The axon reflex sweating produced by potassium and sodium cyanides

Zusammenfassung Subkutane Einspritzung von Kalium- oder Natriumzyanid in die Zehenballen der Katze führt über einen Axonreflex zu merklichem Schwitzen. Dieser Effekt von Kaliumzyanid wird durch Procain und Atropin gehemmt, nicht aber durch Hexamethonium. Auch beim Menschen ruft intrakutan eingeführtes Natriumzyanid eine entsprechende Schweissabsonderung hervor.     

SMAD4-deficient intestinal tumors recruit CCR1+ myeloid cells that promote invasion

Inactivation of TGF-beta family signaling is implicated in colorectal tumor progression. Using cis-Apc(+/Delta716) Smad4(+/-) mutant mice (referred to as cis-Apc/Smad4), a model of invasive colorectal cancer in which TGF-beta family signaling is blocked, we show here that a new type of immature myeloid cell (iMC) is recruited from the bone marrow to the tumor invasion front. These CD34(+) iMCs express the matrix metalloproteinases MMP9 and MMP2 and the CC-chemokine receptor 1 (CCR1) and migrate toward the CCR1 ligand CCL9. In adenocarcinomas, expression of CCL9 is increased in the tumor epithelium. By deleting Ccr1 in the background of the cis-Apc/Smad4 mutant, we further show that lack of CCR1 prevents accumulation of CD34(+) iMCs at the invasion front and suppresses tumor invasion. These results indicate that loss of transforming growth factor-beta family signaling in tumor epithelium causes accumulation of iMCs that promote tumor invasion.     

Involvement of thiols in the induction of inward current induced by silver in frog skeletal muscle membrane

Exposure of voltage-clamped frog skeletal muscle fibres to silver caused a maintained inward current which could be carried by Ca²⁺, Mg²⁺ or Na⁺. Inorganic Ca²⁺ channel blockers and dithiothreitol (SH reducing agent) diminished this current, but a Na⁺ channel blocker did not. Thus, silver activates the Ca²⁺ channel by acting on SH groups in a Ca²⁺ channel protein.     

Demonstration of a quantum teleportation network for continuous variables

Quantum teleportation involves the transportation of an unknown quantum state from one location to another, without physical transfer of the information carrier. Although quantum teleportation is a naturally bipartite process, it can be extended to a multipartite protocol known as a quantum teleportation network. In such a network, entanglement is shared between three or more parties. For the case of three parties (a tripartite network), teleportation of a quantum state can occur between any pair, but only with the assistance of the third party. Multipartite quantum protocols are expected to form fundamental components for larger-scale quantum communication and computation. Here we report the experimental realization of a tripartite quantum teleportation network for quantum states of continuous variables (electromagnetic field modes). We demonstrate teleportation of a coherent state between three different pairs in the network, unambiguously demonstrating its tripartite character.     

Radiative forcing due to dust aerosol over east Asia-north Pacific region during spring, 2001

Atmosphericaerosolsinfluencetheradiationbudgetoftheatmosphere-terrestrialsystem,andthereforeinflu-encetheclimate.Dustaerosolisconsideredtobeacriticalfactortoclimateforcingamongotherkindsofaerosols,whichaccountsfor30percentofaerosolloadingandop-ticaldepth[1].Therearelargeuncertaintiesinthequantita-tiveassessmentsoftheradiativeeffectofdustatthepre-sentday,involvingvariousfactors:refractiveindices,par-ticlesizedistribution,atmosphericaerosolloading,parti-cleshape,etc.[2].Dustaerosolgenerallyorigi…     

Whole-genome sequencing of liver cancers identifies etiological influences on mutation patterns and recurrent mutations in chromatin regulators

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death worldwide. We sequenced and analyzed the whole genomes of 27 HCCs, 25 of which were associated with hepatitis B or C virus infections, including two sets of multicentric tumors. Although no common somatic mutations were identified in the multicentric tumor pairs, their whole-genome substitution patterns were similar, suggesting that these tumors developed from independent mutations, although their shared etiological backgrounds may have strongly influenced their somatic mutation patterns. Statistical and functional analyses yielded a list of recurrently mutated genes. Multiple chromatin regulators, including ARID1A, ARID1B, ARID2, MLL and MLL3, were mutated in ～50% of the tumors. Hepatitis B virus genome integration in the TERT locus was frequently observed in a high clonal proportion. Our whole-genome sequencing analysis of HCCs identified the influence of etiological background on somatic mutation patterns and subsequent carcinogenesis, as well as recurrent mutations in chromatin regulators in HCCs.     

The afterglow of GRB 050709 and the nature of the short-hard gamma-ray bursts

The final chapter in the long-standing mystery of the gamma-ray bursts (GRBs) centres on the origin of the short-hard class of bursts, which are suspected on theoretical grounds to result from the coalescence of neutron-star or black-hole binary systems. Numerous searches for the afterglows of short-hard bursts have been made, galvanized by the revolution in our understanding of long-duration GRBs that followed the discovery in 1997 of their broadband (X-ray, optical and radio) afterglow emission. Here we present the discovery of the X-ray afterglow of a short-hard burst, GRB 050709, whose accurate position allows us to associate it unambiguously with a star-forming galaxy at redshift z = 0.160, and whose optical lightcurve definitively excludes a supernova association. Together with results from three other recent short-hard bursts, this suggests that short-hard bursts release much less energy than the long-duration GRBs. Models requiring young stellar populations, such as magnetars and collapsars, are ruled out, while coalescing degenerate binaries remain the most promising progenitor candidates.