegans and two in Drosophila, have been shown to play a role in mechanosensation, such as hearing and proprioception in Drosophila and nose touch in C. elegans, and in the response to osmotic and chemical stimuli in C. elegans. We will focus here on the role that TRPV ion channels play in mechanosensation and a related sensory (sub-)modality, osmosensation.
Received 2 May 2005; received after revision 30 July 2005; accepted 30 August 2005 相似文献
607.
608.
Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9 总被引:21,自引:0,他引:21
The low-density lipoprotein receptor (LDLR) prevents hypercholesterolemia and atherosclerosis by removing low-density lipoprotein (LDL) from circulation. Mutations in the genes encoding either LDLR or its ligand (APOB) cause severe hypercholesterolemia. Missense mutations in PCSK9, encoding a serine protease in the secretory pathway, also cause hypercholesterolemia. These mutations are probably gain-of-function mutations, as overexpression of PCSK9 in the liver of mice produces hypercholesterolemia by reducing LDLR number. To test whether loss-of-function mutations in PCSK9 have the opposite effect, we sequenced the coding region of PCSK9 in 128 subjects (50% African American) with low plasma levels of LDL and found two nonsense mutations (Y142X and C679X). These mutations were common in African Americans (combined frequency, 2%) but rare in European Americans (<0.1%) and were associated with a 40% reduction in plasma levels of LDL cholesterol. These data indicate that common sequence variations have large effects on plasma cholesterol levels in selected populations. 相似文献
609.
Calmodulin interacts with MLO protein to regulate defence against mildew in barley 总被引:29,自引:0,他引:29
Kim MC Panstruga R Elliott C Müller J Devoto A Yoon HW Park HC Cho MJ Schulze-Lefert P 《Nature》2002,416(6879):447-451
In plants, defence against specific isolates of a pathogen can be triggered by the presence of a corresponding race-specific resistance gene, whereas resistance of a more broad-spectrum nature can result from recessive, presumably loss-of-regulatory-function, mutations. An example of the latter are mlo mutations in barley, which have been successful in agriculture for the control of powdery mildew fungus (Blumeria graminis f. sp. hordei; Bgh). MLO protein resides in the plasma membrane, has seven transmembrane domains, and is the prototype of a sequence-diversified family unique to plants, reminiscent of the seven-transmembrane receptors in fungi and animals. In animals, these are known as G-protein-coupled receptors and exist in three main families, lacking sequence similarity, that are thought to be an example of molecular convergence. MLO seems to function independently of heterotrimeric G proteins. We have identified a domain in MLO that mediates a Ca2+-dependent interaction with calmodulin in vitro. Loss of calmodulin binding halves the ability of MLO to negatively regulate defence against powdery mildew in vivo. We propose a sensor role for MLO in the modulation of defence reactions. 相似文献
610.