全文获取类型
收费全文 | 11889篇 |
免费 | 24篇 |
国内免费 | 42篇 |
专业分类
系统科学 | 35篇 |
丛书文集 | 80篇 |
教育与普及 | 32篇 |
理论与方法论 | 42篇 |
现状及发展 | 5134篇 |
研究方法 | 568篇 |
综合类 | 5908篇 |
自然研究 | 156篇 |
出版年
2013年 | 97篇 |
2012年 | 193篇 |
2011年 | 333篇 |
2010年 | 85篇 |
2009年 | 59篇 |
2008年 | 191篇 |
2007年 | 226篇 |
2006年 | 204篇 |
2005年 | 228篇 |
2004年 | 209篇 |
2003年 | 211篇 |
2002年 | 201篇 |
2001年 | 381篇 |
2000年 | 365篇 |
1999年 | 264篇 |
1992年 | 233篇 |
1991年 | 180篇 |
1990年 | 204篇 |
1989年 | 190篇 |
1988年 | 201篇 |
1987年 | 205篇 |
1986年 | 160篇 |
1985年 | 248篇 |
1984年 | 170篇 |
1983年 | 149篇 |
1982年 | 166篇 |
1981年 | 136篇 |
1980年 | 170篇 |
1979年 | 385篇 |
1978年 | 292篇 |
1977年 | 289篇 |
1976年 | 249篇 |
1975年 | 287篇 |
1974年 | 309篇 |
1973年 | 308篇 |
1972年 | 344篇 |
1971年 | 344篇 |
1970年 | 428篇 |
1969年 | 361篇 |
1968年 | 383篇 |
1967年 | 351篇 |
1966年 | 319篇 |
1965年 | 203篇 |
1959年 | 108篇 |
1958年 | 204篇 |
1957年 | 137篇 |
1956年 | 123篇 |
1955年 | 105篇 |
1954年 | 81篇 |
1948年 | 83篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
871.
872.
Zinc-indium-tin oxide (ZITO) films were grown by pulsed-laser deposition.Three different material compositions were investigated:ZITO-30,ZITO-50 and ZITO-70 in which 30%,50% and 70%,respectively,of the... 相似文献
873.
Aquatic sex pheromone from a male tree frog. 总被引:3,自引:0,他引:3
874.
875.
A family of mammalian Na+-dependent L-ascorbic acid transporters. 总被引:10,自引:0,他引:10
H Tsukaguchi T Tokui B Mackenzie U V Berger X Z Chen Y Wang R F Brubaker M A Hediger 《Nature》1999,399(6731):70-75
Vitamin C (L-ascorbic acid) is essential for many enzymatic reactions, in which it serves to maintain prosthetic metal ions in their reduced forms (for example, Fe2+, Cu+), and for scavenging free radicals in order to protect tissues from oxidative damage. The facilitative sugar transporters of the GLUT type can transport the oxidized form of the vitamin, dehydroascorbic acid, but these transporters are unlikely to allow significant physiological amounts of vitamin C to be taken up in the presence of normal glucose concentrations, because the vitamin is present in plasma essentially only in its reduced form. Here we describe the isolation of two L-ascorbic acid transporters, SVCT1 and SVCT2, from rat complementary DNA libraries, as the first step in investigating the importance of L-ascorbic acid transport in regulating the supply and metabolism of vitamin C. We find that SVCT1 and SVCT2 each mediate concentrative, high-affinity L-ascorbic acid transport that is stereospecific and is driven by the Na+ electrochemical gradient. Despite their close sequence homology and similar functions, the two isoforms of the transporter are discretely distributed: SVCT1 is mainly confined to epithelial systems (intestine, kidney, liver), whereas SVCT2 serves a host of metabolically active cells and specialized tissues in the brain, eye and other organs. 相似文献
876.
Substantial increase of protein stability by multiple disulphide bonds 总被引:25,自引:0,他引:25
Disulphide bonds can significantly stabilize the native structures of proteins. The effect is presumed to be due mainly to a decrease in the configurational chain entropy of the unfolded polypeptide. In phage T4 lysozyme, a disulphide-free enzyme, engineered disulphide mutants that crosslink residues 3-97, 9-164 and 21-142 are significantly more stable than the wild-type protein. To investigate the effect of multiple-disulphide bonds on protein stability, mutants were constructed in which two or three stabilizing disulphide bridges were combined in the same protein. Reversible thermal denaturation shows that the increase in melting temperature resulting from the individual disulphide bonds is approximately additive. The triple-disulphide variant unfolds at a temperature 23.4 degrees C higher than wild-type lysozyme. The results demonstrate that a combination of disulphide bonds, each of which contributes to stability, can achieve substantial overall improvement in the stability of a protein. 相似文献
877.
G. Rossi V. Coiro L. Camellini D. Pignatti C. Davoli B. Lari R. Volpi P. Chiodera 《Cellular and molecular life sciences : CMLS》1985,41(12):1573-1574
Summary In order to establish whether thyrotropin-releasing hormone (TRH) inhibits lysine-vasopressin (LVP)-induced growth hormone (GH) release, six normal men were tested with LVP alone or in combination with TRH. LVP strikingly increased serum GH levels; this response was not altered by TRH. These results indicated that in man TRH is not involved in the control of GH secretion in response to LVP. 相似文献
878.
Summary In spring, the landing rate of flying European pine shoot beetles,Tomicus piniperda L., on injured Scots pine diminishes as colonization continues. This is due to olfactory cues that indicate progressive host degradation. Verbenone was shown to play a role in the beetle's recognition of this unsuitability of a formerly suitable host, since the compound was increasingly released from colonized tree sections as they aged, but not from uninfested sections. Also, the release of verbenone at natural rates in the forest inhibited the attraction of beetles to host monoterpenes. 相似文献
879.
880.