机构系统概念设计中功能到行为的映射方法

基于功能-行为-结构映射的机构系统概念设计模型,通过与功能相关联物理行为的综合,实现功能到结构的转换;通过分析执行动作形式,定义了有效工作时段的动作形式;在确定工作原理的条件下,建立了构造功能与有效工作时段动作映射矩阵的方法.根据专家经验,对能实现一个功能的所有有效工作时段动作进行评价,建立了从整个工艺动作过程的动作方案,集中寻求最优化有效工作时段动作方案的评价规则、数学模型和求解方法,并给出实例.     

Indole-3-carbinol enhances ultraviolet B-induced apoptosis by sensitizing human melanoma cells

Indole-3-carbinol (I3C) has been found to act against several types of cancer, while ultraviolet B (UVB) is known to induce the apoptosis of human melanoma cells. Here, we investigated whether I3C can sensitize G361 human melanoma cells to UVB-induced apoptosis. We examined the effects of combined I3C and UVB (I3C/UVB) at various dosages. I3C (200 μM)/UVB (50 mJ/cm²) synergistically reduced melanoma cell viability, whereas I3C (200 μM) or UVB (50 mJ/cm²), separately, had little effect on cell viability. DNA fragmentation assays indicated that I3C/UVB induced apoptosis. Further results show that I3C/UVB activates caspase-8, −3, and Bid and causes the cleavage of poly(ADP-ribose) polymerase. Moreover, I3C decreased the expression of the anti-apoptotic protein, Bcl-2, whereas UVB increased the translocation of Bax to mitochondria. Thus, an increased Bax/Bcl-2 ratio by I3C/UVB may result in melanoma apoptosis. In conclusion, our study demonstrated that I3C sensitizes human melanoma cells by down-regulating Bcl-2. Received 5 July 2006; received after revision 25 August 2006; accepted 11 September 2006     

A model for knowledge transfer in a multi-agent organization based on lattice kinetic model

A study on knowledge transfer in a mutli-agent organization is performed by applying the basic principle in physics such as the kinetic theory.Based on the theoretical analysis of the knowledge accumulation process and knowledge transfer attributes,a special type of knowledge field(KF)is introduced and the knowledge diffusion equation(KDE)is developed.The evolution of knowledge potential is modeled by lattice kinetic equation and verified by numerical experiments.The new equation-based modeling developed in this paper is meaningful to simulate and predict the knowledge transfer process in firms.The development of the lattice kinetic model(LKM)for knowledge transfer can contribute to the knowledge management theory,and the managers can also simulate the knowledge accumulation process by using the LKM.     

A novel explosive process is required for the gamma-ray burst GRB 060614

Over the past decade, our physical understanding of gamma-ray bursts (GRBs) has progressed rapidly, thanks to the discovery and observation of their long-lived afterglow emission. Long-duration (> 2 s) GRBs are associated with the explosive deaths of massive stars ('collapsars', ref. 1), which produce accompanying supernovae; the short-duration (< or = 2 s) GRBs have a different origin, which has been argued to be the merger of two compact objects. Here we report optical observations of GRB 060614 (duration approximately 100 s, ref. 10) that rule out the presence of an associated supernova. This would seem to require a new explosive process: either a massive collapsar that powers a GRB without any associated supernova, or a new type of 'engine', as long-lived as the collapsar but without a massive star. We also show that the properties of the host galaxy (redshift z = 0.125) distinguish it from other long-duration GRB hosts and suggest that an entirely new type of GRB progenitor may be required.     

Nuclear isomers in superheavy elements as stepping stones towards the island of stability

A long-standing prediction of nuclear models is the emergence of a region of long-lived, or even stable, superheavy elements beyond the actinides. These nuclei owe their enhanced stability to closed shells in the structure of both protons and neutrons. However, theoretical approaches to date do not yield consistent predictions of the precise limits of the 'island of stability'; experimental studies are therefore crucial. The bulk of experimental effort so far has been focused on the direct creation of superheavy elements in heavy ion fusion reactions, leading to the production of elements up to proton number Z = 118 (refs 4, 5). Recently, it has become possible to make detailed spectroscopic studies of nuclei beyond fermium (Z = 100), with the aim of understanding the underlying single-particle structure of superheavy elements. Here we report such a study of the nobelium isotope 254No, with 102 protons and 152 neutrons--the heaviest nucleus studied in this manner to date. We find three excited structures, two of which are isomeric (metastable). One of these structures is firmly assigned to a two-proton excitation. These states are highly significant as their location is sensitive to single-particle levels above the gap in shell energies predicted at Z = 114, and thus provide a microscopic benchmark for nuclear models of the superheavy elements.     

基于麦克风阵列多声源定位的新方法

针对传统方法不能准确地测量远场多声源位置的问题,提出了在近场和远场都能用的多声源定位新方法.该方法采用两个L型麦克风阵列,在每个阵列通过多声源的频率及到达角的联合估计求得信号源的夹角,基于每个信号源的夹角对估计多声源的位置.通过仿真实验验证了该方法在近场、远场都能准确地测量多声源位置,通过调节两个L型麦克风阵列之间的距离能得到误差在5%以下的声源定位精度.