Comparison study of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres

To compare two microspheres of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin loaded theophylline as pulmonary sustained drug delivery carriers, the characteristics and ciliotoxicity were studied. The drug loadings of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 21.09% and 21.42%, and the encapsulation efficiencies were 91.40% and 92.80%. The distributions of 50% (d _0.5) of chitosan/β-cyclodextrin and carboxymethyl chitosan/β-cyclodextrin microspheres were 4.89 and 5.83 μm, respectively. Both microspheres showed spherical shape with smooth or wrinkled surfaces. FT-IR of chitosan/β-cyclodextrin microspheres demonstrated that theophylline had formed hydrogen bonds with chitosan and β-cyclodextrin, while for the carboxymethyl chitosan/β-cyclodextrin microspheres theophylline had interaction with carboxymethyl chitosan. The moisture absorption showed that an equilibrium was reached within 24 h. The two microspheres possessed better adaptability. In vitro release of theophylline from chitosan/β-cyclodextrin microspheres was slower than that from carboxymethyl chitosan/β-cyclodextrin microspheres at pH 6.8. Biography: LI Ruobao(1968–), male, Associate professor, research direction: foundation research of respiratory system.     

Inferring requirement goals from model implemented in UML

UML is used widely in many software development processes. However, it does not make explicit requirement goals. Here is a method tending to establish the semantic relationship between requirements goals and UML models. Before the method is introduced, some relevant concepts are described.     

浅析电力变压器的事故处理

电力变压器是电力系统中很重要的设备,一旦发生事故,将造成很大的经济损失。分析各种电力变压器事故,找出原因,总结出处理事故的办法,把事故损失控制在最小范围内,尽量减少对系统的损害。     

TiC掺杂对MCMB烧结体组织和性能的影响

以Tween 80为分散剂,分别以丙烯酰胺和N,N'-亚甲基双丙烯酰胺为单体和交联剂,采用凝胶注模工艺制备中间相碳微球(mesocarbon microbead,MCMB)片状素坯,再经过1 600 ℃的烧结,制备MCMB素坯烧结体试样.试验研究了粒度大小对粉体分散性、MCMB碳材料催化石墨化效果、烧结后MCMB碳材料层板物理性能的影响,并分析了产生这些影响的原因.研究结果表明:50 nm的TiC在MCMB烧结体中的分散效果好于15 μm的TiC;随着Ti质量分数的增加,掺杂50 nm 的TiC层板性能优于掺杂15 μm的层板;50 nm的TiC比15 μm的TiC更适合做MCMB的掺杂物.     

汉代西北疆域的经济开发

西北边疆问题是研究汉代疆域史的一个重要问题,西北边疆的开发,促进了民族的融合和地区的发展.本文着力于从汉代对西北连续经济开发的主要工程、经济开发的意义及影响两个方面进行论述,从而为当今西部大开发提供一些历史借鉴.     

用正电子湮没寿命技术研究纯铜的形变缺陷

本文用正电子湮没寿命方法研究了形变纯铜缺陷产生的特点及其运动规律,讨论了位错密度和形变量之间的关系以及正电子寿命方法研究形变缺陷的适用范围。对试样所作的TEM观测得到与正电子寿命方法定性一致的结果。     

采面底板应力计算及应用

本文利用弹性理论推导了煤层底板任意点的应力计算公式。提出了通过计算岩石的强度指数来预计煤层底板的破坏深度。依据底板破坏深度与承压水的“原始导高”的关系预测煤层底板突水的可能性,并以现场实测数据验证了这种计算方法的可靠性。图5,表2,参考文献2。     

溴氨酸与芳胺缩合反应催化剂的研究

本文论述以硫酸铜代替氯化亚铜作为溴氨酸与芳胺缩合反应催化剂,收到了反应速度快,反应温度低,产品质量好,操作简便等效果。     

气液动六杆机构的分组综合法

本文采用分组综合和优化相结合的方法,讨论了以气液压缸作为主动件的平面六杆Stepheson型机构用作函数发生器的综合方法,全部求解过程采用了线性迭加技术,且设计点数不受待定参数的限制。     

协同萃取法从湿法磷酸中分离铁

发现了P538与P204的混合溶剂对文题有很强的协同效应。研究了该体系的萃取行为和性质,考察了混合溶剂的配比、磷酸浓度、两相接触时间、温度等因素对萃取行为的影响,从而确定了分离的最佳工艺条件:温度298K;平衡时间420s;溶剂配比为等摩尔的P538与P204及含40(v)%煤油;相比为1/2,2级逆流萃取;反萃取为:反萃余相浓度(?)=4.4kg/m~3,相比为1,温度298K,盐酸浓度为6kmol/m~3,理论级数为3级。初步研究了该协萃体系的萃取机理,萃合比为2。