A new peripheral monoamine oxidase inhibitor: 2,9-dimethyl-β-carbolinium iodide

Resumen Yoduro de 2, 9-dimetilo-carbolinio (DMCI) y no sus metabolitos inhibió la enzyma monoamino oxidasa y elevó¹⁴C-serotonia en el corazón e higado, pero no en el cerebro de ratas.

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This work is taken in part from the M. S. thesis presented byP. M. Gardner to the University of Texas Graduate School of Biomedical Sciences at Houston, 1971.     

Difference in direct charge-parity violation between charged and neutral B meson decays

Equal amounts of matter and antimatter are predicted to have been produced in the Big Bang, but our observable Universe is clearly matter-dominated. One of the prerequisites for understanding this elimination of antimatter is the nonconservation of charge-parity (CP) symmetry. So far, two types of CP violation have been observed in the neutral K meson (K(0)) and B meson (B(0)) systems: CP violation involving the mixing between K(0) and its antiparticle (and likewise for B(0) and ), and direct CP violation in the decay of each meson. The observed effects for both types of CP violation are substantially larger for the B(0) meson system. However, they are still consistent with the standard model of particle physics, which has a unique source of CP violation that is known to be too small to account for the matter-dominated Universe. Here we report that the direct CP violation in charged B(+/-)-->K(+/-)pi(0) decay is different from that in the neutral B(0) counterpart. The direct CP-violating decay rate asymmetry, (that is, the difference between the number of observed B(-)-->K(-)pi(0) event versus B(+)-->K(+) pi(0) events, normalized to the sum of these events) is measured to be about +7%, with an uncertainty that is reduced by a factor of 1.7 from a previous measurement. However, the asymmetry for versus B(0)-->K(+)pi(-) is at the -10% level. Although it is susceptible to strong interaction effects that need further clarification, this large deviation in direct CP violation between charged and neutral B meson decays could be an indication of new sources of CP violation-which would help to explain the dominance of matter in the Universe.     

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production

Systems for protein degradation are essential for tight control of the inflammatory immune response. Autophagy, a bulk degradation system that delivers cytoplasmic constituents into autolysosomes, controls degradation of long-lived proteins, insoluble protein aggregates and invading microbes, and is suggested to be involved in the regulation of inflammation. However, the mechanism underlying the regulation of inflammatory response by autophagy is poorly understood. Here we show that Atg16L1 (autophagy-related 16-like 1), which is implicated in Crohn's disease, regulates endotoxin-induced inflammasome activation in mice. Atg16L1-deficiency disrupts the recruitment of the Atg12-Atg5 conjugate to the isolation membrane, resulting in a loss of microtubule-associated protein 1 light chain 3 (LC3) conjugation to phosphatidylethanolamine. Consequently, both autophagosome formation and degradation of long-lived proteins are severely impaired in Atg16L1-deficient cells. Following stimulation with lipopolysaccharide, a ligand for Toll-like receptor 4 (refs 8, 9), Atg16L1-deficient macrophages produce high amounts of the inflammatory cytokines IL-1beta and IL-18. In lipopolysaccharide-stimulated macrophages, Atg16L1-deficiency causes Toll/IL-1 receptor domain-containing adaptor inducing IFN-beta (TRIF)-dependent activation of caspase-1, leading to increased production of IL-1beta. Mice lacking Atg16L1 in haematopoietic cells are highly susceptible to dextran sulphate sodium-induced acute colitis, which is alleviated by injection of anti-IL-1beta and IL-18 antibodies, indicating the importance of Atg16L1 in the suppression of intestinal inflammation. These results demonstrate that Atg16L1 is an essential component of the autophagic machinery responsible for control of the endotoxin-induced inflammatory immune response.     

A contribution on the effect of noradrenaline on heat production in mice

Zusammenfassung Bei ausgewachsenen Mäusen wurde nach i.p. Noradrenalininjektion die Steigerung der O₂-Aufnahme über den Grundumsatz in der Thermoneutralzone verfolgt. Nach einer Dosis von 1,6 mg/kg wurde ein bedeutender Unterschied (p < 0,05) der O₂-Aufnahmesteigerung zwischen der Gruppe normaler (155%) und normaler, auf 17°C adaptierter Mäuse (165%) und der Gruppe haarloser Mäuse (195%) festgestellt.     

Influence of operational parameters on the photocatalytic performance of DE-NOx process Via MIL-101(Fe)

Metal organic framework(MOF)has been paid great attention as a potential candidate for various applications in the field of energy and environment,particularly in air purification.Among various MOFs,MIL-101(Fe) represents an interesting material possessing many advantages,including the ease of fabrication,high porosity,high specific surface area with open metal sites,making it a promising material in the field of harmful gas treatment.Taking these advantages,MIL-101(Fe) was synthesized by facile microwave-solvothermal method and applied as a photocatalyst for the degradation of NO_x.The de-NO_x efficiency of the synthesized powder was evaluated with respect to various operating parameters including substrates,sample doses,light spectrum and light intensity,initial NO concentration,and relative humidity.The results have shown that the efficiency of NO_x photocatalytic degradation reaches to 77%under solar irradiation via 0.1 g of MIL-101(Fe) with optimum condition of reaction,(alumina substrate,350 ppb of initial NO concentration,40–50%of relative humidity).Then this work provides the optimum condition for the efficient photocatalytic degradation of NO_x.     

Blue TiO2 polymorph: An efficient material for dye-sensitized solar cells fabricated using a low-temperature sintering process

Recently,surface-disordered or non-stoichiometric TiO_2,such as blue TiO_2(B-TiO_2),has received much attention owing to its unique properties,such as structural disorder near the surface and the existence of Ti~(3+)ions and oxygen vacancies.Therefore,surface-disordered TiO_2has been applied for microwave absorption,photocatalysis,in photoelectrochemical sensors and rechargeable lithium-ion batteries.In this work B-TiO_2,a polymorph consisting of nanoparticles,nanotubes and nanosheets,was successfully synthesized and employed as a semiconductor layer in dye-sensitized solar cells(DSSCs)fabricated using a low-temperature heat treatment process(120°C).Based on the analyses of the experimental results regarding the structure and those from the characterization of B-TiO_2,and its application to DSSCs,it has been found that the B-TiO_2 material has an effect on electron-hole pair separation.The conversion efficiency of the B-TiO_2 DSSC(BTiO_2-DSSC)was 6.18%,whereas that of the TiO_2-P25 DSSC(P25-DSSC)was 3.61%,and that of the TiO_2 polymorph DSSC(PTiO_2-DSSC)which is the precursor of B-TiO_2 was 4.51%.     

中韩戏剧接受日本《不如归》的比较研究

德富芦花的<不如归>不但是日本近代文学史上影响深远的长篇小说,而且对于韩中两国现代性文学的形成,起了很重要的作用.两国对<不如归>的接受都是从小说的翻译改编开始的,但在剧奉的具体接受途径上却有明显差异.韩中两国<不如归>的演出,标志着现代性戏剧脱离初期阶段而演变为以家庭悲剧为主的大众戏剧艺术.中国认为<不如归>中的悲剧所在是"情",而韩国则扩展为"幽恨",从中获得比原作更为强烈的戏剧性艺术感受.     

An overview of marine & utility system for offshore platform

Main marine & utility (M & U) systems are essential to the routine operation of offshore units,and are extremely important as they are the system that will ensure the basic safety of offshore platforms. This paper gave a general explanation and guideline of the marine & utility systems in offshore projects including their interface with topside,M & U engineering,equipment sizing operation and control.     

消费者TV家庭冲动购物的激励因素

以TV家庭购物和冲动购买为研究基础,分析冲动购物的激励因素,通过检验设定的问题来确定其影响力.分析有一次以上TV家庭购物的303名消费者的调查资料,得出:(1)分析产品激励因素对专卖商品和流行商品的影响,结果表明,激励冲动购物只对流行商品有影响.(2)在促销激励因素中,提供赠品的激励和扩大信用卡打折期限的激励对冲动购物都有一定影响,后者影响更大.(3)价格激励因素中,大幅度降低商品价值的激励比合理的价值激励对冲动购物影响更大.(4)情境激励因素特性表明,引导销售激励比限量销售激励影响更大.(5)消费者TV家庭购物视听关联特性表明,看TV时间长比与有伴看电视对消费者冲动购物影响更大.