全文获取类型
收费全文 | 16961篇 |
免费 | 34篇 |
国内免费 | 37篇 |
专业分类
系统科学 | 74篇 |
丛书文集 | 263篇 |
教育与普及 | 30篇 |
理论与方法论 | 71篇 |
现状及发展 | 8026篇 |
研究方法 | 720篇 |
综合类 | 7674篇 |
自然研究 | 174篇 |
出版年
2013年 | 78篇 |
2012年 | 190篇 |
2011年 | 390篇 |
2008年 | 231篇 |
2007年 | 255篇 |
2006年 | 288篇 |
2005年 | 277篇 |
2004年 | 383篇 |
2003年 | 257篇 |
2002年 | 259篇 |
2001年 | 480篇 |
2000年 | 442篇 |
1999年 | 328篇 |
1994年 | 74篇 |
1992年 | 288篇 |
1991年 | 227篇 |
1990年 | 241篇 |
1989年 | 236篇 |
1988年 | 202篇 |
1987年 | 235篇 |
1986年 | 280篇 |
1985年 | 338篇 |
1984年 | 232篇 |
1983年 | 228篇 |
1982年 | 205篇 |
1981年 | 222篇 |
1980年 | 225篇 |
1979年 | 566篇 |
1978年 | 481篇 |
1977年 | 437篇 |
1976年 | 342篇 |
1975年 | 405篇 |
1974年 | 568篇 |
1973年 | 455篇 |
1972年 | 472篇 |
1971年 | 554篇 |
1970年 | 699篇 |
1969年 | 538篇 |
1968年 | 542篇 |
1967年 | 539篇 |
1966年 | 431篇 |
1965年 | 371篇 |
1964年 | 121篇 |
1959年 | 193篇 |
1958年 | 330篇 |
1957年 | 247篇 |
1956年 | 190篇 |
1955年 | 192篇 |
1954年 | 190篇 |
1948年 | 127篇 |
排序方式: 共有10000条查询结果,搜索用时 14 毫秒
161.
Zheng Liu Yuri G. Andreev A. Robert Armstrong Sergio Brutti Yu Ren Peter G. Bruce 《自然科学进展(英文版)》2013,23(3):235-244
Reducing the dimensions of electrode materials from the micron to the nanoscale can have a profound influence on their properties and hence on the performance of electrochemical devices,e.g.Li-ion batteries,that employ such electrodes.TiO2(B) has received growing interest as a possible anode for Li-ion batteries in recent years.It offers the possibility of higher energy storage compared with the commercialized Li4Ti5O12.Bulk,nanowire,nanotube,and nanoparticle morphologies have been prepared and studied.However,to date these materials have not be compared in one article.In the current review we first summarize the different synthesis methods for the preparation of nanostructured TiO2(B);then present the effects of size and shape on the electrochemical properties.Finally TiO2(B) with nanometer dimensions exhibit a higher capacity to store Li,regardless of rate,due to structural distortions inherent at the nanoscale. 相似文献
162.
The p66shc adaptor protein controls oxidative stress response and life span in mammals 总被引:44,自引:0,他引:44
Migliaccio E Giorgio M Mele S Pelicci G Reboldi P Pandolfi PP Lanfrancone L Pelicci PG 《Nature》1999,402(6759):309-313
Gene mutations in invertebrates have been identified that extend life span and enhance resistance to environmental stresses such as ultraviolet light or reactive oxygen species. In mammals, the mechanisms that regulate stress response are poorly understood and no genes are known to increase individual life span. Here we report that targeted mutation of the mouse p66shc gene induces stress resistance and prolongs life span. p66shc is a splice variant of p52shc/p46shc (ref. 2), a cytoplasmic signal transducer involved in the transmission of mitogenic signals from activated receptors to Ras. We show that: (1) p66shc is serine phosphorylated upon treatment with hydrogen peroxide (H2O2) or irradiation with ultraviolet light; (2) ablation of p66shc enhances cellular resistance to apoptosis induced by H2O2 or ultraviolet light; (3) a serine-phosphorylation defective mutant of p66shc cannot restore the normal stress response in p66shc-/- cells; (4) the p53 and p21 stress response is impaired in p66shc-/- cells; (5) p66shc-/- mice have increased resistance to paraquat and a 30% increase in life span. We propose that p66shc is part of a signal transduction pathway that regulates stress apoptotic responses and life span in mammals. 相似文献
163.
In the fast evolving field of nanoscience and nanotechnology,where size and shape are crucial in deciding the optoelectronic properties of nanomaterials,the understanding of size and shape dependent behavior is of direct relevance to device applications.Present study reports the synthesis of Au nanorods with well controlled aspect ratios,and the influence of the aspect ratio on the surface enhanced Raman scattering(SERS) activity using crystal violet(CV) as the probe molecule.The influence of pH and the concentrations of reducing agent and Ag ions in controlling the aspect ratio of gold nanorods are also investigated.The structural and optical properties of the synthesized samples have been characterized by transmission electron microscopy(TEM) and UV-visible absorption spectroscopy.The nonlinear optical(NLO) transmission of the Au nanorods investigated using the open aperture Z-scan technique revealed the absorption saturation followed by an optical limiting behavior,which may find potential applications in optoelectronic nanodevices. 相似文献
164.
Vitamin B12 (cobalamin) was identified nearly 80 years ago as the anti-pernicious anaemia factor in liver, and its importance in human health and disease has resulted in much work on its uptake, cellular transport and utilization. Plants do not contain cobalamin because they have no cobalamin-dependent enzymes. Deficiencies are therefore common in strict vegetarians, and in the elderly, who are susceptible to an autoimmune disorder that prevents its efficient uptake. In contrast, many algae are rich in vitamin B12, with some species, such as Porphyra yezoensis (Nori), containing as much cobalamin as liver. Despite this, the role of the cofactor in algal metabolism remains unknown, as does the source of the vitamin for these organisms. A survey of 326 algal species revealed that 171 species require exogenous vitamin B12 for growth, implying that more than half of the algal kingdom are cobalamin auxotrophs. Here we show that the role of vitamin B12 in algal metabolism is primarily as a cofactor for vitamin B12-dependent methionine synthase, and that cobalamin auxotrophy has arisen numerous times throughout evolution, probably owing to the loss of the vitamin B12-independent form of the enzyme. The source of cobalamin seems to be bacteria, indicating an important and unsuspected symbiosis. 相似文献
165.
Selective Smoothed Finite Element Method 总被引:2,自引:0,他引:2
T. T. Nauven G. R. Liu K. Y. Dai K. Y. Lam 《清华大学学报》2007,12(5):497-508
The paper examines three selective schemes for the smoothed finite element method (SFEM) which was formulated by incorporating a cell-wise strain smoothing operation into the standard compatible finite element method (FEM). These selective SFEM schemes were formulated based on three selective integration FEM schemes with similar properties found between the number of smoothing cells in the SFEM and the number of Gaussian integration points in the FEM. Both scheme 1 and scheme 2 are free of nearly incompressible locking, but scheme 2 is more general and gives better results than scheme 1. In addition, scheme 2 can be applied to anisotropic and nonlinear situations, while scheme 1 can only be applied to isotropic and linear situations. Scheme 3 is free of shear locking. This scheme can be applied to plate and shell problems. Results of the numerical study show that the selective SFEM schemes give more accurate results than the FEM schemes. 相似文献
166.
Climate-driven trends in contemporary ocean productivity 总被引:6,自引:0,他引:6
Behrenfeld MJ O'Malley RT Siegel DA McClain CR Sarmiento JL Feldman GC Milligan AJ Falkowski PG Letelier RM Boss ES 《Nature》2006,444(7120):752-755
Contributing roughly half of the biosphere's net primary production (NPP), photosynthesis by oceanic phytoplankton is a vital link in the cycling of carbon between living and inorganic stocks. Each day, more than a hundred million tons of carbon in the form of CO2 are fixed into organic material by these ubiquitous, microscopic plants of the upper ocean, and each day a similar amount of organic carbon is transferred into marine ecosystems by sinking and grazing. The distribution of phytoplankton biomass and NPP is defined by the availability of light and nutrients (nitrogen, phosphate, iron). These growth-limiting factors are in turn regulated by physical processes of ocean circulation, mixed-layer dynamics, upwelling, atmospheric dust deposition, and the solar cycle. Satellite measurements of ocean colour provide a means of quantifying ocean productivity on a global scale and linking its variability to environmental factors. Here we describe global ocean NPP changes detected from space over the past decade. The period is dominated by an initial increase in NPP of 1,930 teragrams of carbon a year (Tg C yr(-1)), followed by a prolonged decrease averaging 190 Tg C yr(-1). These trends are driven by changes occurring in the expansive stratified low-latitude oceans and are tightly coupled to coincident climate variability. This link between the physical environment and ocean biology functions through changes in upper-ocean temperature and stratification, which influence the availability of nutrients for phytoplankton growth. The observed reductions in ocean productivity during the recent post-1999 warming period provide insight on how future climate change can alter marine food webs. 相似文献
167.
168.
Direct detection of more than 50% of the Duchenne muscular dystrophy mutations by field inversion gels 总被引:5,自引:0,他引:5
Duchenne muscular dystrophy (DMD) is an X-linked disorder affecting about 1 in 3,500 males. It is allelic with the milder Becker muscular dystrophy. The biochemical basis for both diseases is unknown and no effective treatment is available. Long-range physical mapping has shown that the DMD gene, localized in Xp21, is extremely large, exceeding 2 million base pairs. Until now, carrier detection and prenatal diagnosis has involved the use of linked restriction fragment length polymorphism markers which detect muscular dystrophy-associated deletions in about 10% of the cases. Field inversion gel electrophoresis (FIGE) allows the detection of structural rearrangements in 21 out of 39 of the DMD patients studied (54%), of which 14 (65%) were not detected by conventional methods. Large deletions seem to make up a much higher fraction of the DMD mutations than so far indicated by other methods. A region prone to deletion was located in the distal half of the gene. FIGE analysis could provide a valuable extension of information for carrier detection and prenatal diagnosis. The technique should be generally applicable to the study of diseases involving structural chromosomal rearrangements. 相似文献
169.
基于分级遗传算法的结构损伤识别方法 总被引:6,自引:1,他引:6
提出了一种基于遗传算法的利用不完整振动数据识别结构损伤的新方法,该方法首先扩展不完整的振型并利用单元能量熵差比确定结构损伤的大致位置,然后采用二级搜索策略,借助遗传算法确定结构损伤的程度,数值计算结果表明,当可能的损伤区域较大时,本方法较直接搜索策略更能有效地确定结构损伤的程度。 相似文献
170.
Caloric restriction extends lifespan in numerous species. In the budding yeast Saccharomyces cerevisiae this effect requires Sir2 (ref. 1), a member of the sirtuin family of NAD+-dependent deacetylases. Sirtuin activating compounds (STACs) can promote the survival of human cells and extend the replicative lifespan of yeast. Here we show that resveratrol and other STACs activate sirtuins from Caenorhabditis elegans and Drosophila melanogaster, and extend the lifespan of these animals without reducing fecundity. Lifespan extension is dependent on functional Sir2, and is not observed when nutrients are restricted. Together these data indicate that STACs slow metazoan ageing by mechanisms that may be related to caloric restriction. 相似文献