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71.
Normal 0 false false false MicrosoftInternetExplorer4 st1\:*{behavior:url(#ieooui) } /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin:0in; mso-para-margin-bottom:.0001pt; mso-pagination:widow-orphan; font-size:10.0pt; font-family:"Times New Roman"; mso-ansi-language:#0400; mso-fareast-language:#0400; mso-bidi-language:#0400;} Much research has been conducted on the mating systems of poeciliid fish in aquaria; however, there are fewer studies that examine mate sampling of these fish in the wild. In general, male poeciliids are characterized as being unselective in their mate choices and will attempt to copulate with seemingly all available females. Females are selective, copulate infrequently, and are often pursued by “ardent” males who may force copulations. To avoid male harassment, females in aquaria will often shelter from males among other females in shoals. Here, we examined the mate-sampling behaviors of male and female Pecos gambusia Gambusia nobilis by following individuals swimming in an outflow pool of Diamond Y Spring in southwestern Texas. In most cases, a male approached a solitary female, followed her briefly, and then left for no apparent reason. Approaching a number of females increased the likelihood that the male would follow one, and the longer a male followed a female, the more likely he was to copulate with her. As females were larger and faster than males, they could avoid males by swimming away from them. We found no evidence of the persistent males that harass seemingly unreceptive females as seen under aquarium conditions, nor did we see females join a shoal to stop pursuit by males. However, the activity of one male following a female did appear to attract other males who would compete to follow and attempt copulation. This competition might ensure that only superior males gain reproductive opportunities. Se han investigado extensamente los sistemas de apareamiento de pecílidos en acuario; no obstante, hay relativamente pocos estudios que examinan la elección de pareja de estos peces en su hábitat natural. Los pecílidos machos no suelen ser selectivos en su elección de pareja y parecen intentar copular con todas las hembras que estén a su alcance. Las hembras son selectivas, no copulan frecuentemente y a menudo las persiguen machos excitados que pueden copular con ellas forzadamente. Para evitar el acosamiento de los machos, en acuario las hembras a menudo se refugian de los machos entre otras hembras en bancos. Para este estudio, examinamos el comportamiento de elección de pareja de gambusias de pecos ( Gambusia nobilis ) machos y hembras al observar algunos individuos en un remanso del Diamond Y Spring en el suroeste de Texas. En la mayoría de los casos, el macho se acercaba a una hembra solitaria, la seguía brevemente y luego se alejaba sin motivo aparente. El acercarse a varias hembras aumentaba la probabilidad de que persiguiera a una de ellas, y cuanto más la seguía, más probable era que copulara con ella. Dado que las hembras son más grandes y más rápidas que los machos, podían eludirlos si no correspondían. No observamos machos persistentes que acosaran hembras aparentemente poco receptivas como se ha documentado en acuario, ni tampoco vimos hembras que se unieran a bancos para evitar la persecución de machos. Pero cuando un macho perseguía una hembra, parecía atraer otros, los cuales competían entre sí para seguirla e intentar copular con ella. Esta competencia podría garantizar que solo los machos superiores tengan oportunidades reproductivas. 相似文献
72.
Stephen Richard Alfred John Timothy Lambert Jr 《Systemic Practice and Action Research》2012,25(4):323-354
This is an exploratory case study of a management issue that confronts filmmakers: how do they select locations for their films? The outcome of those decisions can have vast and immediate effects upon the profitability of a film. This is a sometimes shadowy, but significant industry with a major economic impact. For systems theory advocates, students, and explorers, this study demonstrates that investigative, immersive action research techniques can be used to explore what are otherwise hidden, somewhat cloistered business organizations and industry structures that are ordinarily closed to outsiders. The soft-system of this industry that is rooted upon trust, loyalty, alliances, relationships, and other non-financial bonds influence its decisions, and its institutional performance. While this research is focused upon a fragment of the overall film industry worldwide, and is thus limited in the universality of the propositions that subsequently emerge, this study can serve as a springboard for research into other soft systems, from which new knowledge of managerial perspectives can emerge. 相似文献
73.
There is a powerful market-need for superfast disperse dyes in special use, e.g. for automotivefabrics. The photochemical fading reactions of dyes are often very complicated, and no singlphotodegradation pathway can be involved for all kinds of dyes. To enhance the photostability of the commonly used disperse dyes, a series of tests on the ef-fect of variable stabilizers on the photodegradation rate of nine representative disperse dyes werecarried out both in ethyl acetate solution and on cellulose acetate film. A moderate light sourceemitting above 300 nm was adopted in this study to simulate the photofading under practical appli-cations. The results show that, in solution, 2,2,6,6-tetramethyl-piperidine is the most effectivegeneral stabilizer for all the tested dyes, but on cellulose film, nickel diethyl-dithiocarbamateshows the greatest general protecting effect, and a synergistic effect is observed for special combina-tions of stabilizers. 相似文献
74.
75.
Mutations in genes encoding melanosomal proteins cause pigmentary glaucoma in DBA/2J mice. 总被引:11,自引:0,他引:11
Michael G Anderson Richard S Smith Norman L Hawes Adriana Zabaleta Bo Chang Janey L Wiggs Simon W M John 《Nature genetics》2002,30(1):81-85
Pigmentary glaucoma is a significant cause of human blindness. Abnormally liberated iris pigment and cell debris enter the ocular drainage structures, leading to increased intraocular pressure (IOP) and glaucoma. DBA/2J (D2) mice develop a form of pigmentary glaucoma involving iris pigment dispersion (IPD) and iris stromal atrophy (ISA). Using high-resolution mapping techniques, sequencing and functional genetic tests, we show that IPD and ISA result from mutations in related genes encoding melanosomal proteins. IPD is caused by a premature stop codon mutation in the Gpnmb (GpnmbR150X) gene, as proved by the occurrence of IPD only in D2 mice that are homozygous with respect to GpnmbR150X; otherwise, similar D2 mice that are not homozygous for GpnmbR150X do not develop IPD. ISA is caused by the recessive Tyrp1b mutant allele and rescued by the transgenic introduction of wildtype Tyrp1. We hypothesize that IPD and ISA alter melanosomes, allowing toxic intermediates of pigment production to leak from melanosomes, causing iris disease and subsequent pigmentary glaucoma. This is supported by the rescue of IPD and ISA in D2 eyes with substantially decreased pigment production. These data indicate that pigment production and mutant melanosomal protein genes may contribute to human pigmentary glaucoma. The fact that hypopigmentation profoundly alleviates the D2 disease indicates that therapeutic strategies designed to decrease pigment production may be beneficial in human pigmentary glaucoma. 相似文献
76.
An Erratum has been published for this article in Journal of Forecasting 23(6): 461 (2004) . This paper examines the problem of intrusion in computer systems that causes major breaches or allows unauthorized information manipulation. A new intrusion‐detection system using Bayesian multivariate regression is proposed to predict such unauthorized invasions before they occur and to take further action. We develop and use a multivariate dynamic linear model based on a unique approach leaving the unknown observational variance matrix distribution unspecified. The result is simultaneous forecasting free of the Wishart limitations that is proved faster and more reliable. Our proposed system uses software agent technology. The distributed software agent environment places an agent in each of the computer system workstations. The agent environment creates a user profile for each user. Every user has his or her profile monitored by the agent system and according to our statistical model prediction is possible. Implementation aspects are discussed using real data and an assessment of the model is provided. Copyright © 2002 John Wiley & Sons, Ltd. 相似文献
77.
Superoxide activates mitochondrial uncoupling proteins. 总被引:64,自引:0,他引:64
Karim S Echtay Damien Roussel Julie St-Pierre Mika B Jekabsons Susana Cadenas Jeff A Stuart James A Harper Stephen J Roebuck Alastair Morrison Susan Pickering John C Clapham Martin D Brand 《Nature》2002,415(6867):96-99
Uncoupling protein 1 (UCP1) diverts energy from ATP synthesis to thermogenesis in the mitochondria of brown adipose tissue by catalysing a regulated leak of protons across the inner membrane. The functions of its homologues, UCP2 and UCP3, in other tissues are debated. UCP2 and UCP3 are present at much lower abundance than UCP1, and the uncoupling with which they are associated is not significantly thermogenic. Mild uncoupling would, however, decrease the mitochondrial production of reactive oxygen species, which are important mediators of oxidative damage. Here we show that superoxide increases mitochondrial proton conductance through effects on UCP1, UCP2 and UCP3. Superoxide-induced uncoupling requires fatty acids and is inhibited by purine nucleotides. It correlates with the tissue expression of UCPs, appears in mitochondria from yeast expressing UCP1, and is absent in skeletal muscle mitochondria from UCP3 knockout mice. Our findings indicate that the interaction of superoxide with UCPs may be a mechanism for decreasing the concentrations of reactive oxygen species inside mitochondria. 相似文献
78.
Purification and cloning of amyloid precursor protein beta-secretase from human brain 总被引:40,自引:0,他引:40
Sinha S Anderson JP Barbour R Basi GS Caccavello R Davis D Doan M Dovey HF Frigon N Hong J Jacobson-Croak K Jewett N Keim P Knops J Lieberburg I Power M Tan H Tatsuno G Tung J Schenk D Seubert P Suomensaari SM Wang S Walker D Zhao J McConlogue L John V 《Nature》1999,402(6761):537-540
Proteolytic processing of the amyloid precursor protein (APP) generates amyloid beta (Abeta) peptide, which is thought to be causal for the pathology and subsequent cognitive decline in Alzheimer's disease. Cleavage by beta-secretase at the amino terminus of the Abeta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment. Cleavage of the C-terminal fragment by gamma-secretase(s) leads to the formation of Abeta. The pathogenic mutation K670M671-->N670L671 at the beta-secretase cleavage site in APP, which was discovered in a Swedish family with familial Alzheimer's disease, leads to increased beta-secretase cleavage of the mutant substrate. Here we describe a membrane-bound enzyme activity that cleaves full-length APP at the beta-secretase cleavage site, and find it to be the predominant beta-cleavage activity in human brain. We have purified this enzyme activity to homogeneity from human brain using a new substrate analogue inhibitor of the enzyme activity, and show that the purified enzyme has all the properties predicted for beta-secretase. Cloning and expression of the enzyme reveals that human brain beta-secretase is a new membrane-bound aspartic proteinase. 相似文献
79.
K. O. John 《Cellular and molecular life sciences : CMLS》1971,27(5):517-519
Résumé Le muscle pectoral duDraco dussumieri comprend des fibres de trois sortes: minces, intermédiaires et épaisses. Les fibres minces sont adaptées à un métabolisme glycolytique et les fibres épaisses au lipolytique. L'activité des fibres minces révèle la présence de phosphorylase et de synthétase glycogénique. 相似文献
80.
Archaeopteryx, the earliest known flying bird (avialan) from the Late Jurassic period, exhibits many shared primitive characters with more basal coelurosaurian dinosaurs (the clade including all theropods more bird-like than Allosaurus), such as teeth, a long bony tail and pinnate feathers. However, Archaeopteryx possessed asymmetrical flight feathers on its wings and tail, together with a wing feather arrangement shared with modern birds. This suggests some degree of powered flight capability but, until now, little was understood about the extent to which its brain and special senses were adapted for flight. We investigated this problem by computed tomography scanning and three-dimensional reconstruction of the braincase of the London specimen of Archaeopteryx. Here we show the reconstruction of the braincase from which we derived endocasts of the brain and inner ear. These suggest that Archaeopteryx closely resembled modern birds in the dominance of the sense of vision and in the possession of expanded auditory and spatial sensory perception in the ear. We conclude that Archaeopteryx had acquired the derived neurological and structural adaptations necessary for flight. An enlarged forebrain suggests that it had also developed enhanced somatosensory integration with these special senses demanded by a lifestyle involving flying ability. 相似文献