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排序方式: 共有343条查询结果,搜索用时 15 毫秒
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DE Neafsey K Galinsky RH Jiang L Young SM Sykes S Saif S Gujja JM Goldberg S Young Q Zeng SB Chapman AP Dash AR Anvikar PL Sutton BW Birren AA Escalante JW Barnwell JM Carlton 《Nature genetics》2012,44(9):1046-1050
We sequenced and annotated the genomes of four P. vivax strains collected from disparate geographic locations, tripling the number of genome sequences available for this understudied parasite and providing the first genome-wide perspective of global variability in this species. We observe approximately twice as much SNP diversity among these isolates as we do among a comparable collection of isolates of P. falciparum, a malaria-causing parasite that results in higher mortality. This indicates a distinct history of global colonization and/or a more stable demographic history for P. vivax relative to P. falciparum, which is thought to have undergone a recent population bottleneck. The SNP diversity, as well as additional microsatellite and gene family variability, suggests a capacity for greater functional variation in the global population of P. vivax. These findings warrant a deeper survey of variation in P. vivax to equip disease interventions targeting the distinctive biology of this neglected but major pathogen. 相似文献
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Expression of oncogenes in otherwise normal cells often leads to the activation of anti-oncogenic pathways through a poorly understood process described as 'oncogenic stress'. A new study implicates the Jnk pathway signaling in the activation of p53 in response to both K-Ras and Neu oncogene expression. 相似文献
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Brown KM Macgregor S Montgomery GW Craig DW Zhao ZZ Iyadurai K Henders AK Homer N Campbell MJ Stark M Thomas S Schmid H Holland EA Gillanders EM Duffy DL Maskiell JA Jetann J Ferguson M Stephan DA Cust AE Whiteman D Green A Olsson H Puig S Ghiorzo P Hansson J Demenais F Goldstein AM Gruis NA Elder DE Bishop JN Kefford RF Giles GG Armstrong BK Aitken JF Hopper JL Martin NG Trent JM Mann GJ Hayward NK 《Nature genetics》2008,40(7):838-840
We conducted a genome-wide association pooling study for cutaneous melanoma and performed validation in samples totaling 2,019 cases and 2,105 controls. Using pooling, we identified a new melanoma risk locus on chromosome 20 (rs910873 and rs1885120), with replication in two further samples (combined P < 1 x 10(-15)). The per allele odds ratio was 1.75 (1.53, 2.01), with evidence for stronger association in early-onset cases. 相似文献
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Identification of ten loci associated with height highlights new biological pathways in human growth 总被引:1,自引:0,他引:1
Lettre G Jackson AU Gieger C Schumacher FR Berndt SI Sanna S Eyheramendy S Voight BF Butler JL Guiducci C Illig T Hackett R Heid IM Jacobs KB Lyssenko V Uda M;Diabetes Genetics Initiative;FUSION;KORA;Prostate Lung Colorectal Ovarian Cancer Screening Trial;Nurses' Health Study;SardiNIA Boehnke M Chanock SJ Groop LC Hu FB Isomaa B Kraft P Peltonen L Salomaa V Schlessinger D Hunter DJ Hayes RB Abecasis GR Wichmann HE Mohlke KL Hirschhorn JN 《Nature genetics》2008,40(5):584-591
Height is a classic polygenic trait, reflecting the combined influence of multiple as-yet-undiscovered genetic factors. We carried out a meta-analysis of genome-wide association study data of height from 15,821 individuals at 2.2 million SNPs, and followed up the strongest findings in >10,000 subjects. Ten newly identified and two previously reported loci were strongly associated with variation in height (P values from 4 x 10(-7) to 8 x 10(-22)). Together, these 12 loci account for approximately 2% of the population variation in height. Individuals with < or =8 height-increasing alleles and > or =16 height-increasing alleles differ in height by approximately 3.5 cm. The newly identified loci, along with several additional loci with strongly suggestive associations, encompass both strong biological candidates and unexpected genes, and highlight several pathways (let-7 targets, chromatin remodeling proteins and Hedgehog signaling) as important regulators of human stature. These results expand the picture of the biological regulation of human height and of the genetic architecture of this classical complex trait. 相似文献
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对当前三峡库区消落带新生湿地的相关研究进展进行了分类综述,主要包括三峡库区湿地植物生态学研究、湿地生态环境问题研究、湿地保护与可持续利用研究、湿地土壤理化性质研究等4个方面。然而,现有研究中存在的一些不足,主要包括:基础理论与实践研究不够深入;与周边环境耦合关系研究较少;动态研究不足;湿地的空间分布与类型划分不明确;与全球变化关系研究十分薄弱。最后指出,三峡库区湿地研究必将是多学科交叉研究;湿地生态系统的恢复与重构,生态系统演替的长期监测,湿地开发与利用在相当长一段时间内仍是热点;长期定位观测技术、“3S”技术、计算机模拟等技术与方法将会广泛应用于三峡库区湿地的研究。
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了解星系对的空间分布和随时间的演化是研究星系的形成和演化的重要手段之一,而其中完备星系对样本的选择是研究的关键.比起光学波段,在红外波段选择和观测星系对有很多优势.介绍了利用红外望远镜Spitzer卫星的SWIRE(the Spitzer Wide-area Infra Red Extragalactic survey)数据选择完备星系对样本的新方法,比较分析了星系对选源标准,得到了初步星系对样本. 相似文献